Ethyl 4-methyl-6-phenyl-2-sulfanylpyrimidine-5-carboxylate | 1257325-72-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Ethyl 4-methyl-6-phenyl-2-sulfanylpyrimidine-5-carboxylate
• 英文别名: ethyl 6-methyl-4-phenyl-2-sulfanylidene-1H-pyrimidine-5-carboxylate
• CAS: 1257325-72-6
• 化学式: C₁₄H₁₄N₂O₂S
• 分子量: 274.343
• InChiKey: URCKOSRSIYJPIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  82.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-甲基-4-苯基-2-硫代-1,2,3,4-四氢嘧啶-5-羧酸乙酯 以 二甲基亚砜 为溶剂， 反应 0.08h， 以80%的产率得到Ethyl 4-methyl-6-phenyl-2-sulfanylpyrimidine-5-carboxylate
  参考文献：
  名称：

  Facile aromatization of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) by iodine

  摘要：

  A facile aromatization of 3,4-dihydropyrimidin-2(1H)-ones using iodine in dimethyl sulfoxide under microwave irradiation was carried out which is more efficient and gives high yield in less time; presently it is the most important catalyst for dehydrogenation. (C) 2012 Manisha M. Kodape. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2012.10.015

文献信息

• Facile aromatization of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) by iodine
  作者：Manisha M. Kodape、Anand S. Aswar、Nandkishor D. Gawhale、Vivek T. Humne、Bilal Ahmad Mir

  DOI：10.1016/j.cclet.2012.10.015

  日期：2012.12

  A facile aromatization of 3,4-dihydropyrimidin-2(1H)-ones using iodine in dimethyl sulfoxide under microwave irradiation was carried out which is more efficient and gives high yield in less time; presently it is the most important catalyst for dehydrogenation. (C) 2012 Manisha M. Kodape. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.