tris-(acetylsulfanylmethyl)-mesitylene | 398469-81-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tris-(acetylsulfanylmethyl)-mesitylene
• 英文别名: S-[[3,5-bis(acetylsulfanylmethyl)-2,4,6-trimethylphenyl]methyl] ethanethioate
• CAS: 398469-81-3
• 化学式: C₁₈H₂₄O₃S₃
• 分子量: 384.585
• InChiKey: GTBRGOOEUYORHW-UHFFFAOYSA-N

物化性质

• 沸点：
  510.8±50.0 °C(Predicted)
• 密度：
  1.203±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  127
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,4,6-三溴甲基三甲基苯 、 potassium thioacetate 以 N,N-二甲基甲酰胺 为溶剂， 以4%的产率得到1-acetylsulfanylmethyl-3,5-bis(bromomethyl)-2,4,6-trimethyl-benzene
  参考文献：
  名称：

  WO2006/55437

  摘要：

  公开号：

文献信息

• Synthesis and use of glycodendrimer reagents
  申请人：——

  公开号：US20020019039A1

  公开（公告）日：2002-02-14

  The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.

  本发明涉及一种化学修饰的突变蛋白，其中包括将半胱氨酸残基替换为前体蛋白中的其他残基，所替换的半胱氨酸残基随后通过与糖基化硫代磺酸盐反应而被修饰。还提供了一种生产该化学修饰的突变蛋白的方法。本发明还涉及一种糖基化的甲烷硫代磺酸盐。本发明的另一个方面是一种修改蛋白的功能特性的方法，包括提供蛋白并将蛋白与糖基化的甲烷硫代磺酸盐试剂在有效条件下反应，以产生具有与蛋白相比改变的功能特性的糖蛋白。此外，本发明涉及确定化学修饰的突变蛋白的结构-功能关系的方法。本发明还涉及用于产生硫代糖的合成方法，以及所产生的硫代糖，以及用于产生糖基树状聚合物试剂的方法。
• EP1373285A4
  申请人：——

  公开号：EP1373285A4

  公开（公告）日：2009-09-09
• SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS
  申请人：GENENCOR INTERNATIONAL, INC.

  公开号：EP1373285A2

  公开（公告）日：2004-01-02
• US6627744B2
  申请人：——

  公开号：US6627744B2

  公开（公告）日：2003-09-30
• [EN] SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS<br/>[FR] SYNTHESE ET UTILISATION DE REACTIFS A GLYCODENDRIMERES
  申请人：GENENCOR INT

  公开号：WO2002079394A2

  公开（公告）日：2002-10-10

  The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.