methyl 4-amino-3,6-dichloro-5-fluoropicolinate | 496850-09-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: methyl 4-amino-3,6-dichloro-5-fluoropicolinate
• 英文别名: methyl 4-amino-3,6-dichloro-5-fluoropyridine-2-carboxylate
• CAS: 496850-09-0
• 化学式: C₇H₅Cl₂FN₂O₂
• 分子量: 239.033
• InChiKey: KIKNEFFJHGIUKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  65.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 4-amino-3,6-dichloro-5-fluoropicolinate 在 bis-triphenylphosphine-palladium(II) chloride 、 potassium fluoride 、 水 、 sodium hydroxide 作用下， 以 甲醇 、 水 、 乙腈 为溶剂， 反应 16.33h， 生成 4-amino-3-chloro-6-(4-chlorophenyl)-5-fluoropicolinic acid
  参考文献：
  名称：

  The discovery of Arylex™ active and Rinskor™ active: Two novel auxin herbicides

  摘要：

  Multiple classes of commercially important auxin herbicides have been discovered since the 1940s including the aryloxyacetates (2,4-D, MCPA, dichlorprop, mecoprop, triclopyr, and fluroxypyr), the benzoates (dicamba), the quinoline-2-carboxylates (quinclorac and quinmerac), the pyrimidine-4-carboxylates (aminocyclopyrachlor), and the pyridine-2-carboxylates (picloram, clopyralid, and aminopyralid). In the last 10 years, two novel pyridine-2-carboxylate (or picolinate) herbicides were discovered at Dow AgroSciences. This paper will describe the structure activity relationship study that led to the discovery of the 6-aryl-picolinate herbicides Arylex (TM) active (2005) and Rinskor (TM) active (2010). While Arylex was developed primarily for use in cereal crops and Rinskor is still in development primarily for use in rice crops, both herbicides will also be utilized in additional crops. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.08.011
• 作为产物：
  描述：

  4-amino-3-chloro-5,6-difluoropicolinonitrile 在 磺酰氯 、 硫酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 69.75h， 生成 methyl 4-amino-3,6-dichloro-5-fluoropicolinate
  参考文献：
  名称：

  PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED) PICOLINATES

  摘要：

  4-氨基-3-氯-5-氟-6-(取代基)吡啶酸盐可以通过一系列步骤方便地从3,4,5,6-四氯吡啶腈制备，其中包括氟交换，氨化，与肼反应，卤代反应，水解和酯化，以及过渡金属辅助偶联。

  公开号：

  US20120190858A1

文献信息

• [EN] PYRIDINE AND PYRIMIDINE CARBOXYLATE HERBICIDES AND METHODS OF USE THEREOF<br/>[FR] HERBICIDES CARBOXYLATES DE PYRIDINE ET DE PYRIMIDINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2019084353A1

  公开（公告）日：2019-05-02

  Provided herein are pyridine and pyrimidine carboxylates and their derivatives, and compositions and methods of use thereof as herbicides.

  本文提供吡啶和嘧啶羧酸盐及其衍生物，以及它们作为除草剂的组合物和使用方法。
• ARYLALKYL ESTERS OF 4-AMINO-6-(SUBSTITUTED PHENYL)-PICOLINATES AND 6-AMINO-2-(SUBSTITUTED PHENYL)-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS
  申请人：Yerkes Carla N.

  公开号：US20120190551A1

  公开（公告）日：2012-07-26

  Arylalkyl esters of 4-aminopicolinic acids and 6-amino-4-pyrimidinecarboxylates are herbicides for control of weeds especially those species common to rice and wheat cropping systems and in pasture management programs.

  芳基烷基对氨基吡啶甲酸酯和6-氨基-4-嘧啶羧酸酯是除草剂，用于控制杂草，特别是那些在稻田和小麦种植系统以及牧草管理计划中常见的物种。
• PYRIDINE-BASED COMPOUND INCLUDING ISOXAZOLINE RING AND USE THEREOF AS HERBICIDE
  申请人：MOGHU RESEARCH CENTER LTD.

  公开号：US20190159450A1

  公开（公告）日：2019-05-30

  A pyridine-based compound containing an isoxazoline ring represented by Formula 1 or an agrochemically acceptable salt thereof can be used as a herbicide. A method of preparing the pyridine-based compound containing an isoxazoline ring represented by Formula 1 includes reacting a compound represented by Formula 2 with a compound represented by Formula 3.

  一种含有异噁唑啉环的吡啶基化合物，其化学式如下（Formula 1），或其农药可接受的盐，可用作除草剂。制备这种含有异噁唑啉环的吡啶基化合物的方法包括将化合物（Formula 2）与化合物（Formula 3）进行反应。
• 4-AMINO-6-(HALO-SUBSTITUTED-ALKYL)-PICOLINATES AND THEIR USE AS HERBICIDES
  申请人：Dow AgroSciences LLC

  公开号：US20150164074A1

  公开（公告）日：2015-06-18

  Provided herein are 4-amino-6-(halo-substituted-alkyl)-picolinic acids and their derivatives, compositions comprising the acids and their derivatives, and methods of use thereof as herbicides.

  本文提供了4-氨基-6-(卤代烷基取代)-吡啶甲酸及其衍生物，包括这些酸及其衍生物的组合物，以及将其用作除草剂的方法。
• 6-Aryl-4-aminopicolinates and their use as herbicides
  申请人：——

  公开号：US20030114311A1

  公开（公告）日：2003-06-19

  4-Aminopicolinic acids having aryl or heteroaryl substituents in the 6-position and their amine and acid derivatives are potent herbicides demonstrating a broad spectrum of weed control.

  在6位上具有芳基或杂环芳基取代基的4-氨基吡啶甲酸及其胺和酸衍生物是有效的除草剂，展示了广泛的杂草控制谱。