2-[癸酰基(甲基)氨基]乙酸 | 2671-91-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-[癸酰基(甲基)氨基]乙酸
• 英文名称: N-decanoyl sarcosine
• 英文别名: N-decanoyl-N-methyl-glycine；N-Decanoyl-N-methyl-glycin；N-decanoylsarcosine；Caproyl sarcosine；2-[decanoyl(methyl)amino]acetic acid
• CAS: 2671-91-2
• 化学式: C₁₃H₂₅NO₃
• mdl: MFCD01097255
• 分子量: 243.346
• InChiKey: LERPQJNGDVCXSI-UHFFFAOYSA-N

物化性质

• 熔点：
  37.5-38.5 °C
• 沸点：
  386.4±25.0 °C(Predicted)
• 密度：
  1.005±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.846
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  sodium sarcosinate 、 癸酰氯 以 水 为溶剂， 反应 1.0h， 生成 2-[癸酰基(甲基)氨基]乙酸
  参考文献：
  名称：

  Iyer, Venkataraman N.; Sheth, Geeta N.; Subrahmanyam, V. V. R., Journal of the Indian Chemical Society, 1982, vol. 59, # 7, p. 856 - 859

  摘要：

  DOI：

文献信息

• Preparation of N-acyl amino carboxylic acids, amino carboxylic acids and their derivatives by metal-catalyzed carboxymethylation in the presence of a promoter
  申请人：——

  公开号：US20020058834A1

  公开（公告）日：2002-05-16

  A process for the preparation of amino carboxylic acids, N-acyl amino carboxylic acids, or derivatives thereof by carboxymethylation of an amide, amide precursor or amide source compound in the presence of a carboxymethylation catalyst precursor and a promoter is provided. A carboxymethylation reaction mixture is formed by introducing a promoter, an amide, amide precursor or amide source compound, carbon monoxide, hydrogen, an aldehyde or aldehyde source compound, and a carboxymethylation catalyst precursor into a carboxymethylation reaction zone. In a preferred embodiment, the promoter is a supported noble metal promoter. In another preferred embodiment, the amide compound and aldehyde are selected to yield an N-acyl amino carboxylic acid which is readily converted to N-phosphonomethyl)glycine, or a salt or ester thereof.

  提供了一种通过在存在羧甲基化催化剂前体和促进剂的情况下，通过羧甲基化酰胺、酰胺前体或酰胺源化合物的羧甲基化制备氨基羧酸、N-酰基氨基羧酸或其衍生物的方法。通过将促进剂、酰胺、酰胺前体或酰胺源化合物、一氧化碳、氢气、醛或醛源化合物以及羧甲基化催化剂前体引入羧甲基化反应区域形成羧甲基化反应混合物。在一种首选实施例中，促进剂是支持的贵金属促进剂。在另一种首选实施例中，所选的酰胺化合物和醛可产生一种易于转化为N-磷酸甲基)甘氨酸或其盐或酯的N-酰基氨基羧酸。
• PROTEIN REFORMING METHOD
  申请人：Ajinomoto Co., Inc.

  公开号：EP2281827A1

  公开（公告）日：2011-02-09

  The present invention provides a method for producing a protein which has restored a higher-order structure of a native state thereof: by bringing the protein which has lost a higher-order structure thereof into contact at pH 6.5 to 9.0 to a 1 to 3% aqueous solution of a specific surfactant, such as lauroylglutamic acid to obtain a solubilized solution of the protein; and adding the obtained solubilized solution to a buffer with pH 6.5 to 9.0 containing arginine or an arginine derivative at a level of 0.1 to 1.2 M to lower the concentration of the specific surfactant, such as lauroylglutamic acid, in an obtained mixture solution down to 0.02 to 0.275%. According to the present invention, it is possible to easily restore a higher-order structure of a native state of a protein while smoothly detaching a surfactant from the protein.

