2-[(2,6-Dichlorophenyl)amino]-5-hydroxy benzene acetic acid methyl ester | 1285680-62-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(2,6-Dichlorophenyl)amino]-5-hydroxy benzene acetic acid methyl ester
• 英文别名: methyl 2-[2-(2,6-dichloroanilino)-5-hydroxyphenyl]acetate
• CAS: 1285680-62-7
• 化学式: C₁₅H₁₃Cl₂NO₃
• 分子量: 326.179
• InChiKey: PNVDKEGULLHERA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[(2,6-Dichlorophenyl)amino]-5-hydroxy benzene acetic acid methyl ester 在 三苯基膦 、 sodium hydroxide 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 生成 2-(2,6-dichlorophenylamino)-5-(4-trifluoromethyl)benzyloxybenzenethanoic acid
  参考文献：
  名称：

  Diclofenac derivatives with insulin-sensitizing activity

  摘要：

  A series of diclofenac derivatives were synthesized. The insulin-sensitizing activity of 28 new compounds was evaluated in 3T3-L1 cells. The compounds 10a and 10f exhibited similar insulin-sensitizing activity with positive drug rosiglitazone. (C) 2010 Lei Tang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2010.11.008
• 作为产物：
  描述：

  4-碘苯甲醚 在 aluminum (III) chloride 、 copper(l) iodide 、 水 、 铜 、 potassium carbonate 、 对甲苯磺酸 、 sodium hydroxide 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 49.0h， 生成 2-[(2,6-Dichlorophenyl)amino]-5-hydroxy benzene acetic acid methyl ester
  参考文献：
  名称：

  Diclofenac derivatives with insulin-sensitizing activity

  摘要：

  A series of diclofenac derivatives were synthesized. The insulin-sensitizing activity of 28 new compounds was evaluated in 3T3-L1 cells. The compounds 10a and 10f exhibited similar insulin-sensitizing activity with positive drug rosiglitazone. (C) 2010 Lei Tang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2010.11.008

文献信息

• 2-anilino phenylacetic acid derivatives as inhibitors of PLA.sub.2 and
  申请人：American Home Products Corporation

  公开号：US05159085A1

  公开（公告）日：1992-10-27

  There are disclosed compounds of the formula ##STR1## wherein R is hydroxy, lower alkoxy or lower alkoxyamino; R.sup.1 is hydrogen or A(CH.sub.2).sub.n O--; R.sup.2 is hydrogen or A(CH.sub.2).sub.n O--, with the proviso that one of R.sup.1 and R.sup.2 is hydrogen; n is 1-2; A is phenoxyethyl, phenoxyphenyl or a group having the formula ##STR2## R.sup.3 is hydrogen, lower alkyl or phenyl; R.sup.4 is hydrogen or lower alkyl; or R.sup.3 and R.sup.4 taken together form a benzene ring; R.sup.5 is hydrogen or lower alkyl; R.sup.6 is hydrogen, halo or lower alkyl; and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastic cytoprotective agents.

  公开了以下式子的化合物：##STR1## 其中R为羟基，较低的烷氧基或较低的烷氧基氨基；R.sup.1为氢或A(CH.sub.2).sub.n O--；R.sup.2为氢或A(CH.sub.2).sub.n O--，但其中一个为氢；n为1-2；A为苯氧乙基，苯氧苯基或具有以下式子的基团：##STR2## R.sup.3为氢，较低的烷基或苯基；R.sup.4为氢或较低的烷基；或R.sup.3和R.sup.4一起形成苯环；R.sup.5为氢或较低的烷基；R.sup.6为氢，卤素或较低的烷基；以及其药理学上可接受的盐，并用于治疗炎症病症，例如风湿性关节炎，溃疡性结肠炎，牛皮癣和其他即时超敏反应；用于治疗白三烯介导的鼻支气管阻塞性疾病，例如过敏性鼻炎，过敏性支气管哮喘等；以及作为胃黏膜保护剂。
• 2-Anilino phenylacetic acid derivatives
  申请人：American Home Products Corporation

  公开号：US05021576A1

  公开（公告）日：1991-06-04

  There are disclosed compounds of the formula ##STR1## wherein R is hydroxy, lower alkoxy or lower alkoxyamino; R.sup.1 is hydrogen or A(CH.sub.2).sub.n O--; R.sup.2 is hydrogen or A(CH.sub.2).sub.n O--, with the proviso that one of R.sup.1 and R.sup.2 is A(CH.sub.2).sub.n O-- and the other is hydrogen; n is 1-2; A is phenoxyethyl, phenoxyphenyl or a group having the formula ##STR2## X is --N-- or ##STR3## Z is ##STR4## R.sup.3 is hydrogen, lower alkyl or phenyl; R.sup.4 is hydrogen or lower alkyl; or R.sup.3 and R.sup.4 taken together form a benzene ring; R.sup.5 is hydrogen or lower alkyl; R.sup.6 is hydrogen, halo or lower alkyl; and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.

  公开了一种化合物的式子 ##STR1## 其中R是羟基、低碳基氧或低碳基氧胺基；R.sup.1是氢或A(CH.sub.2).sub.n O--；R.sup.2是氢或A(CH.sub.2).sub.n O--，但其中一个是A(CH.sub.2).sub.n O--，另一个是氢；n为1-2；A是苯氧乙基、苯氧苯基或具有式子 ##STR2## X是--N--或 ##STR3## Z是 ##STR4## R.sup.3是氢、低碳基或苯基；R.sup.4是氢或低碳基；或R.sup.3和R.sup.4在一起形成苯环；R.sup.5是氢或低碳基；R.sup.6是氢、卤素或低碳基；以及其药物学上可接受的盐，以及它们在治疗炎症状况，如类风湿性关节炎、溃疡性结肠炎、牛皮癣和其他即时超敏反应；在治疗白三烯介导的鼻支气管阻塞性通气道疾病，如过敏性鼻炎、过敏性支气管哮喘等；以及作为胃黏膜保护剂的用途。
• Diclofenac derivatives with insulin-sensitizing activity
  作者：Jian Ta Wang、Ying Wang、Ji Quan Zhang、Xing Cui、Yi Zhang、Gao Feng Zhu、Lei Tang

  DOI：10.1016/j.cclet.2010.11.008

  日期：2011.4

  A series of diclofenac derivatives were synthesized. The insulin-sensitizing activity of 28 new compounds was evaluated in 3T3-L1 cells. The compounds 10a and 10f exhibited similar insulin-sensitizing activity with positive drug rosiglitazone. (C) 2010 Lei Tang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.