triethylene glycol monobutyl ether tosylate | 117783-11-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: triethylene glycol monobutyl ether tosylate
• 英文别名: 2-[2-(2-Butoxyethoxy)ethoxy]ethyl 4-methylbenzene-1-sulfonate；2-[2-(2-butoxyethoxy)ethoxy]ethyl 4-methylbenzenesulfonate
• CAS: 117783-11-6
• 化学式: C₁₇H₂₈O₆S
• 分子量: 360.472
• InChiKey: SCOBKWYTBDRAOQ-UHFFFAOYSA-N

物化性质

• 沸点：
  468.9±35.0 °C(Predicted)
• 密度：
  1.121±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  79.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  triethylene glycol monobutyl ether tosylate 在 hydrazine hydrate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.0h， 生成 2-[2-(2-丁氧基乙氧基)乙氧基]乙胺
  参考文献：
  名称：

  A Synthesis of Acetamidines

  摘要：

  The condensation of primary amine with N,N-dimethylacetamide dimethyl acetal yields a mixture of acetamidine and imidate ester. The product distribution in this reaction depends on the temperature, solvent, and structure of the primary amine. It is possible to suppress the formation of imidate ester by performing the reaction in the presence of excess dimethyl amine, yielding acetamidine as the exclusive product. For acetamidines that cannot be purified either by crystallization or distillation, this new method is necessary for the generation of pure acetamidines in good yields.

  DOI：

  10.1021/jo102358d
• 作为产物：
  描述：

  三乙二醇单丁醚 、 对甲苯磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以68 %的产率得到triethylene glycol monobutyl ether tosylate
  参考文献：
  名称：

  Internal Dynamics and Modular Peripheral Binding in Stimuli‐Responsive 3 : 2 Host:Guest Complexes

  摘要：

  摘要现在，1 ：1 的主客体复合物的化学性质已经得到了很好的证实，但令人惊讶的是，较高化学计量（寡聚）的复合物，尤其是那些含有过量宿主的复合物，在很大程度上仍未得到探索。然而，蛋白质往往会寡聚，从而为细胞机械提供新的功能。在这里，我们展示了葫芦[n]脲（CB[n]）大环与对称线性二维原结合形成不寻常的 3 : 2 主客复合物，表现出显著的动态特性、宿主自排序和外部环形转移。这些结果凸显了基于葫芦[8]脲（CB[8]）的 3 : 2 主客复合物在水中的结构可调性及其对多种刺激（化学物质、pH 值、氧化还原）的响应性。

  DOI：

  10.1002/anie.202315985

文献信息

• Design and Synthesis of Polymeric Chiral Bicyclo[3.3.0] Diene as Reusable Ligand for Rhodium-Catalyzed Asymmetric 1,4-Addition
  作者：Hongyu Yang、Minghua Xu

  DOI：10.1002/cjoc.201201079

  日期：2013.1

  A series of A‐B type sterically regular bicyclio[3.3.0] diene‐based polymers were designed and synthesized as immobilized chiral diene ligands for asymmetric catalysis. With polymeric diene 6b, good to excellent enantioselectivities can be achieved in Rh‐catalyzed asymmetric 1,4‐addition of arylboronic acids to α,β‐unsaturated ketones.

  设计并合成了一系列基于A‐B型空间正则双环[3.3.0]二烯的聚合物，作为固定的手性二烯配体进行不对称催化。使用聚合二烯6b，可以在Rh催化的芳基硼酸的不对称1,4-加成反应中获得出色的对映选择性，对α，β-不饱和酮。
• IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE
  申请人：Arvinas, Inc.

  公开号：US20150291562A1

  公开（公告）日：2015-10-15

  The description relates to imide-based compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

  该描述涉及基于亚醰基的化合物，包括包含它们的双官能团化合物，这些化合物在靶向泛素化调节中发挥作用，特别是根据本发明的双官能团化合物抑制各种多肽和其他蛋白质的降解和/或抑制。具体来说，该描述提供了一种化合物，其中一端含有与小脑素E3泛素连接酶结合的配体，另一端含有结合目标蛋白的基团，使目标蛋白靠近泛素连接酶，以实现该蛋白的降解（和抑制）。可以合成表现出与几乎任何类型的靶向多肽的降解/抑制一致的广泛药理活性的化合物。
• Naphthalene compound, and liquid crystal composition and liquid crystal element using the same
  申请人：MITSUI TOATSU CHEMICALS, INC.

  公开号：EP0757032A2

  公开（公告）日：1997-02-05

  Provided is a naphthalene compound represented by the following Formula (1) : wherein R1 and R2 each represent a linear or branched alkyl group having 1 to 20 carbon atoms, an alkoxyalkyl group having 2 to 20 carbon atoms or an alkenyl group having 2 to 20 carbon atoms which may be substituted with halogen atoms and have no asymmetric carbon atoms; A represents any of the groups represented by the following formulas: (wherein X1, X2, X3 and X4 each represent a hydrogen atom or a halogen atom); and z represents 0 or 1. The addition of this naphthalene compound to a liquid crystal composition makes it possible to improve various characteristics such as the high speed response property of the liquid crystal composition and the temperature dependency of the response time. The above naphthalene compound is useful as a liquid crystal material for liquid crystal compositions, particularly ferroelectric liquid crystal compositions.

