1-Brom-2-cyclobutyliden-ethan | 24927-33-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: 1-Brom-2-cyclobutyliden-ethan
• 英文别名: 1-Bromo-2-cyclobutyliden-ethan；1-bromo-2-cyclobutylidene-ethane；2-bromoethylidenecyclobutane；(2-Bromoethylidene)cyclobutane
• CAS: 24927-33-1
• 化学式: C₆H₉Br
• mdl: MFCD20622567
• 分子量: 161.041
• InChiKey: BBLAJMQEKRCPGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-Brom-2-cyclobutyliden-ethan 在 potassium carbonate 、 间氯过氧苯甲酸 、 potassium iodide 作用下， 以 二氯甲烷 、 水 、 丙酮 为溶剂， 反应 0.7h， 生成 (3R,3a'S,9a'S,10a'S)-7-((1-oxaspiro[2.3]hexan-2-yl)methoxy)-6-hydroxy-1',1',12'-trimethyl-6',7',8',9',10',10a'-hexahydro-1'H,3'H,4'H-spiro[indoline-3,2'-[3a,9a](epiminomethano)cyclopenta[b]quinolizine]-2,11'-dione
  参考文献：
  名称：

  C26 DIALKYL AND SPIROALKYL ANALOGS OF MARCFORTINE A

  摘要：

  The C26 dimethyl dioxepinoindole ring found in marcfortine A is unique among natural products. In order to ascertain the importance of the dimethyl moiety to anthelmintic activity, we prepared a variety of C26-dialkyl and spiroalkyl analogs. They include cyclobutyl, cyclohexyl, diethyl, and ethyl-methyl derivatives. This communication describes the synthesis of these compounds. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00224-2
• 作为产物：
  描述：

  2-cyclobutylideneethanol 在 三溴化磷 作用下， 以 乙醚 为溶剂， 生成 1-Brom-2-cyclobutyliden-ethan
  参考文献：
  名称：

  通过分子内烯丙基氢胺化电催化获得氮杂环丁烷：通过电化学动力学分析仔细检查关键氧化步骤

  摘要：

  氮杂环丁烷是生物活性分子、药物化学和过渡金属配体设计中的重要结构支架。然而，最先进的方法不能应用于烯丙胺衍生物的分子内加氢胺化，尽管它们具有作为氮杂环丁烷最普遍的合成前体之一的潜在潜力。在此，我们首次报道了一种烯丙基磺酰胺分子内氢胺化的电催化方法，以获取氮杂环丁烷。钴催化和电的结合使得关键碳阳离子中间体的区域选择性生成成为可能，该中间体可以直接形成分子内C-N键。包括电化学动力学分析在内的机理研究表明，通过亲核环化进行的催化剂再生或获得碳阳离子中间体的第二次电化学氧化都参与了我们电化学方案的速率决定步骤（RDS），并强调了电化学提供理想反应的能力。是指介导催化剂氧化。

  DOI：

  10.1021/jacs.3c03172

文献信息

• Novel lincomycin derivatives possessing antimicrobial activity
  申请人：Lewis G. Jason

  公开号：US20050043248A1

  公开（公告）日：2005-02-24

  Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

  新型的林可霉素衍生物被披露。这些林可霉素衍生物表现出抗菌活性。本发明的化合物可能对细菌，包括革兰氏阳性生物，表现出强效活性，并且可能是有用的抗微生物药剂。该化合物的合成和使用方法也被披露。
• Novel lincomycin derivatives possessing antibacterial activity
  申请人：Lewis G. Jason

  公开号：US20050215488A1

  公开（公告）日：2005-09-29

  Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

  新型的林可霉素衍生物已被披露。这些林可霉素衍生物表现出抗菌活性。本发明的化合物可能对细菌，包括革兰氏阳性生物，表现出强效活性，并可能是有用的抗微生物药剂。该化合物的合成和使用方法也已被披露。
• Lincomycin derivatives possessing antibacterial activity
  申请人：VICURON PHARMACEUTICALS INC.

  公开号：US20040230046A1

  公开（公告）日：2004-11-18

  Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

  揭示了新颖的林可霉素衍生物。这些林可霉素衍生物表现出抗菌活性。由于本发明的化合物对细菌，包括革兰氏阳性生物，表现出强大的活性，它们是有用的抗微生物药剂。还公开了这些化合物的合成和使用方法。
• Benzopiperidine derivatives
  申请人：Eisai Co., Ltd.

