4-bromo-4'-n-heptyloxybiphenyl | 63619-65-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-bromo-4'-n-heptyloxybiphenyl
• 英文别名: 4-bromo-4'-heptyloxybiphenyl；1-bromo-4-(4-heptoxyphenyl)benzene
• CAS: 63619-65-8
• 化学式: C₁₉H₂₃BrO
• 分子量: 347.295
• InChiKey: RPKKVGYCNBDCKG-UHFFFAOYSA-N

物化性质

• 沸点：
  427.9±28.0 °C(Predicted)
• 密度：
  1.181±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-bromo-4'-n-heptyloxybiphenyl 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 以42%的产率得到4'-heptoxybiphenyl-4-carbaldehyde
  参考文献：
  名称：

  Cyclic compounds

  摘要：

  本发明涉及由公式（I）表示的新型Aerothricins，其中R1、R2、R3、R4、R5、X、Y、Z和m如权利要求书1所定义的；以及其药学上可接受的盐。本发明还涉及包含公式（I）的Aerothricin和药学上可接受的载体的制药组合物。此外，本发明还涉及使用这些Aerothricins制备药物的用途，以及制备公式（I）的Aerothricins的过程和中间体。

  公开号：

  US06489440B1
• 作为产物：
  描述：

  4-乙酰氧基-4'-溴代联苯 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 6.0h， 生成 4-bromo-4'-n-heptyloxybiphenyl
  参考文献：
  名称：

  The Synthesis and Property of Liquid Crystalline 4-Alkoxyl-4″-Cyano-p-Terphenyls

  摘要：

  The synthesis of some new 4-alkoxyl-4 "-cyano-p-terphenyls is described. The preliminary characterization by means of polarized optical microscopy, differential scanning calorimetry and X-ray diffraction shows that all these compounds are thermotropically liquid-crystalline and can form both the nematic and smectic mesophases.

  DOI：

  10.1080/10587250008031039

文献信息

• Lipopeptide Compounds and Their Use
  申请人：Boyce Rustum S.

  公开号：US20110224129A1

  公开（公告）日：2011-09-15

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain lipopeptide compounds comprising a cyclic peptide bearing a lipid side chain (for convenience, collectively referred to herein as “LP compounds”), which, inter alia, are antimicrobial, particularly antibacterial. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to provide an antimicrobial function, particularly an antibacterial function, and in the treatment of diseases and conditions that are mediated by microbes, particularly bacteria, that are ameliorated by the antimicrobial function, particularly an antibacterial function, including bacterial diseases, optionally in combination with another agent, for example, another antibacterial agent.

  本发明一般涉及治疗化合物领域，更具体地涉及包括带有脂肪侧链的环肽的某些脂肽化合物（为方便起见，在本文中统称为“LP化合物”），其中，这些化合物具有抗微生物作用，特别是抗菌作用。本发明还涉及包括这些化合物的药物组合物，以及使用这些化合物和组合物，在体外和体内提供抗微生物功能，特别是抗菌功能，以及在治疗由微生物介导的疾病和病症方面的用途，特别是由抗菌功能缓解的细菌疾病，可选地与另一药剂（例如另一抗菌剂）结合使用。
• Synthesis of Liquid Crystal Molecules Based on Bis(biphenyl)diacetylene and Their Liquid Crystallinity
  作者：Makoto Uchimura、Sungmin Kang、Rohei Ishige、Junji Watanabe、Gen-ichi Konishi

  DOI：10.1246/cl.2010.513

  日期：2010.5.5

  We synthesized novel liquid crystalline molecules that contain a bis(biphenyl)diacetylene mesogen and confirmed their structures by 1H NMR, 13C NMR, and FT-IR spectroscopy and mass spectrometry. These compounds formed thermotropic liquid crystals in a wide temperature region that was well characterized by optical microscopic and X-ray measurements.

