2-丙基癸酸 | 123790-07-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-丙基癸酸
• 英文名称: 2-propyl decanoic acid
• 英文别名: α-propylcaprylic acid；2-propyldecanoic acid；2-propyl-decanoic acid；2-Propyl-decansaeure
• CAS: 123790-07-8；60948-96-1
• 化学式: C₁₃H₂₆O₂
• 分子量: 214.348
• InChiKey: SFQZYBRVKZYWDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 2-丙基癸酸 生成 Methyl-α-propyl-decanoat
  参考文献：
  名称：

  Manufacture of C13 higher fatty acids from their esters by carbonylation of dodecene-1 in ionic liquid medium

  摘要：

  The effect of catalyst nature, temperature, acidity, promoters, and feedstock composition on dodecene-1 carbonylation in the presence of Pd compounds in an ionic liquid medium yielding higher fatty acid and their esters was studied. Palladium salts without phosphine ligands show high activity in tetrabutylammonium bromide. In systems of this kind, the catalyst is suspended in the reaction mass in the form of Pd particles with a size of 4-10 nm. It was shown that the catalytic system can be repeatedly used without loss of activity. It is acceptable to use synthesis gas instead of bare carbon monoxide with the selectivity for tride-canoic acid increasing.

  DOI：

  10.1134/s096554411006006x
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 2-丙基癸酸
  参考文献：
  名称：

  Metzger; Gawalek, Journal fuer Praktische Chemie (Leipzig), 1955, vol. <4>2, p. 293,298

  摘要：

  DOI：

文献信息

• Ruthenium-catalysed hydroxycarbonylation of olefins
  作者：Ricarda Dühren、Peter Kucmierczyk、Ralf Jackstell、Robert Franke、Matthias Beller

  DOI：10.1039/d0cy02283g

  日期：——

  State-of-the-art catalyst systems for hydroxy- and alkoxycarbonylations of olefins make use of palladium complexes. In this work, we report a complementary ruthenium-catalysed hydroxycarbonylation of olefins applying an inexpensive Ru-precursor (Ru3(CO)12) and PCy3 as a ligand. Crucial for the success of this transformation is the use of hexafluoroisopropanol (HFIP) as the solvent in the presence of

  用于烯烃的羟基和烷氧基羰基化的最新催化剂体系利用钯配合物。在这项工作中，我们报告了使用便宜的Ru前体（Ru 3（CO）12）和PCy 3作为配体的互补钌催化的烯烃的羟基羰基化。该转化成功的关键是在酸性助催化剂（PTSA）存在下使用六氟异丙醇（HFIP）作为溶剂。总体而言，使用包括工业上相关的底物二异丁烯在内的脂族烯烃可获得中等至良好的收率。这种原子有效的催化转化可直接从未官能化的烯烃中获得各种羧酸。
• [EN] IRAK DEGRADERS AND USES THEREOF<br/>[FR] AGENTS DE DÉGRADATION D'IRAK ET LEURS UTILISATIONS
  申请人：KYMERA THERAPEUTICS INC

  公开号：WO2021127190A1

  公开（公告）日：2021-06-24

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用相同的方法。
• [EN] INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL<br/>[FR] INHIBITEURS DU CANAL POTASSIQUE MÉDULLAIRE EXTERNE RÉNAL
  申请人：MERCK SHARP & DOHME

  公开号：WO2016069428A1

  公开（公告）日：2016-05-06

  The present invention provides compounds of Formula I : (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

  本发明提供了化合物I的公式：（I）及其药用可接受的盐，这些化合物是ROMK（Kir1.1）通道的抑制剂。这些化合物可用作利尿剂和/或钠利尿剂，并用于治疗和预防包括高血压、心力衰竭和慢性肾脏疾病在内的心血管疾病以及与过多盐分和水分潴留相关的疾病。
• METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING PALLADIUM COMPOUND
  申请人：Komiyama Masato

  公开号：US20130158272A1

  公开（公告）日：2013-06-20

  The present invention provides a method for producing a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or intermediates of the same, said method being efficient and using a short process. The present invention is a novel coupling method for obtaining a compound represented by formula (3) by bringing about a coupling reaction between a compound represented by formula (1) and a compound represented by formula (2), in the presence of a palladium compound, a ligand capable of coordinating to the palladium compound, a base, a C 1 -C 40 carboxylic acid, and at least one kind of additive.

  本发明提供了一种生产黄嘌呤氧化酶抑制剂的方法，该抑制剂是治疗高尿酸血症的药物，或者其中间体，该方法高效且使用流程简短。本发明是一种新型耦合方法，通过在钯化合物、能够配位到钯化合物的配体、碱、C1-C40羧酸和至少一种添加剂的存在下，在式（1）所代表的化合物和式（2）所代表的化合物之间引发耦合反应，从而获得式（3）所代表的化合物。
• Fatty acids, soaps surfactant systems, and consumer products based thereon
  申请人：——

  公开号：US20040092418A1

  公开（公告）日：2004-05-13

  Novel fatty acids and derivatives thereof such as salts, new surfactant systems comprising one or more of these compounds, consumer products such as laundry products, personal care products, pharmaceutical compositions, industrial cleaners, and the like comprising said compounds or surfactant systems.

  小说脂肪酸及其衍生物，例如盐，新的表面活性剂系统包括其中一种或多种这些化合物，消费品，例如洗涤剂，个人护理产品，制药组成物，工业清洁剂等，包括所述化合物或表面活性剂系统。