2-丁基-6-甲氧基萘 | 701270-26-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2-丁基-6-甲氧基萘
• 中文别名: 2-丁基-6-甲氧基-萘
• 英文名称: 2-butyl-6-methoxynaphthalene
• CAS: 701270-26-0
• 化学式: C₁₅H₁₈O
• 分子量: 214.307
• InChiKey: BJLRUUACNLOUQG-UHFFFAOYSA-N

物化性质

• 熔点：
  62-65°C
• 沸点：
  332.6±11.0 °C(Predicted)
• 密度：
  1.004±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿、乙酸乙酯

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-丁基-6-甲氧基萘 在 copper(l) iodide 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 硫酸 、 双氧水 、 三溴化硼 、 sodium hydride 、 sodium carbonate 、 potassium iodide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 、 mineral oil 为溶剂， 反应 93.5h， 生成
  参考文献：
  名称：

  可嵌套的Tetrakis（spiroborate）纳米周期

  摘要：

  通过使双（二羟基萘）与四羟基蒽醌在硼酸存在下以自组织方式反应，实现了四（螺硼酸酯）阴离子纳米环的多组分构建。这些纳米环表现出对阳离子客体如甲基紫精衍生物的选择性分子识别行为。通过结合阴离子纳米环和环双（百草枯-对苯撑）的乙烯基类似物，观察到超分子[受电子邮件保护]和[受电子邮件保护]环结构的形成。

  DOI：

  10.1021/acs.orglett.5b00747
• 作为产物：
  描述：

  1-(6-methoxynaphth-2-yl)butan-1-one 在 氢氧化钾 、 一水合肼 作用下， 以 乙二醇 为溶剂， 生成 2-丁基-6-甲氧基萘
  参考文献：
  名称：

  Synthesis and Characterization of Liquid Crystalline Semiconducting Materials, Dialkyl-2-phenylnaphthalene Derivatives—Mesomorphic behavior and Charge carrier transport

  摘要：

  For establishment of high electronic charge carrier transport at ambient temperature, dialkyl derivatives of 2-phenylnaphthalene have been synthesized and characterized their liquid crystalline behaviors and photoelectrical properties. These materials exhibited smectic mesophases (Smectic A, B and E phases), at fairly low temperature range extended down below ambient temperature. Fast electronic transport of positive carriers was observed in SmE phase of 2-(4'-octylphenyl)-6-butylnaphthalene at 30degreesC, whose mobility was over 10(-2) cm(2)/Vs.

  DOI：

  10.1080/15421400490435251

文献信息

• Suzuki-Miyaura and Related Cross-Couplings in Aqueous Solvents Catalyzed by Di(2-pyridyl)methylamine-Palladium Dichloride Complexes
  作者：Carmen Nájera、Juan Gil-Moltó、Sofia Karlström

  DOI：10.1002/adsc.200404195

  日期：2004.12

  dichloride complexes 4 are versatile catalysts for different types of cross-coupling reactions in water or aqueous solvents under aerobic conditions. The Suzuki–Miyaura reaction of arylboronic acids can be performed with bromoarenes under water reflux using K2CO3 as base or at room temperature or 60 °C in aqueous methanol using KOH as base. For aryl chlorides the corresponding cross-couplings with arylboronic

  基于二（2-吡啶基）甲胺的二氯化钯配合物4是通用的催化剂，用于在好氧条件下在水或水性溶剂中进行不同类型的交叉偶联反应。芳基硼酸的Suzuki-Miyaura反应可以与溴代芳烃在回流下，以K 2 CO 3为碱，或在室温或60°C的甲醇水溶液中，以KOH为碱，进行。对于芳基氯化物，相应的与芳基硼酸的交叉偶联可以在回流水中与K 2 CO 3进行。作为碱，以TBAB为添加剂，以提供联芳基和杂联芳基。芳基硼酸还在以K 2 CO 3为碱或在室温下在丙酮水溶液和KOH为碱的回流水中与苄基氯和烯丙基底物如氯化物，乙酸盐或碳酸盐反应，得到二芳基甲烷和芳基丙烯。三甲基环硼氧烷和烷基硼酸在水中与K 2 CO 3回流下与溴代和氯代芳烃偶联作为基础，TBAB作为添加剂，提供甲基和丁基芳烃。这些交叉耦合也已经在微波辐射下在较短的时间内完成了。几种重要的中间体，例如4'-甲基联苯-2-腈，4-联苯乙酸，3-（3-甲基苯基）苯甲酸，4
• Heterogeneous Nickel‐Catalyzed Cross‐Coupling between Aryl Chlorides and Alkyllithiums Using a Polystyrene‐Cross‐Linking Bisphosphine Ligand
  作者：Yuki Yamazaki、Nozomi Arima、Tomohiro Iwai、Masaya Sawamura

  DOI：10.1002/adsc.201801713

  日期：2019.5.14

  A polystyrene‐cross‐linking bisphosphine ligand PS‐DPPBz was used for Ni‐catalyzed cross‐coupling with organolithiums. A bench‐stable precatalyst [NiCl2(PS‐DPPBz)] enabled efficient coupling reactions between aryl chlorides and alkyllithiums. The heterogeneous Ni system showed good reusability.

  聚苯乙烯交联双膦配体PS-DPPBz用于Ni催化与有机锂的交叉偶联。稳定的前催化剂[NiCl 2（PS-DPPBz）]使芳基氯化物与烷基锂之间的有效偶联反应成为可能。Ni的异质体系显示出良好的可重用性。
• Nickel(0)-Catalyzed Inert C–O Bond Functionalization: Organo Rare-Earth Metal Complex as the Coupling Partner
  作者：Xiangqian Yan、Fanzhi Yang、Guilong Cai、Qingwei Meng、Xiaofang Li

  DOI：10.1021/acs.orglett.7b03753

  日期：2018.2.2

  An organo rare-earth metal complex has been employed as a highly efficient nucleophile in Ni(0)-catalyzed C–O bond functionalization. The optimized catalytic system which consists of Ni(cod)2, PCy3, and t-BuONa could smoothly convert 1 equiv of naphthyl ethers to alkylated naphthalene analogues with 0.4 equiv of Ln(CH2SiMe3)3(THF)2, delivering good to excellent yields. The reaction system could also

  有机稀土金属配合物已被用作Ni（0）催化的C-O键功能化中的高效亲核试剂。由Ni（cod）2，PCy 3和t- BuONa组成的优化催化体系可将0.4当量的Ln（CH 2 SiMe 3）3（THF）2平稳地转化为1当量的萘醚为烷基化萘类似物，好到极好的产量。该反应系统还可以用弱碱激活ArCH 2 -O键。
• Delivery system and methods for protecting and administering dextroamphetamine
  申请人：Shire LLC

  公开号：EP2316469A1

  公开（公告）日：2011-05-04

  The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions.

  本发明涉及活性剂给药系统，更具体地说，涉及由与活性剂共价连接的氨基酸（作为单个氨基酸或肽）组成的组合物以及给药共轭活性剂组合物的方法。
• Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates
  作者：Toolika Agrawal、Silas P. Cook

  DOI：10.1021/ol303130j

  日期：2013.1.4

  The iron-catalyzed cross-coupling of aryl sulfamates and tosylates has been achieved with primary and secondary alkyl Grignards. This study of iron-catalyzed cross-coupling reactions also examines the isomerization and beta-hydride elimination problems that are associated with the use of isopropyl nucleophiles. While a variety of iron sources were competent in the reaction, the use of FeF3 center dot 3H(2)O was critical to minimize nucleophile isomerization.