4-(3,4-dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-benzoic acid | 63729-61-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3,4-dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-benzoic acid
• 英文别名: N-(p-carboxyphenyl)dimethylmaleimide；4-(3,4-dimethyl-2,5-dioxopyrrol-1-yl)benzoic acid
• CAS: 63729-61-3
• 化学式: C₁₃H₁₁NO₄
• mdl: MFCD03150658
• 分子量: 245.235
• InChiKey: ZOKADVKJAURKAZ-UHFFFAOYSA-N

物化性质

• 沸点：
  445.8±28.0 °C(Predicted)
• 密度：
  1.371±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.153
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,3-二甲基马来酸酐 、 对氨基苯甲酸 在 sodium acetate 、 乙酸酐 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 生成 4-(3,4-dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-benzoic acid
  参考文献：
  名称：

  LIQUID CRYSTAL THERMOSET MONOMER OR OLIGOMER, THERMOSETTING LIQUID CRYSTAL POLYMER COMPOSITION COMPRISING THE SAME AND PRINTED CIRCUIT BOARD USING THE SAME

  摘要：

  具有两端帽有马来酰亚胺的至少一个甲基基团的液晶热固性（LCT）单体或寡聚物，由式1表示： 其中R1和R2分别独立地为CH3或H，且R1和R2中至少有一个为甲基基团，Ar1为含有选择自酯、酰胺、酯酰胺、酯亚酰胺和醚亚酰胺单位的一种或多种结构单元的二价有机基团，Ar1的分子量不大于5000。

  公开号：

  US20090224203A1

文献信息

• Liquid crystal thermoset monomer or oligomer, thermosetting liquid crystal polymer composition comprising the same and printed circuit board using the same
  申请人：Samsung Electronics Co., Ltd.

  公开号：US07655155B2

  公开（公告）日：2010-02-02

  A liquid crystal thermoset (LCT) monomer or oligomer having both ends capped with maleimide having at least one methyl group, represented by Formula 1: wherein R1 and R2 are each independently CH3 or H, and at least one of R1 and R2 is a methyl group, and Ar1 is a divalent organic group containing one or more structural units selected from the group consisting of ester, amide, ester amide, ester imide and ether imide units, and Ar1 has a molecular weight not greater than 5,000.

  具有两端都帽有马来酰亚胺的液晶热固性（LCT）单体或寡聚体，至少有一个甲基基团，由式1表示：其中R1和R2各自独立地为CH3或H，且R1和R2中至少有一个为甲基基团，Ar1是含有一个或多个选自酯、酰胺、酯酰胺、酯亚胺和醚亚胺单元的二价有机基团，且Ar1的分子量不大于5,000。
• Articles from plasticized thermoplastic polyolefin compositions
  申请人：Tse Fu Mun

  公开号：US20060189744A1

  公开（公告）日：2006-08-24

  The present invention relates to articles made from plasticized thermoplastic polyolefin compositions comprising a thermoplastic polyolefin, a nucleating agent, and a non-functionalized hydrocarbon plasticizer.

  本发明涉及用塑化热塑性聚烯烃组合物制成的物品，该组合物包含热塑性聚烯烃、成核剂和非官能化烃增塑剂。
• Acute effects of alkylating agents on canine renal function: specifically designed synthetic maleimides
  作者：Daniel A. Koechel、Joan B. Tarloff、Gary O. Rankin

  DOI：10.1021/jm00355a017

  日期：1983.1

  Maleimidohippurates and maleimidobenzoates were synthesized that possess a carboxy group for active uptake into renal proximal tubular cells and a reactive maleimide moiety to covalently bond with proximal tubular components. The reactivity of the maleimide moiety in each series was progressively reduced by substitution of methyl groups in place of the vinyl hydrogens. In contrast to N-ethylmaleimide (NEM), the resulting maleimidohippurates and maleimidobenzoates did not possess significant diuretic activity in the dog following renal arterial administration. However, as predicted, the nephrotoxicity of the maleimidohippurates paralleled their in vitro alkylating ability and was quite specifically located in the proximal portion of the canine renal tubule.
• US4079041A
  申请人：——

  公开号：US4079041A

  公开（公告）日：1978-03-14
• US4163097A
  申请人：——

  公开号：US4163097A

  公开（公告）日：1979-07-31