N'-(5-chloro-2-oxoindol-3-yl)-4-fluorobenzohydrazide | 84919-27-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N'-(5-chloro-2-oxoindol-3-yl)-4-fluorobenzohydrazide
• CAS: 84919-27-7
• 化学式: C₁₅H₉ClFN₃O₂
• 分子量: 317.707
• InChiKey: MKICEKRAOCGXBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.57
• 重原子数：
  22.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.56
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  哌啶 、 聚合甲醛 、 N'-(5-chloro-2-oxoindol-3-yl)-4-fluorobenzohydrazide 以 乙醇 为溶剂， 以62%的产率得到
  参考文献：
  名称：

  Varma; Pandey, Journal of the Indian Chemical Society, 1982, vol. 59, # 10, p. 1174 - 1176

  摘要：

  DOI：
• 作为产物：
  描述：

  6-Chloro-1,4-dihydroquinoline-2,3-dione 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 11.0h， 生成 N'-(5-chloro-2-oxoindol-3-yl)-4-fluorobenzohydrazide
  参考文献：
  名称：

  Varma; Pandey, Journal of the Indian Chemical Society, 1982, vol. 59, # 10, p. 1174 - 1176

  摘要：

  DOI：

文献信息

• Identification and synthesis of N′-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase
  作者：Zhongjie Liang、Dengyou Zhang、Jing Ai、Limin Chen、Hengshuai Wang、Xiangqian Kong、Mingyue Zheng、Hong Liu、Cheng Luo、Meiyu Geng、Hualiang Jiang、Kaixian Chen

  DOI：10.1016/j.bmcl.2011.04.064

  日期：2011.6

  A series of N'-(2-oxoindolin-3-ylidene)hydrazide derivatives were identified as moderately potent inhibitors against c-Met kinase by pharmacophore-based virtual screening and chemical synthesis methods. The structure-activity relationship (SAR) at various positions of the scaffold was investigated and its binding mode with c-Met kinase was analyzed by molecular modeling studies. In this study, two potent compounds D2 and D25, with IC50 value at 1.3 mu M and 2.2 mu M against c-Met kinase respectively, were identified. Finally, based on the clues extracted from this study, future development for the optimization of this scaffold was discussed. (C) 2011 Elsevier Ltd. All rights reserved.
• VARMA, RAJENDRA, S.;PANDEY, RAJNISH, K., J. INDIAN CHEM. SOC., 1982, 59, N 10, 1174-1176
  作者：VARMA, RAJENDRA, S.、PANDEY, RAJNISH, K.

  DOI：——

  日期：——
• Varma; Pandey, Journal of the Indian Chemical Society, 1982, vol. 59, # 10, p. 1174 - 1176
  作者：Varma、Pandey

  DOI：——

  日期：——