1-(2-Methoxyphenyl)pentan-3-ol | 117941-94-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(2-Methoxyphenyl)pentan-3-ol
• CAS: 117941-94-3
• 化学式: C₁₂H₁₈O₂
• 分子量: 194.274
• InChiKey: UZSBWVROCSDNOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-Methoxyphenyl)pentan-3-ol 、 三羰基(萘)铬 生成 carbon monoxide;chromium;(3S)-1-(2-methoxyphenyl)pentan-3-ol
  参考文献：
  名称：

  UEMURA, MOTOKAZU;MINAMI, TATSUYA;HAYASHI, YUJI, J. AMER. CHEM. SOC., 109,(1987) N 17, 5277-5278

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(o-methoxyphenyl)pentan-3-one 在 sodium tetrahydroborate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 以98%的产率得到1-(2-Methoxyphenyl)pentan-3-ol
  参考文献：
  名称：

  Synthesis of yomogin using a telescoped α-methylene-γ-butyrolactone annelation procedure

  摘要：

  A novel and efficient synthetic route to the anti-cancer natural product yomogin has been developed using a Telescoped Intramolecular Michael-Olefination (TIMO) sequence as the key step. Two variants of the TIMO sequence have been used successfully: a two-step acylation approach using diethyl phosphonoacetic acid and a base-free variant using triphenylphosphoranylideneketene (Bestmann's ylide). The natural product, 3-oxodiplophyllin, was also prepared en route to yomogin. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.11.143

文献信息

• UEMURA, MOTOKAZU;MINAMI, TATSUYA;HAYASHI, YUJI, J. AMER. CHEM. SOC., 109,(1987) N 17, 5277-5278
  作者：UEMURA, MOTOKAZU、MINAMI, TATSUYA、HAYASHI, YUJI

  DOI：——

  日期：——
• Synthesis of yomogin using a telescoped α-methylene-γ-butyrolactone annelation procedure
  作者：Russell R.A. Kitson、Graeme D. McAllister、Richard J.K. Taylor

  DOI：10.1016/j.tetlet.2010.11.143

  日期：2011.2

  A novel and efficient synthetic route to the anti-cancer natural product yomogin has been developed using a Telescoped Intramolecular Michael-Olefination (TIMO) sequence as the key step. Two variants of the TIMO sequence have been used successfully: a two-step acylation approach using diethyl phosphonoacetic acid and a base-free variant using triphenylphosphoranylideneketene (Bestmann's ylide). The natural product, 3-oxodiplophyllin, was also prepared en route to yomogin. (C) 2010 Elsevier Ltd. All rights reserved.