ethyl 2-hydroxyundecanoate | 94983-14-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 2-hydroxyundecanoate
• 英文别名: Ethyl-α-hydroxy-undecanoat；2-Hydroxy-undecansaeure-ethylester；α-Oxy-undecylsaeureethylester；2-hydroxy-undecanoic acid ethyl ester；α-Oxy-decan-α-carbonsaeure-aethylester；Undecanol-(2)-saeure-(1)-aethylester；2-Hydroxy-undecansaeure-aethylester
• CAS: 94983-14-9
• 化学式: C₁₃H₂₆O₃
• 分子量: 230.348
• InChiKey: QHKCPWIESMUWEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 2-hydroxyundecanoate 、 HEPTYLMAGNESIUM BROMIDE 生成 8-heptyl-octadecane-8,9-diol
  参考文献：
  名称：

  Lapkin,I.I. et al., Journal of Organic Chemistry USSR (English Translation), 1969, vol. 5, p. 868 - 870

  摘要：

  DOI：
• 作为产物：
  描述：

  2-chloro-2-(4-methylphenyl)sulfinyldodecan-3-ol 在 二甲基硫 、 臭氧 作用下， 以 xylene 为溶剂， 反应 0.33h， 生成 ethyl 2-hydroxyundecanoate
  参考文献：
  名称：

  1-Chloroalkyl p-tolyl sulfoxides as useful agents for homologation of carbonyl compounds: conversion of carbonyl compounds to .alpha.-hydroxy acids, esters, and amides and .alpha.,.alpha.'-dihydroxy ketones

  摘要：

  One-carbon homologation of carbonyl compounds to alpha-hydroxy acids, esters, and amides by the use of 1-chloroalkyl p-tolyl sulfoxide as a hydroxycarbonyl anion equivalent is reported. Oxidation of the vinyl chlorides, the intermediates of the above-mentioned method, with osmium tetraoxide gives alpha,alpha'-dihydroxy ketones which are found in biologically active natural products such as cortisone and adriamycin.

  DOI：

  10.1021/jo00013a011

文献信息

• POLYESTER POLYOL, COMPOSITION FOR POLYURETHANE, COMPOSITION FOR POLYURETHANE FOAM, POLYURETHANE RESIN, AND POLYURETHANE FOAM
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2308913A1

  公开（公告）日：2011-04-13

  The present invention provides a polyester polyol, preferably a plant-derived polyester polyol, suitable for a composition for polyurethane foam that contributes to the reduction of load on the environment and has a good balance of high resilience, moderate hardness, and high durability as a cushioning material for vehicle seat cushions. A polyester polyol having a hydroxyl value in the range of 15 to 100 mgKOH/g according to the present invention is produced by a condensation of raw materials comprising at least one selected from the group consisting of fatty acids having a hydroxy group and fatty acid esters having a hydroxy group with a polyhydric alcohol having an average number of functional groups of more than three but not more than eight. The raw materials contain 90% to 100% by mass of a fatty acid having a hydroxy group and a fatty acid ester having a hydroxy group in total.

  本发明提供了一种聚酯多元醇，最好是植物衍生的聚酯多元醇，适用于聚氨酯泡沫的组合物，有助于减少对环境的负荷，并在高回弹性、中等硬度和高耐用性之间取得良好平衡，可作为汽车坐垫的缓冲材料。根据本发明，羟基值在 15 至 100 mgKOH/g 范围内的聚酯多元醇是由至少一种选自具有羟基的脂肪酸和具有羟基的脂肪酸酯的原料与具有平均三个以上但不超过八个官能团的多元醇缩合而成。原料中具有羟基的脂肪酸和具有羟基的脂肪酸酯的总含量为 90%至 100%（以质量计）。
• Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof
  申请人：——

  公开号：US20030232091A1

  公开（公告）日：2003-12-18

  The present invention relates to a controlled release system useful to stabilize retinol, retinol derivatives, and extracts containing retinol in cosmetic, dermatological, and pharmaceutical compositions. More specifically, the present invention pertains to stabilized retinol in a solid hydrophobic particle that sustains the release of retinol during the product shelf life and enables a gradual and prolonged release of effective levels of retinol and other cosmetic, dermatological, and pharmaceutical active ingredients into biological surfaces. The present invention also refers to a process of stabilizing retinol, retinol derivatives, and extracts containing retinol in cosmetic, dermatological, and pharmaceutical compositions. The invention further relates to cosmetic, dermatological, and pharmaceutical products comprising stable retinol in a hydrophobic particle that can deliver effective levels of retinol and other cosmetic, dermatological, and pharmaceutical active ingredients to biological surfaces over an extended period of time.

