N,N,N'-Trimethylbenzidine | 2655-66-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N,N'-Trimethylbenzidine
• 英文别名: N,N,N'-trimethyl-benzidine；N,N,N'-Trimethyl-benzidin；N,N,N'-Trimethyl-benzidin；N,N-dimethyl-N'-methylbenzidine；4-[4-(dimethylamino)phenyl]-N-methylaniline
• CAS: 2655-66-5
• 化学式: C₁₅H₁₈N₂
• 分子量: 226.321
• InChiKey: OQCDRCTWIBWMJL-UHFFFAOYSA-N

物化性质

• 沸点：
  384.6±35.0 °C(Predicted)
• 密度：
  1.066±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N,N'-Trimethylbenzidine 在 lithium aluminium tetrahydride 作用下， 以 乙醚 、 苯 为溶剂， 反应 72.0h， 生成 N-Octyl-N,N',N'-trimethylbenzidine
  参考文献：
  名称：

  N-烷基-N，N'，N'-三甲基联苯胺在阴离子和阳离子胶束中的光电离的电子自旋共振，电子自旋回波调制和电子核双共振研究

  摘要：

  N-Alkyl-N,N',N'-trimethylbenzidines (C(n)TMB, n = 1-6, 8) were synthesized and photoionized in rapidly frozen anionic and cationic micelles. The photoyields of the cation radicals were investigated by electron spin resonance spectroscopy. Electron spin echo modulation spectroscopy and proton matrix electron nuclear double resonance were used to determine the relative location of the photoproduced cation radical with respect to the deuterated aqueous interface. No dependence on the photoyield as a function of the electron donor alkyl chain length is observed, although increasing the alkyl chain length on the benzidine moiety moves its location toward the aqueous interface. The lack of a photoyield trend is interpreted in terms of the solubilization geometry, which determines the paths of electron escape to form charge-separated products. An electron escape cone defined as the solid angle formed from the center of the electron donor moiety through the width of the spin distribution that intersects the interface changes only slowly as a function of radical location over a limited range. Hence, the photoyield is little changed.

  DOI：

  10.1021/j100121a054
• 作为产物：
  描述：

  N,N-Dimethyl-benzidin 在 吡啶 、 sodium hydroxide 、 氢溴酸 、 丙酮 、 苯酚 作用下， 生成 N,N,N'-Trimethylbenzidine
  参考文献：
  名称：

  Hanousek; Matrka, Collection of Czechoslovak Chemical Communications, 1957, vol. 22, p. 1464,1466

  摘要：

  DOI：

文献信息

• Reactive intermediates-induced potential responses of a polymeric membrane electrode for ultrasensitive potentiometric biosensing
  作者：Xuewei Wang、Wei Qin

  DOI：10.1039/c2cc31020a

  日期：——

  Reactive intermediates rather than stable reactants or products have been found to induce large potential responses on an appropriately formulated polymeric membrane electrode, which provides a novel methodology for ultrasensitive potentiometric biosensing based on the horseradish peroxidase-H2O2 oxidation reaction.

  已发现反应中间体而不是稳定的反应物或产物在适当配制的聚合物膜电极上诱导大电位响应，这为基于辣根过氧化物酶-H2O2氧化反应的超灵敏电位生物传感提供了一种新方法。
• Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease
  申请人：Jin Lee-Way

  公开号：US20070254889A1

  公开（公告）日：2007-11-01

  The present invention is directed to pharmaceutical compositions comprising one or more compounds of Formulae I, II, III, IV, V, VI, VII, VIII, IX and X, or pharmaceutically acceptable salts thereof and excipients. The present invention provides a method of inhibiting β-amyloid plaque aggregation, the method comprising introducing into a mammal an aggregation-inhibiting amount of a compound of Formula I, II, III, IV, V, VI, VII, VIII, IX or X or a pharmaceutically acceptable salt, ester, amide or prodrug thereof. By inhibiting amyloid aggregation, this method is capable of rescuing cells that otherwise would be susceptible or further damaged by amyloidosis.

  本发明涉及一种制药组合物，包括式I、II、III、IV、V、VI、VII、VIII、IX和X中的一个或多个化合物，或其药学上可接受的盐和辅料。本发明提供了一种抑制β-淀粉样斑块聚集的方法，该方法包括向哺乳动物中引入式I、II、III、IV、V、VI、VII、VIII、IX或X中的一种化合物或其药学上可接受的盐、酯、酰胺或前药的抑制聚集量。通过抑制淀粉样聚集，该方法能够挽救那些本来易受淀粉样蛋白病损伤的细胞。
• Biphenyls and fluorenes as imaging agents in alzheimer's disease
  申请人：Kung F. Hank

  公开号：US20050271584A1

  公开（公告）日：2005-12-08

  This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.

  本发明涉及成像淀粉样沉积物的方法、标记化合物及制备标记化合物的方法。本发明还涉及抑制淀粉样蛋白聚集形成淀粉样沉积物的化合物及制备化合物的方法，以及向淀粉样沉积物传递治疗剂的方法。
• Electrochromic device
  申请人：Nippon Mitsubishi Oil Corporation

  公开号：EP0995786A1

  公开（公告）日：2000-04-26

  The electrochromic device which has an ion conductive layer obtained by curing a composition comprising (a) a bipyridinium compound represented by formula (1), (b) a specific amine compound and (c) a precursor component of a polymeric solid electrolyte, disposed between two electrically conductive substrates at least one of which is transparent, said formula (1) being wherein X- and Y- are the same or different and are each independently a counter anion selected from the group consisting of an halogen anion, ClO4-, BF4-, PF6-, CH3COO- and CH3(C6H4)SO3-, R1 is hydrogen or a C1 - C5 alkyl group, R2 is a C1 - C30 divalent hydrocarbon or oxygen-containing hydrocarbon group, R3 is a C1 - C20 hydrocarbon or oxygen-containing hydrocarbon group and a is an integer of 0 or 1.

  电致变色装置，其离子导电层是通过固化一种组合物而获得的，该组合物包括(a) 由式(1)表示的联吡啶鎓化合物，(b) 特定胺化合物和(c) 聚合物固体电解质的前体组分，置于两个导电基底之间，其中至少有一个基底是透明的、 所述式（1）为 其中 X- 和 Y- 相同或不同，且各自独立地为选自卤素阴离子、ClO4-、BF4-、PF6-、CH3COO- 和 CH3(C6H4)SO3- 的反阴离子，R1 为氢或 C1 - C5 烷基，R2 为 C1 - C30 二价烃或含氧烃基，R3 为 C1 - C20 烃或含氧烃基，a 为 0 或 1 的整数。
• ELECTROCHROMIC ELEMENT
  申请人：Nippon Mitsubishi Oil Corporation

  公开号：EP1041425A1

  公开（公告）日：2000-10-04

  An electrochromic element composed of an electrochromic layer comprising a specified electrically conductive polymer and an ionically conductive substance layer containing a viologen compound, both sandwiched between two electrically conductive substrates at least one of which is transparent.

  一种电致变色元件，由电致变色层和离子导电物质层组成，电致变色层包括特定的导电聚合物和含有紫罗兰烯化合物的离子导电物质层，两者夹在两个导电基底之间，其中至少有一个基底是透明的。