  公开号：US20040092737A1

  公开（公告）日：2004-05-13

  Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: 1 wherein the variables are as described in the specification. These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and rejection reaction accompanying organ transplantation.

  式（I）所表示的苯并哌啶衍生物及其盐或水合物，制备该化合物的方法和包含该化合物的药物：1其中，变量如规范所述。这些化合物在预防和治疗各种炎症性疾病和免疫性疾病方面具有药效，例如类风湿性关节炎、特应性皮炎、银屑病、哮喘和器官移植伴随的排斥反应。
• Cyclopropanecarboxylic acids and esters
  申请人：Roussel-UCLAF

  公开号：US03997586A1

  公开（公告）日：1976-12-14

  Novel cyclopropanecarboxylic acids and esters of the formula ##STR1## wherein Z.sub.1 and Z.sub.2 are selected from the group consisting of hydrogen, alkyl, aralkyl, aryl, alkenyl non-conjugated with the cyclopropane ring, alkenyl non-conjugated with the cyclopropane ring, cycloalkyl, cycloalkenyl and heterocyclic; R is selected from the group consisting of OH and OR' in which R' is selected from the group consisting of lower alkyl which may be substituted, benzyl which may be substituted on the phenyl or methylene portion, N-methylene-dicarboximide, (5-benzyl-furyl-3) methyl, and a cyclopentene of the formula ##STR2## WHEREIN R" is selected from the group consisting of alkyl, alkynyl, alkenyl, aryl, aralkyl, cycloalkyl, cycloalkenyl and heterocyclic; A is a bivalent alkyl radical selected from the group consisting of ##STR3## WHEREIN R.sub.1 is selected from the group consisting of hydrogen and lower alkyl, R.sub.2 and R.sub.3 are selected from the group consisting of alkyl, alkynyl, alkenyl, aryl, aralkyl, cycloalkyl, cycloalkenyl and heterocyclic and taken together with the carbon atom to which they are attached form a ring selected from the group consisting of carbon homo rings and unsaturated carbon homo rings of 3 to 7 carbon atoms and heterocyclic rings which may be substituted with lower alkyl or lower alkoxy and R.sub.2 and R.sub.3 may together form a polycyclic aromatic radical, R.sub.4 is lower alkyl, R.sub.5 is selected from the group consisting of hydrogen and lower alkyl and R.sub.4 and R.sub.5 together with the carbon atoms to which they are attached may form a saturated or unsaturated carbon homo ring or a heterocyclic ring, Y is selected from the group consisting of methylene and a saturated or unsaturated carbon chain and Y' is selected from the group consisting of methine and a saturated or unsaturated carbon chain with the proviso that when Z.sub.1 and Z.sub.2 are methyl and R.sub.1 is hydrogen, R.sub.2 is other than methyl and their preparation.

  化合物的名称为新型环丙烷羧酸和酯，其化学式为##STR1## 其中Z.sub.1和Z.sub.2的取值包括氢、烷基、芳基烷基、芳基、非与环丙烷环共轭的烯基、非与环丙烷环共轭的烯基、环烷基、环烯基和杂环基；R的取值包括OH和OR'，其中R'的取值包括可被取代的低烷基、苯甲基（苯环或亚甲基部分可被取代）、N-亚甲基双酰亚胺、（5-苯甲基呋喃-3）甲基和化学式为##STR2## 其中R"的取值包括烷基、炔基、烯基、芳基、芳基烷基、环烷基、环烯基和杂环基；A是一种二价烷基基团，其取值包括##STR3## 其中R.sub.1的取值包括氢和低烷基，R.sub.2和R.sub.3的取值包括烷基、炔基、烯基、芳基、芳基烷基、环烷基、环烯基和杂环基，并且它们与它们附着的碳原子一起形成3到7个碳原子的碳同族环和不饱和碳同族环和可被取代的杂环，R.sub.2和R.sub.3可以一起形成多环芳香基团，R.sub.4是低烷基，R.sub.5的取值包括氢和低烷基，R.sub.4和R.sub.5与它们附着的碳原子一起可以形成饱和或不饱和的碳同族环或杂环，Y的取值包括亚甲基和饱和或不饱和的碳链，Y'的取值包括亚甲基和饱和或不饱和的碳链，但当Z.sub.1和Z.sub.2为甲基且R.sub.1为氢时，R.sub.2不为甲基。