N,N-diallyl-lactamide | 5422-38-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-diallyl-lactamide
• 英文别名: N,N-Diallyl-lactamid；Milchsaeure-diallylamid；N,N-diallyl-2-hydroxypropanamide；2-hydroxy-N,N-bis(prop-2-enyl)propanamide
• CAS: 5422-38-8
• 化学式: C₉H₁₅NO₂
• 分子量: 169.224
• InChiKey: RYDSICAGQMSXNW-UHFFFAOYSA-N

物化性质

• 沸点：
  111 °C(Press: 5.0 Torr)
• 密度：
  1.0115 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乳酸 、 二烯丙基胺 在 xylene 作用下， 生成 N,N-diallyl-lactamide
  参考文献：
  名称：

  N-Substituted Lactamides

  摘要：

  DOI：

  10.1021/ja01105a022

文献信息

• [EN] METHOD FOR THE MANUFACTURE OF N, N-DIALLKYLLACTAMIDE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE N,N-DIALKYLLACTAMIDE
  申请人：PURAC BIOCHEM BV

  公开号：WO2016050894A1

  公开（公告）日：2016-04-07

  The invention relates to a method for the manufacture of N,N-dialkyllactamide, whereby at least one of the compounds selected from the series consisting of alkyl lactate, lactide and polylactic acid is mixed with dialkylamine in order to form a reaction mixture, under conditions whereby aminolysis takes place in the reaction mixture. The method is characterized in that the reaction mixture further comprises a Lewis acid. As a result of the invented method, N,N-dialkyllactamides can be manufactured in high yields and with high optical purity.

  本发明涉及一种制备N,N-二烷基内酰胺的方法，其中从由烷基乳酸酯、乳酸内酯和聚乳酸组成的系列中至少选择一种化合物与二烷基胺混合，以形成反应混合物，在反应混合物中进行胺解反应。该方法的特征在于，反应混合物还包括一种路易斯酸。由于该发明方法，N,N-二烷基内酰胺可以高产率、高光学纯度地制备。
• [EN] PROCESS FOR MANUFACTURING N,N-DIALKYL LACTAMIDE<br/>[FR] PROCÉDÉ POUR LA FABRICATION DE N,N-DIALKYLLACTAMIDE
  申请人：PURAC BIOCHEM BV

  公开号：WO2010037776A1

  公开（公告）日：2010-04-08

  The present invention pertains to a process for manufacturing dialkyl lactamide comprising the steps of reacting lactide and dialkylamine selected from one or more of dimethylamine, diethylamine, and methylethylamine to form a reaction mixture which comprises dialkyl lactamide selected from N, N-dimethyl lactamide, N,N-diethyl lactamide, and N,N-methylethyl lactamide, N,N-dialkyl lactoyl lactamide, and dialkylamine, subjecting the reaction mixture to a separation step to form a product stream comprising N,N-dialkyl lactamide, a first recycle stream comprising dialkylamine and a second recycle stream comprising N,N-dialkyl lactoyl lactamide, feeding the recycle streams to the reaction step, and isolating the product stream. The process allows the manufacture of N, N-dimethyl lactamide, N,N-diethyl lactamide, and N,N-methylethyl lactamide on commercial scale.

  本发明涉及一种制造二烷基内酰胺的方法，包括以下步骤：将内酯和二烷基胺（所选自二甲胺、二乙胺和甲乙胺）反应，形成反应混合物，其中包括所选自N，N-二甲基内酰胺、N，N-二乙基内酰胺、N，N-甲乙基内酰胺、N，N-二烷基内酰基内酰胺和二烷基胺的二烷基内酰胺；将反应混合物经过分离步骤，形成产品流，其中包括N，N-二烷基内酰胺、第一循环流，包括二烷基胺和第二循环流，包括N，N-二烷基内酰基内酰胺；将循环流送回反应步骤，隔离产品流。该方法允许商业化生产N，N-二甲基内酰胺、N，N-二乙基内酰胺和N，N-甲乙基内酰胺。
• Method for the manufacture of N,N-dialkyllactamide
  申请人：PURAC BIOCHEM BV

  公开号：US10144702B2

  公开（公告）日：2018-12-04

  A method for the manufacture of N,N-dialkyllactamide, whereby at least one of the compounds selected from the series made of alkyl lactate, lactide and polylactic acid is mixed with dialkylamine in order to form a reaction mixture, under conditions whereby aminolysis takes place in the reaction mixture. The method is characterized in that the reaction mixture further includes a Lewis acid. As a result of the method, N,N-dialkyllactamides can be manufactured in high yields and with high optical purity.

  一种制造 N,N-二烷基内酰胺的方法，其中至少一种选自烷基乳酸、内酰胺和聚乳酸系列的化合物与二烷基胺混合，以形成反应混合物，在反应混合物中发生氨解反应。该方法的特点是反应混合物中还包括一种路易斯酸。通过该方法，可以生产出产率高、光学纯度高的 N,N-二烷基内酰胺。
• Chromatography membranes formed by thiol-ene or thiol-yne click polymerization reactions
  申请人：Natrix Separations Inc.

  公开号：US10357766B2

  公开（公告）日：2019-07-23

  Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.

  所公开的是复合材料及其制造方法。复合材料包括支撑件和交联凝胶，其中交联凝胶是通过巯基烯或巯基炔聚合和交联合成的聚合物。交联凝胶可以通过巯基烯或巯基炔接枝反应进行功能化，可以与聚合反应同时进行，也可以作为两步法中的第二步。这种复合材料可用作色谱分离介质。
• Methods of separating substances from fluids
  申请人：Merck Millipore Ltd.

  公开号：US10864510B2

  公开（公告）日：2020-12-15

  Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.

  所公开的是复合材料及其制造方法。复合材料包括支撑件和交联凝胶，其中交联凝胶是通过巯基烯或巯基炔聚合和交联合成的聚合物。交联凝胶可以通过巯基烯或巯基炔接枝反应进行功能化，可以与聚合反应同时进行，也可以作为两步法中的第二步。这种复合材料可用作色谱分离介质。