benzyl 4-methyl-2-trifluoromethylphenyl ether | 1204817-23-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl 4-methyl-2-trifluoromethylphenyl ether
• 英文别名: 4-Methyl-1-phenylmethoxy-2-(trifluoromethyl)benzene
• CAS: 1204817-23-1
• 化学式: C₁₅H₁₃F₃O
• 分子量: 266.263
• InChiKey: KNCFVPVXCQWMIM-UHFFFAOYSA-N

物化性质

• 沸点：
  324.3±42.0 °C(predicted)
• 密度：
  1.189±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  benzyl 4-methyl-2-trifluoromethylphenyl ether 在 palladium 10% on activated carbon 、 ammonium formate 作用下， 以 甲醇 为溶剂， 反应 1.5h， 生成 2-trifluoromethyl-4-methylphenol
  参考文献：
  名称：

  Syntheses and Bioactivity of o- or p-Trifluoromethylphenyl Phosphates

  摘要：

  o- and p-Trifluoromethylphenyl phosphates designed as mechanism-based phosphotyrosine phosphatase inactivators have been prepared. Some of them show herbicidal activities.

  DOI：

  10.1080/10426500802253090
• 作为产物：
  描述：

  氟磺酰基二氟乙酸甲酯 、 苄基-2-碘-4-甲基苯基醚 在 copper(l) iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以74%的产率得到benzyl 4-methyl-2-trifluoromethylphenyl ether
  参考文献：
  名称：

  Syntheses and Bioactivity of o- or p-Trifluoromethylphenyl Phosphates

  摘要：

  o- and p-Trifluoromethylphenyl phosphates designed as mechanism-based phosphotyrosine phosphatase inactivators have been prepared. Some of them show herbicidal activities.

  DOI：

  10.1080/10426500802253090

文献信息

• [EN] TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DU FACTEUR DE TRANSCRIPTION À DOMAINE ASSOCIÉ TRANSCRIPTIONNEL AMÉLIORÉ (TEAD) ET LEURS UTILISATIONS
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2020081572A1

  公开（公告）日：2020-04-23

  Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, compositions, and mixtures thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers, such as carcinoma, sarcoma, lung cancer, thyroid cancer, skin cancer, ovarian cancer, colorectal cancer, prostate cancer, pancreatic cancer, esophageal cancer, liver cancer, breast cancer)) in a subject. Provided are methods of inhibiting a TEAD transcription factors (e.g., TEAD1, TEAD2, TEAD3, TEAD4) in a subject.

  本文提供了式（I）的化合物，以及药用盐、溶剂合物、水合物、多晶型、共晶体、互变异构体、立体异构体、同位素标记衍生物、前药、组合物和混合物。还提供了涉及创新化合物或组合物的治疗和/或预防疾病（如增殖性疾病（如癌症，如癌症，肉瘤，肺癌，甲状腺癌，皮肤癌，卵巢癌，结直肠癌，前列腺癌，胰腺癌，食管癌，肝癌，乳腺癌））的方法和试剂盒。提供了在受试者中抑制TEAD转录因子（如TEAD1、TEAD2、TEAD3、TEAD4）的方法。
• Bisarylurea derivatives
  申请人：Buchstaller Hans-Peter

  公开号：US20070161677A1

  公开（公告）日：2007-07-12

  The present invention relates to bisarylurea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
• Syntheses and Bioactivity of <i>o</i>- or <i>p</i>-Trifluoromethylphenyl Phosphates
  作者：Xinming Zhou、Yantao He、Miao Wang、Yixiang Ding

  DOI：10.1080/10426500802253090

  日期：2009.3.10

  o- and p-Trifluoromethylphenyl phosphates designed as mechanism-based phosphotyrosine phosphatase inactivators have been prepared. Some of them show herbicidal activities.