  我们合成了含有双（联苯）二炔介质的 novel 液晶分子，并通过 1H NMR、13C NMR、傅里叶变换红外光谱（FT-IR）和质谱确认了它们的结构。这些化合物在一个广泛的温度范围内形成了热致液晶，并通过光学显微镜和 X 射线测量进行了良好的表征。
• Intranasal cyclic peptide formulations
  申请人：——

  公开号：US20010038824A1

  公开（公告）日：2001-11-08

  The present invention relates to a nasally administrable composition of a physiologically active cyclic peptide and pharmaceutically acceptable salts thereof that is prepared by homogeneously dispersing a physiologically active cyclic peptide such as antifungal cyclic peptides (aerothricins, echinocandin analogs, pneumocandin analogs, and aureobacidines), antibacterial cyclic peptides (e.g. vancomycin, daptomycin), cyclosporin A, lanreotide, vapreotide, vasopressin antagonist (U.S. Pat. No. 5,095,003) and eptifibatide in unique carrier, i.e. a physiologically acceptable powdery or crystalline carrier containing a water insoluble polyvalent metal carrier, or organic carrier having a mean particle size of 20 to 500 &mgr;m, in the presence or absence of an absorption enhancer and by homogeneously adsorbing onto the carrier, and its use for therapeutic treatment of disease such as systemic fungal infections by intranasal administration. The composition can be nasally administered in powder form.

  本发明涉及一种鼻腔可给药的生理活性环肽及其药学上可接受的盐的组合物，该组合物通过将生理活性环肽（如抗真菌环肽（气菌素、伊曲康定类似物、肺孢子菌素类似物和金黄色细菌素）、抗菌环肽（如万古霉素、达托霉素）、环孢霉素A、兰雷罗肽、瓦普雷罗肽、抗利尿激素拮抗剂（美国专利号5,095,003）和依普利贝肽）均匀分散在独特的载体中制备而成，即含有水不溶性多价金属载体或平均粒径为20至500微米的有机载体的生理上可接受的粉状或结晶载体中，存在或不存在吸收增强剂，通过均匀吸附到载体上，并用于通过鼻内给药治疗疾病，如系统真菌感染。该组合物可以以粉剂形式鼻腔给药。
• An engineering plastic composition and an article made of the same
  申请人：SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0343606A1

  公开（公告）日：1989-11-29

  An engineering plastic composition with excellent flowability, heat stability, and desirable mechanical properties is provided. The composition comprises an engineering plastic material and at least one p-quaterphenyl derivative of specific formula.

  一种工程塑料组合物具有优异的流动性、热稳定性和理想的机械性能。该组合物由工程塑料材料和至少一种对四联苯衍生物组成。
• Total synthesis and structure–activity relationships of new echinocandin-like antifungal cyclolipohexapeptides
  作者：Jianzhong Yao、Hongming Liu、Ting Zhou、Hai Chen、Zhenyuan Miao、Chunquan Sheng、Wannian Zhang

  DOI：10.1016/j.ejmech.2012.01.054

  日期：2012.4

  A series of new echinocandin-like cyclolipohexapeptides were designed and total synthesized via solution phase [3 + 3]-segment coupling strategy with an attempt to improve antifungal activity. The designed compounds showed potent antifungal activities with broad spectrum. In particular, 11 compounds (i.e. 28a-e, 28g, 28i-j, 29a, 29c and 29e) showed better in vitro antifungal activities against Candida albicans or Aspergillus fumigatus than caspofungin. Moreover, the synthesized compounds provided new SAR information for the echinocandins. The findings in this work suggested that the "left" tripeptide segment of cyclolipohexapeptide scaffold might be a hydrophilic structural motif, whereas the "right" lipopeptide segment was preferred as a hydrophobic core. The amino acid component of the cyclolipohexapeptide scaffold could significantly affect the SAR of the side chains. (C) 2012 Elsevier Masson SAS. All rights reserved.