C-[2-(5-Chloro-thiophen-2-yl)-1H-benzoimidazol-5-yl]-methylamine | 742073-15-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: C-[2-(5-Chloro-thiophen-2-yl)-1H-benzoimidazol-5-yl]-methylamine
• 英文别名: [2-(5-chlorothiophen-2-yl)-3H-benzimidazol-5-yl]methanamine
• CAS: 742073-15-0
• 化学式: C₁₂H₁₀ClN₃S
• mdl: MFCD23159022
• 分子量: 263.75
• InChiKey: JNGZHVNNSNJTNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  82.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-氧代-1-哌啶)-苯甲酸 、 C-[2-(5-Chloro-thiophen-2-yl)-1H-benzoimidazol-5-yl]-methylamine 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-[2-(5-Chloro-thiophen-2-yl)-1H-benzoimidazol-5-ylmethyl]-4-(2-oxo-piperidin-1-yl)-benzamide
  参考文献：
  名称：

  Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa

  摘要：

  Neutral weak halothiophene benzimidazole inhibitors of the serine protease factor Xa were identified via screening of a compound library. The X-ray crystal structure of representative 3a bound to human fXa confirmed the S1 binding mode. Starting from 3a a series of halothiophene benzimidazoles was synthesized and investigated for their factor Xa inhibitory activity. This led to potent and selective achiral inhibitors against fXa such as compounds 9k and 9w. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.097
• 作为产物：
  描述：

  3,4-二氨基苯甲腈 在 lithium aluminium tetrahydride 、 sodium hydrogensulfite 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 为溶剂， 反应 14.0h， 生成 C-[2-(5-Chloro-thiophen-2-yl)-1H-benzoimidazol-5-yl]-methylamine
  参考文献：
  名称：

  Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa

  摘要：

  Neutral weak halothiophene benzimidazole inhibitors of the serine protease factor Xa were identified via screening of a compound library. The X-ray crystal structure of representative 3a bound to human fXa confirmed the S1 binding mode. Starting from 3a a series of halothiophene benzimidazoles was synthesized and investigated for their factor Xa inhibitory activity. This led to potent and selective achiral inhibitors against fXa such as compounds 9k and 9w. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.097

文献信息

• BENZIMIDAZOLDERIVATE
  申请人：Merck Patent GmbH

  公开号：EP1558247B1

  公开（公告）日：2008-02-20
• US7566789B2
  申请人：——

  公开号：US7566789B2

  公开（公告）日：2009-07-28
• [DE] BENZIMIDAZOLDERIVATE<br/>[EN] BENZIMIDAZOLE DERIVATIVES<br/>[FR] DERIVES DE BENZIMIDAZOLE
  申请人：MERCK PATENT GMBH

  公开号：WO2004017963A1

  公开（公告）日：2004-03-04

  Neue verbindungen der formel I Wori D, X, X‘, W, Y, T und R1 die in patentanspruch 1 angegebene Bedeutung haben, Sind inhibitoren des koagulationsfaktors Xa und können zur Prophylaxe und/oder Terapie von thromboembolischen Erkrankungen und zur Behandlung von tumoren eingesetzt werden.
• Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa
  作者：Werner W.K.R Mederski、Dieter Dorsch、Soheila Anzali、Johannes Gleitz、Bertram Cezanne、Christos Tsaklakidis

  DOI：10.1016/j.bmcl.2004.04.097

  日期：2004.7

  Neutral weak halothiophene benzimidazole inhibitors of the serine protease factor Xa were identified via screening of a compound library. The X-ray crystal structure of representative 3a bound to human fXa confirmed the S1 binding mode. Starting from 3a a series of halothiophene benzimidazoles was synthesized and investigated for their factor Xa inhibitory activity. This led to potent and selective achiral inhibitors against fXa such as compounds 9k and 9w. (C) 2004 Elsevier Ltd. All rights reserved.