2-丁基硫烷基-6-氯吡啶 | 87512-14-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 2-丁基硫烷基-6-氯吡啶
• 英文名称: 2-n-butylsulphenyl-6-chloropyridine
• 英文别名: 2-(butylthio)-6-chloropyridine；2-(Butylsulfanyl)-6-chloropyridine；2-butylsulfanyl-6-chloropyridine
• CAS: 87512-14-9
• 化学式: C₉H₁₂ClNS
• 分子量: 201.72
• InChiKey: LQQZRDBICKDNKT-UHFFFAOYSA-N

物化性质

• 沸点：
  294.1±25.0 °C(Predicted)
• 密度：
  1.15±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  哌嗪 、 2-丁基硫烷基-6-氯吡啶 以 正丁醇 为溶剂， 反应 8.0h， 以50%的产率得到1-(6-butylthio-2-pyridinyl)piperazine
  参考文献：
  名称：

  6-Alkyl-N,N-disubstituted-2-pyridinamines as anticonvulsant agents

  摘要：

  The anticonvulsant effect of a series of 6-alkyl-N,N-disubstituted-2-pyridinamines is described. An investigation was carried out to optimize the anticonvulsant activity and reduce behavioral side effects in this series. Three compounds (7, 8, 10; Table I) were selected from initial screening for a more complete pharmacological evaluation. While each of these compounds was a potent anticonvulsant agent with ED50 values from 5 to 10 mg/kg, the activity was accompanied by significant behavioral side effects including decreased spontaneous locomotion, ataxia, and ptosis.

  DOI：

  10.1021/jm00126a015
• 作为产物：
  描述：

  2,6-二氯吡啶 、 丁硫醇 在 sodium 作用下， 生成 2-丁基硫烷基-6-氯吡啶
  参考文献：
  名称：

  6-Alkyl-N,N-disubstituted-2-pyridinamines as anticonvulsant agents

  摘要：

  The anticonvulsant effect of a series of 6-alkyl-N,N-disubstituted-2-pyridinamines is described. An investigation was carried out to optimize the anticonvulsant activity and reduce behavioral side effects in this series. Three compounds (7, 8, 10; Table I) were selected from initial screening for a more complete pharmacological evaluation. While each of these compounds was a potent anticonvulsant agent with ED50 values from 5 to 10 mg/kg, the activity was accompanied by significant behavioral side effects including decreased spontaneous locomotion, ataxia, and ptosis.

  DOI：

  10.1021/jm00126a015

文献信息

• Selective ipso-substitution in pyridine ring and its application for the synthesis of macrocylces containing both oxa- and thia-bridges
  作者：Naomichi Furukawa、Satoshi Ogawa、Tsutomu Kawai、Shigeru Oae

  DOI：10.1016/s0040-4039(00)88146-0

  日期：1983.1
• Furukawa, Naomichi; Ogawa, Satoshi; Kawai, Tsutomu, Journal of the Chemical Society. Perkin transactions I, 1984, # 8, p. 1839 - 1845
  作者：Furukawa, Naomichi、Ogawa, Satoshi、Kawai, Tsutomu、Oae, Shigeru

  DOI：——

  日期：——
• PAVIA, MICHAEL R.;TAYLOR, CHARLES P.;LOBBESTAEL, SANDRA J., J. MED. CHEM., 32,(1989) N, C. 1237-1242
  作者：PAVIA, MICHAEL R.、TAYLOR, CHARLES P.、LOBBESTAEL, SANDRA J.

  DOI：——

  日期：——
• FURUKAWA, NAOMICHI;OGAWA, SATOSHI;KAWAI, TSUTOMU;OAE, SHIGERU, TETRAHEDRON LETT., 1983, 24, N 31, 3243-3246
  作者：FURUKAWA, NAOMICHI、OGAWA, SATOSHI、KAWAI, TSUTOMU、OAE, SHIGERU

  DOI：——

  日期：——
• FURUKAWA, NAOMICHI;OGAWA, SATOSHI;KAWAI, TSUTOMU;OAE, SHIGERU, J. CHEM. SOC. PERKIN TRANS., 1984, N 8, 1839-1845
  作者：FURUKAWA, NAOMICHI、OGAWA, SATOSHI、KAWAI, TSUTOMU、OAE, SHIGERU

  DOI：——

  日期：——