  本发明提供了一种生产恢复了原生态高阶结构的蛋白质的方法：将失去高阶结构的蛋白质在pH6.5至9.0的特定表面活性剂（如月桂酰谷氨酸）的1%至3%的水溶液接触，以获得该蛋白质的增溶溶液；并将所获得的增溶溶液加入pH值为6.5至9.0的缓冲液中，该缓冲液中含有0.1至1.2M的精氨酸或精氨酸衍生物，以将所获得的混合物溶液中的特定表面活性剂（如月桂酰谷氨酸）的浓度降至0.02%至0.275%。根据本发明，可以在使表面活性剂与蛋白质顺利分离的同时，轻松恢复蛋白质原生状态的高阶结构。
• Pharmaceutical formulations for the oral delivery of peptide or protein drugs
  申请人：Cyprumed GmbH

  公开号：EP3006045A1

  公开（公告）日：2016-04-13

  The present invention relates to improved pharmaceutical formulations, uses and methods for the oral delivery of peptide or protein drugs with advantageously high bioavailability, safety and cost-effectiveness. In particular, the invention provides a peptide or protein drug having a molecular weight of equal to or less than about 50 kDa for use as a medicament, wherein said peptide or protein drug is to be administered orally in combination with a pharmaceutically acceptable copper salt/complex and/or a pharmaceutically acceptable zinc salt/complex, and with a pharmaceutically acceptable reducing agent. The invention also provides a pharmaceutical composition comprising: a peptide or protein drug having a molecular weight of equal to or less than about 50 kDa; a pharmaceutically acceptable copper salt/complex and/or a pharmaceutically acceptable zinc salt/complex; and a pharmaceutically acceptable reducing agent.

  本发明涉及肽或蛋白质药物口服给药的改进药物制剂、用途和方法，具有生物利用度高、安全性好和成本效益高等优点。特别是，本发明提供了一种分子量等于或小于约 50 kDa 的多肽或蛋白质药物，可用作药物，其中所述多肽或蛋白质药物将与药学上可接受的铜盐/络合物和/或药学上可接受的锌盐/络合物以及药学上可接受的还原剂一起口服给药。本发明还提供了一种药物组合物，其中包括：分子量等于或小于约 50 kDa 的多肽或蛋白药物；药学上可接受的铜盐/络合物和/或药学上可接受的锌盐/络合物；以及药学上可接受的还原剂。
• AMADORIASE HAVING IMPROVED ANIONIC-SURFACTANT RESISTANCE
  申请人：Kikkoman Corporation

  公开号：EP3216865A1

  公开（公告）日：2017-09-13

  The present invention provides a composition that enables measurement of glycated hemoglobin in the presence of a stronger surfactant than conventional surfactants. To this end, the present invention provides an amadoriase in which one or more amino acids have been substituted at positions corresponding to positions selected from the group consisting of positions 80, 71, 175, 172, 279, 12, 9, 77, 30, 28, 13, 3, 4, 286, 204, 338, 44, 340, and 194 of the amadoriase derived from the genus Coniochaeta having the amino acid sequence as shown in SEQ ID NO: 1 as well as a composition for measurement of glycated hemoglobin comprising an amadoriase that retains activity in the presence of an anionic surfactant. The present invention can provide an enzyme and a composition for measurement of glycated hemoglobin that sufficiently remain stable even when exposed to anionic surfactants.

  本发明提供了一种组合物，该组合物能够在比传统表面活性剂更强的表面活性剂存在下测量糖化血红蛋白。为此，本发明提供了一种氨甲蝶呤酶，其中一个或多个氨基酸在与选自具有 SEQ ID NO：1 所示氨基酸序列的氨甲蝶呤酶，以及一种用于测量糖化血红蛋白的组合物，该组合物包含一种在阴离子表面活性剂存在下仍能保持活性的氨甲蝶呤酶。本发明可提供一种用于测量糖化血红蛋白的酶和组合物，即使暴露于阴离子表面活性剂中也能充分保持稳定。
• METHOD FOR RECOVERING NUCLEIC ACID
  申请人：Toray Industries, Inc.

  公开号：EP3733846A1

  公开（公告）日：2020-11-04

  A method according to the present invention is a method that utilizes an aluminum oxide support with a water-soluble neutral polymer adsorbed on a surface of the aluminum oxide support and is aimed to collect nucleic acids from a body fluid sample. The method includes a step of adsorbing nucleic acids on the support in the presence of a chaotropic agent and a step of adding a solution containing an anionic surfactant to the nucleic acid-adsorbed support.

  根据本发明的方法，是一种利用氧化铝支架和吸附在氧化铝支架表面的水溶性中性聚合物，从体液样品中收集核酸的方法。该方法包括在混沌剂存在的情况下将核酸吸附在载体上的步骤，以及将含有阴离子表面活性剂的溶液添加到核酸吸附的载体上的步骤。