(4-amino-butyl)-(5-amino-pentyl)-amine | 62572-78-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (4-amino-butyl)-(5-amino-pentyl)-amine
• 英文别名: (4-Amino-butyl)-(5-amino-pentyl)-amin；N-(4-aminobutyl)cadaverine；1,5-Pentanediamine, N-(4-aminobutyl)-；N'-(4-aminobutyl)pentane-1,5-diamine
• CAS: 62572-78-5
• 化学式: C₉H₂₃N₃
• 分子量: 173.302
• InChiKey: XHRDTOGCOTXOLX-UHFFFAOYSA-N

物化性质

• 熔点：
  40 °C
• 沸点：
  165-166 °C(Press: 14 Torr)
• 密度：
  0.896±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-溴戊腈 在 Raney nickel W-2 ammonium hydroxide 、 氢溴酸 、 氢气 、 sodium hydride 、 苯酚 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 溶剂黄146 为溶剂， 25.0 ℃ 、379.21 kPa 条件下， 反应 44.5h， 生成 (4-amino-butyl)-(5-amino-pentyl)-amine
  参考文献：
  名称：

  A Comparison of Structure−Activity Relationships between Spermidine and Spermine Analogue Antineoplastics

  摘要：

  A systematic investigation of the impact of spermidine analogues both in vitro and in vivo is described. The study characterizes the effects of these analogues on L1210 cell growth, polyamine pools, ornithine decarboxylase, S-adenosyl-L-methionine decarboxylase, spermidine/spermine N-1-acetyltransferase, the maintenance of cellular charge, i.e., cationic equivalence associated with the polyamines and their analogues, and compares their ability to compete with spermidine for transport. The findings clearly demonstrate that the activity of-the linear polyamine analogues is highly dependent on the length of the triamines and the size of the N-alpha,N-omega-substituents. It appears that there is an optimum chain length for various activities and that the larger the N-alpha,N-omega-alkyls, the less active the compound. Metabolic transformation including N-dealkylation of these compounds is also evaluated. While there is no monotonic relationship between chain length and the ability of the analogue to be metabolized, the dipropyl triamines are clearly more actively catabolized than the corresponding methyl and ethyl systems. A comparison of the triamines with the corresponding tetraamines is made throughout the text regarding both in vitro activity against L1210 cells and in vivo toxicity measurements, suggesting that several triamine analogues may offer therapeutic advantages over the corresponding tetraamines.

  DOI：

  10.1021/jm960849j

文献信息

• Salts of triazinic compounds with phosphorus oxyacids, and use of said compounds in self-extinguishing polymeric compositions
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0537837A1

  公开（公告）日：1993-04-21

  Salts of triazinic compounds with phosphorus oxyacids, having the general formula (I): obtained by salifying oligomeric derivatives of 2,4, 6-triamino-1,3,5-triazine with a phosphorus-containing acid. The compounds with general formula (I) find use in particular as flame-retardant additives.

  三嗪化合物与含磷氧酸盐的盐，其一般式为(I)：通过用含磷酸盐对2,4,6-三氨基-1,3,5-三嗪的寡聚衍生物进行盐化而获得。具有一般式(I)的化合物特别用作阻燃添加剂。
• Self-extinguishing polymeric compositions
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0415371A2

  公开（公告）日：1991-03-06

  Described are self-extinguishing polymeric compositions comprising: (a) from 89 to 45 parts by weight of thermoplastic polymer, or of polymer endowed with elastomeric properties; b) from 8 to 30 parts by weight of one or more ammonium and/or amine phosphate(s) and/or phosphonate(s); (c) from 3 to 25 parts by weight of one or more 2,4,6-triamino-1,3,5-triazine derivatives of general formula (I): wherein the groups R to R₄, Z, Z₁ and Z₂ and the subscripts a and b are as defined in claim 1.

  所述自熄灭聚合物组合物包括 (a) 89 至 45 份（按重量计）热塑性聚合物或具有弹性特性的聚合物； b) 8 至 30 份（按重量计）一种或多种磷酸铵和/或胺和/或膦酸盐； (c) 一种或多种通式(I)的 2,4,6-三氨基-1,3,5-三嗪衍生物，按重量计，3 至 25 份： 其中基团 R 至 R₄、Z、Z₁ 和 Z₂ 以及下标 a 和 b 如权利要求 1 所定义。
• Triazinic compounds
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0448774A2

  公开（公告）日：1991-10-02

  Disclosed are triazinic compounds of general formula (I): wherein the various groups R and Z and the subscripts are as defined in claim 1. The compounds of general formula (I) are particularly useful as flame-retardant additives for polymers.

  所公开的是通式（I）的三嗪类化合物： 其中各基团 R 和 Z 以及下标如权利要求 1 所定义。 通式（I）化合物特别适用于聚合物的阻燃添加剂。
• Diamino-s-triazinon derivatives and self-extinguishing polymeric compositions containing them
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0475367A1

  公开（公告）日：1992-03-18

  Disclosed are ameline derivatives of general formula (I): as defined in claim 1 and the use thereof as flame-proofing agents in self-extinguishing polymeric compositions.

  所公开的是通式（I）的酰胺啉衍生物： 及其在自熄性聚合物组合物中作为阻燃剂的用途。
• Ammonium polyphosphate microencapsulated with aminoplastic resins
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0542373A1

  公开（公告）日：1993-05-19

  Ammonium polyphosphate having the general formula (I):         (NH₄)n+2PnO3n+1   (I) microencapsulated with condensation compounds obtained by means of the polymerization of polyaminic compositions essentially constituted by derivatives of 2,4,6-triamino-1,3,5-triazine, having the general formula (II): with aldehydes, preferably formaldehyde.

  具有通式 (I) 的聚磷酸铵： (NH₄)n+2PnO3n+1 (I) 微胶囊中含有通过聚合基本上由 2,4,6-三氨基-1,3,5-三嗪的衍生物构成的多氨基组合物而获得的缩合化合物，其通式为 (II)： 与醛（最好是甲醛）聚合而成。