N'-[[3-[(3-aminopropylamino)methyl]phenyl]methyl]propane-1,3-diamine | 103898-17-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-[[3-[(3-aminopropylamino)methyl]phenyl]methyl]propane-1,3-diamine
• CAS: 103898-17-5
• 化学式: C₁₄H₂₆N₄
• 分子量: 250.387
• InChiKey: MHTONRWSEQKWDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  76.1
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N'-[[3-[(3-aminopropylamino)methyl]phenyl]methyl]propane-1,3-diamine 、 1,1-双(二乙氧基磷酰基)乙烯 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Bisphosphonate sequestering agents. Synthesis and preliminary evaluation for in vitro and in vivo uranium(VI) chelation

  摘要：

  A library of bisphosphonate-based ligands was prepared using solution-phase parallel synthesis and tested for its uranium-binding properties. With the help of a screening method, based on a chromophoric complex displacement procedure, 23 dipodal and tripodal chelates bearing bisphosphonate chelating functions were found to display very high affinity for the uranyl ion and were selected for evaluation of their in vivo uranyl-removal efficacy. Among them, 11 ligands induced a huge modification of the uranyl biodistribution by deviating the metal from kidney and bones to liver. Among the other ligands, the most potent was the dipodal bisphosphonate 3C which reduced the retention of uranyl and increased its excretion by around 10% of the injected metal. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.01.018
• 作为产物：
  描述：

  1,3-丙二胺 、 间二溴苄 在 氢氧化钾 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 12.0h， 以98%的产率得到N'-[[3-[(3-aminopropylamino)methyl]phenyl]methyl]propane-1,3-diamine
  参考文献：
  名称：

  Bisphosphonate sequestering agents. Synthesis and preliminary evaluation for in vitro and in vivo uranium(VI) chelation

  摘要：

  A library of bisphosphonate-based ligands was prepared using solution-phase parallel synthesis and tested for its uranium-binding properties. With the help of a screening method, based on a chromophoric complex displacement procedure, 23 dipodal and tripodal chelates bearing bisphosphonate chelating functions were found to display very high affinity for the uranyl ion and were selected for evaluation of their in vivo uranyl-removal efficacy. Among them, 11 ligands induced a huge modification of the uranyl biodistribution by deviating the metal from kidney and bones to liver. Among the other ligands, the most potent was the dipodal bisphosphonate 3C which reduced the retention of uranyl and increased its excretion by around 10% of the injected metal. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.01.018

文献信息

• COMPOSITIONS AND METHODS COMPRISING A BIOCIDAL POLYAMINE
  申请人：Curza Global, LLC

  公开号：US20150038512A1

  公开（公告）日：2015-02-05

  Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.

  本发明涉及一种包含聚胺化合物的化合物、组合物和方法，可用于杀死、分散、治疗或减少生物膜，或抑制或大幅预防生物膜的形成。在某些方面，本发明涉及包含聚胺化合物的化合物、组合物和方法，其具有针对能够形成生物膜的各种细菌菌株的抗微生物或分散活性。
• METHODS OF USE COMPRISING A BIOCIDAL POLYAMINE
  申请人：Curza Global, LLC

  公开号：US20150038705A1

  公开（公告）日：2015-02-05

  Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.

  本发明描述了包含聚胺化合物的化合物、组合物和方法，可用于杀灭、分散、治疗、减少生物膜和/或抑制或实质性地预防生物膜形成。在某些方面，本发明涉及包含具有抗微生物或分散活性的聚胺化合物的化合物、组合物和方法，用于对能够形成生物膜的各种细菌菌株进行处理。
• METHODS OF USE FOR COMPOSITIONS COMPRISING A BIOCIDAL POLYAMINE
  申请人：The University of Utah

  公开号：US20140350017A1

  公开（公告）日：2014-11-27

  Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.

  本发明涉及包含聚胺化合物的化合物、组合物和方法，可用于杀灭、分散、治疗、减少生物膜，以及抑制或几乎完全防止生物膜形成。在某些方面，本发明涉及包含聚胺化合物的化合物、组合物和方法，这些化合物具有抗微生物或分散活性，可对能够形成生物膜的各种细菌菌株产生影响。
• Methods comprising a biocidal polyamine
  申请人：Curza Global, LLC

  公开号：US10440955B2

  公开（公告）日：2019-10-15

  Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.

  本发明描述了包含多胺化合物的化合物、组合物和方法，这些化合物、组合物和方法可用于杀灭、分散、处理或减少生物膜，或用于抑制或基本防止生物膜的形成。在某些方面，本发明涉及包含多胺化合物的化合物、组合物和方法，这些化合物对能够形成生物膜的各种细菌菌株具有抗菌或分散活性。
• COMPOSITIONS COMPRISING A BIOCIDAL POLYAMINE
  申请人：Curza Global, LLC

  公开号：US20160330962A1

  公开（公告）日：2016-11-17

  Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.