2-丙烯酸,2-甲基-,聚合乙烯基苯和1,2-丙二醇单(2-甲基-2-丙烯酸酯)

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 中文名称: 2-丙烯酸,2-甲基-,聚合乙烯基苯和1,2-丙二醇单(2-甲基-2-丙烯酸酯)
• 中文别名: O-[4-(3-硝基吡啶-2-基)二硫基丁基]羟胺盐酸盐
• 英文名称: hydron;O-[4-[(3-nitropyridin-2-yl)disulfanyl]butyl]hydroxylamine;chloride
• 化学式: C9H14ClN3O3S2
• 分子量: 311.8
• InChiKey: ZAWBYEZTDOXVRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.82
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  145
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Oxime conjugates and methods for their formation and use
  申请人：Papisov I Mikhail

  公开号：US20060058513A1

  公开（公告）日：2006-03-16

  The present invention relates to biodegradable biocompatible polyketals, methods for their preparation, and methods for creating animals by administration of biodegradable biocompatible polyketals. In one aspect, a method for forming the biodegradable biocompatible polyketals comprises combining a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate, which is combined with a reducing agent to form the biodegradable biocompatible polyketal. The resultant biodegradable biocompatible polyketals can be chemically modified to incorporate additional hydrophilic moieties. A method for treating animals includes the administration of the biodegradable biocompatible polyketal in which biologically active compounds or diagnostic labels can be disposed. The present invention also relates to chiral polyketals, methods for their preparation, and methods for use in chromatographic applications, specifically in chiral separations. A method for forming the chiral polyketals comprises combining a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate, which is combined with a suitable reagent to form the chiral polyketal. A method for use in chiral separations includes the incorporation of the chiral polyketals in the mobile phase during a chromatographic separation, or into chiral stationary phases such as gels. The present invention further relates to chiral polyketals as a source for chiral compounds, and methods for generating such chiral compounds.

  本发明涉及可生物降解、生物相容的聚酮醚，其制备方法以及通过给予可生物降解、生物相容的聚酮醚来创建动物的方法。在一个方面，制备可生物降解、生物相容的聚酮醚的方法包括将一种乙二醇特异性氧化剂与多糖结合以形成醛中间体，该中间体与还原剂结合以形成可生物降解、生物相容的聚酮醚。所得到的可生物降解、生物相容的聚酮醚可以进行化学修饰以纳入额外的亲水基团。治疗动物的方法包括给予可生物降解、生物相容的聚酮醚，其中可以分布生物活性化合物或诊断标记。本发明还涉及手性聚酮醚，其制备方法以及在色谱应用中使用的方法，特别是在手性分离中使用。制备手性聚酮醚的方法包括将一种乙二醇特异性氧化剂与多糖结合以形成醛中间体，该中间体与适当的试剂结合以形成手性聚酮醚。在手性分离中使用的方法包括将手性聚酮醚纳入色谱分离的流动相中，或纳入手性固定相中，例如凝胶中。本发明还涉及手性聚酮醚作为手性化合物的来源，以及生成这种手性化合物的方法。
• OXIME CONJUGATES AND METHODS FOR THEIR FORMATION AND USE
  申请人：Papisov Mikhail I.

  公开号：US20120027680A1

  公开（公告）日：2012-02-02

  The present invention relates to biodegradable biocompatible polyketals, methods for their preparation, and methods for treating animals by administration of biodegradable biocompatible polyketals. In one aspect, a method for forming the biodegradable biocompatible polyketals comprises combining a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate, which is combined with a reducing agent to form the biodegradable biocompatible polyketal. The resultant biodegradable biocompatible polyketals can be chemically modified to incorporate additional hydrophilic moieties. A method for treating animals includes the administration of the biodegradable biocompatible polyketal in which biologically active compounds or diagnostic labels can be disposed. The present invention also relates to chiral polyketals, methods for their preparation, and methods for use in chromatographic applications, specifically in chiral separations. A method for forming the chiral polyketals comprises combining a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate, which is combined with a suitable reagent to form the chiral polyketal. A method for use in chiral separations includes the incorporation of the chiral polyketals in the mobile phase during a chromatographic separation, or into chiral stationary phases such as gels. The present invention further relates to chiral polyketals as a source for chiral compounds, and methods for generating such chiral compounds.

  本发明涉及可生物降解、生物相容的聚酮醛类化合物、其制备方法以及通过给动物注射可生物降解、生物相容的聚酮醛类化合物进行治疗的方法。其中一种制备可生物降解、生物相容的聚酮醛类化合物的方法包括将一个对乙二醇特异性氧化剂与多糖结合以形成醛中间体，然后再将还原剂与醛中间体结合以形成可生物降解、生物相容的聚酮醛类化合物。得到的可生物降解、生物相容的聚酮醛类化合物可以进行化学修饰以加入额外的亲水基团。治疗动物的方法包括给动物注射可生物降解、生物相容的聚酮醛类化合物，其中可以放置生物活性化合物或诊断标记。本发明还涉及手性聚酮醛类化合物、其制备方法以及在色谱分离中的应用方法，特别是在手性分离中的应用方法。制备手性聚酮醛类化合物的方法包括将一个对乙二醇特异性氧化剂与多糖结合以形成醛中间体，然后再将合适的试剂与醛中间体结合以形成手性聚酮醛类化合物。在手性分离中的应用方法包括将手性聚酮醛类化合物纳入色谱分离的流动相中，或者将其纳入手性固定相中，例如凝胶中。本发明还涉及手性聚酮醛类化合物作为手性化合物的来源，以及产生此类手性化合物的方法。
• POLYACETAL DRUG CONJUGATES AS RELEASE SYSTEM
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：EP1667726A2

  公开（公告）日：2006-06-14
• Dual phase drug release system
  申请人：PAPISOV I. Mikhail

  公开号：US20070190018A1

  公开（公告）日：2007-08-16

  The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a modifier having a molecular weight≦10 kDa; denotes direct of indirect attachment of M to linker L M ; and each occurrence of L M is independently an optionally substituted succinamide-containing linker, whereby the modifier M is directly or indirectly attached to the succinamide linker through an amide bond, and the carrier is linked directly or indirectly to each occurrence of the succinamide linker through an ester bond. In another aspect, the invention provides compositions comprising the conjugates, methods for their preparation, and methods of use thereof in the treatment of various disorder, including, but not limited to cancer.
• DUAL PHASE DRUG RELEASE SYSTEM
  申请人：Papisov Mikhail I.

  公开号：US20110059010A1

  公开（公告）日：2011-03-10

  The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a modifier having a molecular weight ≦10 kDa; denotes direct of indirect attachment of M to linker L M ; and each occurrence of L M is independently an optionally substituted succinamide-containing linker, whereby the modifier M is directly or indirectly attached to the succinamide linker through an amide bond, and the carrier is linked directly or indirectly to each occurrence of the succinamide linker through an ester bond. In another aspect, the invention provides compositions comprising the conjugates, methods for their preparation, and methods of use thereof in the treatment of various disorder, including, but not limited to cancer.