  本发明涉及一种控释系统，用于稳定化妆品、皮肤病学和药物组合物中的视黄醇、视黄醇衍生物和含有视黄醇的提取物。更具体地说，本发明涉及在固体疏水性颗粒中稳定视黄醇，该颗粒可在产品保质期内维持视黄醇的释放，并使有效水平的视黄醇和其他化妆品、皮肤病学和药物活性成分逐渐并长时间地释放到生物表面。本发明还涉及一种稳定化妆品、皮肤病学和药物组合物中的视黄醇、视黄醇衍生物和含有视黄醇的提取物的工艺。本发明还涉及在疏水性颗粒中含有稳定视黄醇的化妆品、皮肤病学和药物产品，该疏水性颗粒可在较长时间内将有效水平的视黄醇和其他化妆品、皮肤病学和药物活性成分输送到生物表面。
• Multi component controlled delivery system for soap bars
  申请人：——

  公开号：US20030207776A1

  公开（公告）日：2003-11-06

  The present invention relates to an improved controlled delivery system that can be incorporated in soap bars to enhance deposition of active ingredients and sensory markers onto skin. The carrier system also provides controlled release or prolonged release of these actives from the skin over an extended period of time. The controlled delivery system of the present invention comprises substantially free-flowing, powder formed of solid hydrophobic, positively charged, nanospheres of encapsulated active ingredients, that are encapsulated in moisture sensitive microspheres. The high cationic charge density of the nanosphere improves deposition of active ingredients onto skin. The high cationic charge density on the nanosphere surface is created by incorporating a cationic conditioning agent into the solid hydrophobic matrix of the nanospheres, by incorporating a cationic charge “booster” in the moisture sensitive microsphere matrix, or by using a cationic conditioning agent in the nanosphere matrix in conjunction with a cationic charge “booster” in the microsphere matrix. The invention also pertains to soap products comprising the controlled release system of the present invention.

  本发明涉及一种改进的可控给药系统，可将其加入肥皂条中，以增强活性成分和感官标记在皮肤上的沉积。该载体系统还能使这些活性成分在较长时间内从皮肤中控制释放或延长释放时间。本发明的控释系统包括基本自由流动的粉末，由固态疏水性、带正电荷、封装活性成分的纳米球组成，这些纳米球封装在湿敏微球中。纳米球的高阳离子电荷密度提高了活性成分在皮肤上的沉积效果。纳米球表面的高阳离子电荷密度是通过在纳米球的固态疏水基质中加入阳离子调节剂，在湿敏微球基质中加入阳离子电荷 "增效剂"，或在纳米球基质中使用阳离子调节剂的同时在微球基质中使用阳离子电荷 "增效剂 "而产生的。本发明还涉及包含本发明控释系统的肥皂产品。
• Topical cosmetic compositions
  申请人：Gervasio-Nugent Carla

  公开号：US20050271692A1

  公开（公告）日：2005-12-08

  A topical cosmetic composition including: at least one water-soluble cosmetic agent; at least one oil-soluble cosmetic agent; and a dermal penetration enhancer, wherein topical application of the composition results in the delivery of the water-soluble and oil-soluble cosmetic agents into the stratum corneum as well as delivery of the oil-soluble cosmetic agent into the epidermis and dermis.

  一种局部化妆品组合物，包括：至少一种水溶性化妆品剂；至少一种油溶性化妆品剂；以及一种皮肤渗透促进剂，其中局部使用该组合物可将水溶性和油溶性化妆品剂输送到角质层，并将油溶性化妆品剂输送到表皮和真皮层。
• Skin care compositions including hexapeptide complexes and methods of their manufacture
  申请人：Dilallo Natalie

  公开号：US20060198800A1

  公开（公告）日：2006-09-07

  Skin care compositions disclosed herein include, at a minimum, safe and effective amounts of at least one wrinkle reduction agent, which is a hexapeptide, and a natural exfoliating complex. The skin care compositions provide natural skin exfoliation, reduce fine lines and wrinkles, and improve skin elasticity and firmness.

  本文公开的护肤组合物至少包括安全有效量的至少一种除皱剂（六胜肽）和天然去角质复合物。护肤组合物能天然去除皮肤角质，减少细纹和皱纹，改善皮肤弹性和紧致度。