  本发明提供了一种由下式（1）表示的萘化合物： 其中 R1 和 R2 分别代表具有 1 至 20 个碳原子的直链或支链烷基、具有 2 至 20 个碳原子的烷氧基烷基或具有 2 至 20 个碳原子的烯基，它们可被卤素原子取代且没有不对称碳原子；A 代表下列式子所代表的任何基团： (其中 X1、X2、X3 和 X4 各代表一个氢原子或一个卤素原子）；以及 z 代表 0 或 1。在液晶组合物中加入这种萘化合物可以改善各种特性，如液晶组合物的高速响应特性和响应时间的温度依赖性。上述萘化合物可用作液晶组合物，特别是铁电液晶组合物的液晶材料。
• Naphtahlene compound, and liquid crystal composition and liquid crystal element using the same
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1120400A1

  公开（公告）日：2001-08-01

  Provided is a naphthalene compound represented by the following Formula (1): wherein R1 and R2 each represent a linear or branched alkyl group having 1 to 20 carbon atoms, an alkoxyalkyl group having 2 to 20 carbon atoms or an alkenyl group having 2 to 20 carbon atoms which may be substituted with halogen atoms and have no asymmetric carbon atoms; provided that at least one of R1 and R2 is an alkoxyalkyl group represented by Formula (III):         -CdH2dO(CeH2eO)fCgH2g+1     (III) (wherein d represents a natural number of 1 to 10; e represents a natural number of 1 to 10; f represents a natural number of 0 to 5; and g represents a natural number of 1 to 12, provided that d + e x f + g ≤ 20); A represents any of the groups represented by the following formulas: (wherein X1, X2, X3 and X4 each represent a hydrogen atom or a halogen atom); and z represents 0 or 1. The addition of this naphthalene compound to a liquid crystal composition makes it possible to improve various characteristics such as the high speed response property of the liquid crystal composition and the temperature dependency of the response time. The above naphthalene compound is useful as a liquid crystal material for liquid crystal compositions, particularly ferroelectric liquid crystal compositions.

  本发明提供了由下式（1）表示的萘化合物： 其中 R1 和 R2 分别代表具有 1 至 20 个碳原子的直链或支链烷基、具有 2 至 20 个碳原子的烷氧基烷基或具有 2 至 20 个碳原子的烯基，它们可被卤素原子取代且不具有不对称碳原子；条件是 R1 和 R2 中至少有一个是式 (III) 所代表的烷氧基烷基： -CdH2dO(CeH2eO)fCgH2g+1 (III) (其中 d 代表 1 至 10 的自然数；e 代表 1 至 10 的自然数；f 代表 0 至 5 的自然数；g 代表 1 至 12 的自然数，条件是 d + e x f + g ≤ 20)；A 代表下式所代表的任何基团： (其中 X1、X2、X3 和 X4 各代表一个氢原子或一个卤素原子）；以及 z 代表 0 或 1。在液晶组合物中加入这种萘化合物可以改善各种特性，如液晶组合物的高速响应特性和响应时间的温度依赖性。上述萘化合物可用作液晶组合物，特别是铁电液晶组合物的液晶材料。
• Amino silane-based compound, method of preparing the same, and modified conjugated diene-based polymer including the compound
  申请人：LG Chem, Ltd.

  公开号：US10800862B2

  公开（公告）日：2020-10-13

  An amino silane-based compound, methods of preparing the same, and a modified conjugated diene-based polymer including an amino silane-based functional group are disclosed herein. In an embodiment, the amino silane-based compound is represented by Formula 1: wherein, in Formula 1, R1 and R2 are each independently a hydrocarbon group having 1 to 30 carbon atoms, or a glycol unit represented by R3 is a divalent hydrocarbon group having 1 to 30 carbon atoms, R4, R5, R6, and R7 are each independently a monovalent hydrocarbon group having 1 to 30 carbon atoms, R8 is a divalent hydrocarbon group having 1 to 10 carbon atoms, j and k are each independently 0 or 1, n is an integer selected from 1 to 10, wherein at least one of R1 or R2 is the glycol unit.

  本文公开了一种氨基硅烷基化合物、其制备方法以及包括氨基硅烷基官能团的改性共轭二烯基聚合物。在一个实施方案中，氨基硅烷基化合物由式 1 表示： 其中，在式 1 中 R1 和 R2 分别独立地为具有 1 至 30 个碳原子的烃基，或由以下各项表示的乙二醇单元 R3 是具有 1 至 30 个碳原子的二价烃基，R4、R5、R6 和 R7 各自独立地是具有 1 至 30 个碳原子的一价烃基，R8 是具有 1 至 10 个碳原子的二价烃基，j 和 k 各自独立地是 0 或 1，n 是选自 1 至 10 的整数，其中 R1 或 R2 中至少有一个是乙二醇单元。