3-(1,1,2-trifluoro-2-chloroethoxy)phenol | 88553-87-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(1,1,2-trifluoro-2-chloroethoxy)phenol
• 英文别名: 3-(2-Chloro-1,1,2-trifluoroethoxy)phenol
• CAS: 88553-87-1
• 化学式: C₈H₆ClF₃O₂
• 分子量: 226.583
• InChiKey: SRVSKVOOJCSTRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  氯乙酸 、 3-(1,1,2-trifluoro-2-chloroethoxy)phenol 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 4.0h， 以82%的产率得到3-(1,1,2-trifluoro-2-chloroethoxy)phenoxyacetic acid
  参考文献：
  名称：

  Phenols Reactions with 1,1-Difluorodichloroethene, 1,2-Di(fluorochloro)ethene, and Trifluorochloroethene

  摘要：

  Phenols containing in the para-position of the benzene ring substituents of various electronic character add to 1,1-ditluorodichloroethene in acetone in the presence of potassium hydroxide. A similar reaction with 1,2-di(fluorochloro)ethene occurs only in DMF or N,N-dimethylacetamide and is followed by hydrogen chloride elimination. Phenols with electron-donor substituents add to trifluorochloroethene in acetone in the presence of potassium hydroxide, the reaction of phenols with electron-acceptor substituents requires DMF as solvent.

  DOI：

  10.1023/b:rujo.0000010179.88527.27
• 作为产物：
  描述：

  3-(1,1,2-trifluoro-2-chloroethoxy)aniline 在 硫酸 、 sodium nitrite 、 copper(II) sulfate 作用下， 以 水 为溶剂， 生成 3-(1,1,2-trifluoro-2-chloroethoxy)phenol
  参考文献：
  名称：

  Phenols Reactions with 1,1-Difluorodichloroethene, 1,2-Di(fluorochloro)ethene, and Trifluorochloroethene

  摘要：

  Phenols containing in the para-position of the benzene ring substituents of various electronic character add to 1,1-ditluorodichloroethene in acetone in the presence of potassium hydroxide. A similar reaction with 1,2-di(fluorochloro)ethene occurs only in DMF or N,N-dimethylacetamide and is followed by hydrogen chloride elimination. Phenols with electron-donor substituents add to trifluorochloroethene in acetone in the presence of potassium hydroxide, the reaction of phenols with electron-acceptor substituents requires DMF as solvent.

  DOI：

  10.1023/b:rujo.0000010179.88527.27

文献信息

• SEUFERT, W.;VARWIG, J.;HUSSLEIN, G.;SEPPELT, W.;ADOLPHI, H.
  作者：SEUFERT, W.、VARWIG, J.、HUSSLEIN, G.、SEPPELT, W.、ADOLPHI, H.

  DOI：——

  日期：——
• Phenols Reactions with 1,1-Difluorodichloroethene, 1,2-Di(fluorochloro)ethene, and Trifluorochloroethene
  作者：M. M. Kremlev、A. I. Mushta、L. I. Moklyarchuk

  DOI：10.1023/b:rujo.0000010179.88527.27

  日期：2003.8

  Phenols containing in the para-position of the benzene ring substituents of various electronic character add to 1,1-ditluorodichloroethene in acetone in the presence of potassium hydroxide. A similar reaction with 1,2-di(fluorochloro)ethene occurs only in DMF or N,N-dimethylacetamide and is followed by hydrogen chloride elimination. Phenols with electron-donor substituents add to trifluorochloroethene in acetone in the presence of potassium hydroxide, the reaction of phenols with electron-acceptor substituents requires DMF as solvent.