2-丁基-1H-哒嗪-3,6-二酮 | 6941-31-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2-丁基-1H-哒嗪-3,6-二酮
• 英文名称: 2-Butyl-6-hydroxy-2H-pyridazinon-(3)
• 英文别名: 3-Hydroxy-1-butyl-pyridazon-6；2-Butyl-6-hydroxy-3-oxo-2H-pyridazin；1-butyl-1,2-dihydro-pyridazine-3,6-dione；2-butyl-1H-pyridazine-3,6-dione
• CAS: 6941-31-7
• 化学式: C₈H₁₂N₂O₂
• 分子量: 168.195
• InChiKey: QXCSFWKFVLOAQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(3-氧代丁基)-1,2-二氢-3,6-哒嗪二酮 在 sodium hydroxide 、 一水合肼 、 二乙二醇 作用下， 生成 2-丁基-1H-哒嗪-3,6-二酮
  参考文献：
  名称：

  The Chemistry of Maleic Hydrazide. II.¹ The Course of the Michael-type Addition²

  摘要：

  DOI：

  10.1021/ja01554a075

文献信息

• Thiazole derivative and pharmaceutical use thereof
  申请人：Tsutsumi Hideo

  公开号：US20050004134A1

  公开（公告）日：2005-01-06

  A thiazole derivative of the formula (I): wherein R is a 1-optionally substituted-6-oxo-1,6-dihydro-3-pyridazinyl, R′ is an optionally substituted phenyl, and R 2 is hydrogen, a group of the formula (i): wherein R 4 is hydrogen, lower alkyl or lower alkenyl, and R 5 is hydrogen, optionally substituted lower alkyl, acyl, cyclo(lower)alkyl, lower alkenyl, optionally substituted aryl or heterocyclic, or a group of the formula (ii): wherein X is oxygen or sulfur, R 8 is hydrogen or lower alkyl, R 9 is hydrogen, optionally substituted lower alkyl, cyclo(lower)alkyl, lower alkoxy or mono- or di-lower alkylamino or R 8 and R 9 may combine together to form optionally substituted saturated N-containing heterocyclic, or a salt thereof.

  一种公式为(I)的噻唑衍生物，其中R是1-可选取代的6-氧代-1,6-二氢-3-吡啶基，R'是可选取代的苯基，而R2是氢，公式(i)的基团：其中R4是氢、较低的烷基或较低的烯基，而R5是氢、可选取代的较低烷基、酰基、环(较低)烷基、较低烯基、可选取代的芳基或杂环基，或公式(ii)的基团：其中X是氧或硫，R8是氢或较低的烷基，R9是氢、可选取代的较低烷基、环(较低)烷基、较低烷氧基或单-或双-较低烷基氨基，或R8和R9可以结合形成可选取代的饱和含氮杂环，或其盐。
• THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1441732A2

  公开（公告）日：2004-08-04
• [EN] THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF<br/>[FR] DERIVE DE THIAZOLE ET UTILISATION PHARMACEUTIQUE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2003039451A2

  公开（公告）日：2003-05-15

  A thiazole derivative of the formula (I):wherein R is 1-optiona lly substituted-6-oxo-1,6-dihydro-3-pyridazinyl, R' is an optionally substituted phenyl, and R2 is hydrogen, a group of the formula (i): wherein R4 is hydrogen, lower alkyl or lower alkenyl, and R5 is hydrogen, optionally substituted lower alkyl, acyl, cyclo(lower)alkyl, lower alkenyl, optionally substituted aryl or heterocyclic, or a group of the formula (ii): wherein X is oxygen or sulfur, R8 is hydrogen or lower alkyl, R9 is hydrogen, optionally substituted lower alkyl, cyclo(lower)alkyl, lower alkoxy or mono- or di-lower alkylamino or R?8 and R9¿ may be combine together to form optionally substituted saturated N-containing heterocyclic, or a salt thereof._The compounds are useful as Adenosine antagonists. The application also discloses an improved process for the preparation of pyridazinones (XII-1)
• The Chemistry of Maleic Hydrazide. II.¹ The Course of the Michael-type Addition²
  作者：Henry Feuer、Ronald Harmetz

  DOI：10.1021/ja01554a075

  日期：1958.11