6-[4]Pyridyl-chinolin | 21863-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-[4]Pyridyl-chinolin
• 英文别名: 6-pyridin-4-yl-quinoline；6-[4]pyridyl-quinoline；6-Pyridin-4-ylquinoline；6-pyridin-4-ylquinoline
• CAS: 21863-24-1
• 化学式: C₁₄H₁₀N₂
• 分子量: 206.247
• InChiKey: IJTZLIDTWCNUAR-UHFFFAOYSA-N

物化性质

• 熔点：
  102-103 °C(Solvent: Heptane)
• 沸点：
  369.1±22.0 °C(predicted)
• 密度：
  1.176±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-溴喹啉 、 吡啶-4-硼酸 在 四(三苯基膦)钯 、 sodium carbonate decahydrate 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 反应 20.0h， 以81.3%的产率得到6-[4]Pyridyl-chinolin
  参考文献：
  名称：

  COMPOSITION FOR ACTIVATING NEUROGENESIS

  摘要：

  公开号：

  EP3508223B1

文献信息

• Composition for activating neurogenesis
  申请人：KYOTO UNIVERSITY

  公开号：US11318126B2

  公开（公告）日：2022-05-03

  Provided is a composition for activating neurogenesis, use of the composition, and a method for preventing, improving, inhibiting the development of, and/or treating a disease or the like of the central nervous system and or the peripheral nervous system using the composition. A composition for activating neurogenesis contains, as an active ingredient, a compound having an ability to inhibit phosphorylation activity of a protein kinase or a prodrug thereof, or a pharmaceutically acceptable salt thereof, and a composition for preventing, improving, inhibiting the development of, and/or treating a disease of the central nervous system and/or the peripheral nervous system, or for improving, inhibiting the development of, and/or treating a functional disorder of the central nervous system and/or the peripheral nervous system, the composition containing, as an active ingredient, a compound having an ability to inhibit phosphorylation activity of a protein kinase or a prodrug thereof, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种用于激活神经发生的组合物，该组合物的用途，以及使用该组合物预防、改善、抑制中枢神经系统和/或周围神经系统疾病或类似疾病的发展和/或治疗的方法。一种用于激活神经发生的组合物，作为活性成分，含有一种具有抑制蛋白激酶磷酸化活性能力的化合物或其原药，或其药学上可接受的盐，以及一种用于预防、改善、抑制中枢神经系统和/或周围神经系统疾病的发展和/或治疗疾病的组合物、或用于改善、抑制发展和/或治疗中枢神经系统和/或周围神经系统的功能紊乱，该组合物含有作为活性成分的具有抑制蛋白激酶磷酸化活性的化合物或其原药，或其药学上可接受的盐。
• Coates et al., Journal of the Chemical Society, 1943, p. 401,403
  作者：Coates et al.

  DOI：——

  日期：——
• PHARMACEUTICAL COMPOSITION AND TREATMENT METHOD FOR GENETIC DISEASE ASSOCIATED WITH SPLICING ABNORMALITIES
  申请人：KYOTO UNIVERSITY

  公开号：US20200113907A1

  公开（公告）日：2020-04-16

  A pharmaceutical composition for genetic diseases caused by an aberrant splicing regulation is provided. Provided are a pharmaceutical composition for preventing, ameliorating, suppressing progression of, and/or treating the genetic diseases caused by an aberrant splicing regulation, the pharmaceutical composition containing, as an active ingredient, a compound capable of suppressing an aberrant splicing regulation that contributes to the development or progression of genetic diseases caused by an aberrant splicing regulation, and a method for preventing, ameliorating, suppressing progression of, and/or treating the genetic diseases using a compound capable of suppressing an aberrant splicing regulation that contributes to the development or progression of genetic diseases caused by an aberrant splicing regulation.
• COMPOSITION FOR ACTIVATING NEUROGENESIS
  申请人：Kyoto University

  公开号：EP3508223B1

  公开（公告）日：2022-05-04