2-(2-(2-hydroxyethoxy)ethylamino)-N-(2-chloroquinolin-8-yl)acetamide | 1161689-65-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-(2-hydroxyethoxy)ethylamino)-N-(2-chloroquinolin-8-yl)acetamide
• 英文别名: N-(2-chloroquinolin-8-yl)-2-[2-(2-hydroxyethoxy)ethylamino]acetamide
• CAS: 1161689-65-1
• 化学式: C₁₅H₁₈ClN₃O₃
• 分子量: 323.779
• InChiKey: XUCKTDPXGOZJJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  83.5
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氯喹啉-8-胺 在 吡啶 、 N,N-二异丙基乙胺 、 potassium iodide 作用下， 以 氯仿 、 乙腈 为溶剂， 反应 13.0h， 生成 2-(2-(2-hydroxyethoxy)ethylamino)-N-(2-chloroquinolin-8-yl)acetamide
  参考文献：
  名称：

  A new strategy for the ratiometric fluorescence detection of Zn(II) in the surfactant solution

  摘要：

  A new strategy derived from the intramolecular charge transfer mechanism was employed to create a ratiometric sensing system for Zn2+ in aqueous solution by using sodium dodecyl sulfate (SDS) micelles as the scaffold. The amphiphilic carboxamidoquinoline-based sensor (AQZ2Cl) was simultaneously solubilized at different locations in the SDS micelle. Some AQZ2Cl molecules were adsorbed at the micelle-water interface and emitted a fluorescence-enhancing and red-shifted signal upon binding Zn2+. And the others were incorporated into the palisade layer of the micelle, in which the produced bands had no appreciable changes with the addition of Zn2+, thus acting as an internal standard and allowing AQZ2Cl as a ratiometric sensor for the detection of Zn2+. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jphotochem.2013.02.001

文献信息

• A new strategy for the ratiometric fluorescence detection of Zn(II) in the surfactant solution
  作者：Yu Zhang、Xiangfeng Guo、Libo Zheng、Lihua Jia、Xuhong Qian

  DOI：10.1016/j.jphotochem.2013.02.001

  日期：2013.4

  A new strategy derived from the intramolecular charge transfer mechanism was employed to create a ratiometric sensing system for Zn2+ in aqueous solution by using sodium dodecyl sulfate (SDS) micelles as the scaffold. The amphiphilic carboxamidoquinoline-based sensor (AQZ2Cl) was simultaneously solubilized at different locations in the SDS micelle. Some AQZ2Cl molecules were adsorbed at the micelle-water interface and emitted a fluorescence-enhancing and red-shifted signal upon binding Zn2+. And the others were incorporated into the palisade layer of the micelle, in which the produced bands had no appreciable changes with the addition of Zn2+, thus acting as an internal standard and allowing AQZ2Cl as a ratiometric sensor for the detection of Zn2+. (C) 2013 Elsevier B.V. All rights reserved.