4-methoxyethoxymethoxytoluene | 101327-95-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-methoxyethoxymethoxytoluene
• 英文别名: 1-((2-methoxyethoxy)methoxy)-4-methylbenzene；1-(2-Methoxyethoxymethoxy)-4-methylbenzene
• CAS: 101327-95-1
• 化学式: C₁₁H₁₆O₃
• 分子量: 196.246
• InChiKey: PBBXLWNSSQFKOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methoxyethoxymethoxytoluene 在 氨 、 lithium 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 2.0h， 以91%的产率得到1-methoxyethoxymethoxy-4-methyl-1,4-cyclohexadiene
  参考文献：
  名称：

  Bhushan, Vidya; Rajopadhye, M. M.; Chandrasekaran, S, Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985, vol. 24, p. 424 - 425

  摘要：

  DOI：
• 作为产物：
  描述：

  对甲酚 、 2-甲氧基乙氧基甲基氯 在 sodium hydride 作用下， 生成 4-methoxyethoxymethoxytoluene
  参考文献：
  名称：

  Bhushan, Vidya; Rajopadhye, M. M.; Chandrasekaran, S, Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985, vol. 24, p. 424 - 425

  摘要：

  DOI：

文献信息

• Silver‐Promoted Oxidative Benzylic C−H Trifluoromethoxylation
  作者：Haodong Yang、Feng Wang、Xiaohuan Jiang、Yu Zhou、Xiufang Xu、Pingping Tang

  DOI：10.1002/anie.201807144

  日期：2018.10

  silver‐promoted oxidative benzylic C−H trifluoromethoxylation has been reported for the first time. With trifluoromethyl arylsulfonate as the trifluoromethoxylation reagent, various arenes, having diverse functional groups, undergo trifluoromethoxylation of their benzylic C−H bonds to form trifluoromethyl ethers under mild reaction conditions. In addition, the trifluoromethoxylation and the fluorination of methyl

  首次报道了银促进的氧化苄基CH三氟甲氧基化反应。用三氟甲基芳基磺酸盐作为三氟甲氧基化试剂，具有不同官能团的各种芳烃在温和的反应条件下对其苄基CH键进行三氟甲氧基化，形成三氟甲基醚。此外，已经实现了一步法制备富电子芳烃的三氟甲氧基化和甲基氟化，以制备α-氟苄基三氟甲基醚。
• [1,2,4] Triazolo [1,5, a] pyrimidin-2-ylurea derivative and use thereof
  申请人：Masuda Akira

  公开号：US20070010515A1

  公开（公告）日：2007-01-11

  Novel [1,2,4]triazolo[1,5-a]pyrimidine derivative of the general formula (1): (1) its prodrug or a pharmaceutically acceptable salt thereof, which exhibits an antigen presentation inhibiting activity and is useful as a preventive and/or therapeutic agent for immunological rejection and/or graft versus host reaction in organ/bone marrow transplant, autoimmune disease, allergic disease and/or inflammatory disease and also useful as an anticancer drug or as an immunological tolerance inducer for transplanted organ/transplanted bone marrow.

  这是一种通式为(1)的[1,2,4]三唑并[1,5-a]嘧啶衍生物的小说，其中(1)是其前药或其药学上可接受的盐，具有抗原呈递抑制活性，可用作预防和/或治疗器官/骨髓移植、自身免疫性疾病、过敏性疾病和/或炎症性疾病的免疫排斥和/或移植物抗宿主反应的预防和/或治疗剂，同时也可用作抗癌药物或用于移植器官/移植骨髓的免疫耐受诱导剂。
• BHUSHAN, VIDYA;RAJOPADHYE, M. M.;CHANDRASEKARAN, S., INDIAN J. CHEM., 1985, 24, N 4, 424-425
  作者：BHUSHAN, VIDYA、RAJOPADHYE, M. M.、CHANDRASEKARAN, S.

  DOI：——

  日期：——
• US7598244B2
  申请人：——

  公开号：US7598244B2

  公开（公告）日：2009-10-06
• [EN] HETEROARYL COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROARYLÉS ET LEURS UTILISATIONS
  申请人：CELGENE AVILOMICS RES INC

  公开号：WO2014100748A1

  公开（公告）日：2014-06-26

  The present invention provides certain compounds, and compositions thereof, useful as protein kinase inhibitors. In particular, the present invention provides certain 2,4-disubstituted pyrimidine compounds which inhibit activity of one or more protein kinases, including Bruton's tyrosine kinase ("BTK"), a member of TEC-kinases (e.g., TEC, BTK, IL2-inducible T -cell kinase (ITK), receptor-like kinases (RLK) and bone marrow kinase on chromosome X (BMX)). Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful for treating a variety of diseases, disorders or conditions, associated with abnormal cellular responses triggered by protein kinase-mediated events. Compounds provided by this invention are also useful for the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.