1,3-bis(2-aminoethylaminomethyl)benzene | 103898-18-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-bis(2-aminoethylaminomethyl)benzene
• 英文别名: N'-[[3-[(2-aminoethylamino)methyl]phenyl]methyl]ethane-1,2-diamine
• CAS: 103898-18-6
• 化学式: C₁₂H₂₂N₄
• 分子量: 222.333
• InChiKey: MKFUMGIPOGNFOO-UHFFFAOYSA-N

物化性质

• 沸点：
  392.3±32.0 °C(Predicted)
• 密度：
  1.043±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  76.1
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-bis(2-aminoethylaminomethyl)benzene 、 1,1-双(二乙氧基磷酰基)乙烯 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Bisphosphonate sequestering agents. Synthesis and preliminary evaluation for in vitro and in vivo uranium(VI) chelation

  摘要：

  A library of bisphosphonate-based ligands was prepared using solution-phase parallel synthesis and tested for its uranium-binding properties. With the help of a screening method, based on a chromophoric complex displacement procedure, 23 dipodal and tripodal chelates bearing bisphosphonate chelating functions were found to display very high affinity for the uranyl ion and were selected for evaluation of their in vivo uranyl-removal efficacy. Among them, 11 ligands induced a huge modification of the uranyl biodistribution by deviating the metal from kidney and bones to liver. Among the other ligands, the most potent was the dipodal bisphosphonate 3C which reduced the retention of uranyl and increased its excretion by around 10% of the injected metal. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.01.018
• 作为产物：
  描述：

  乙二胺 、 间二溴苄 在 氢氧化钾 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 12.0h， 以98%的产率得到1,3-bis(2-aminoethylaminomethyl)benzene
  参考文献：
  名称：

  Bisphosphonate sequestering agents. Synthesis and preliminary evaluation for in vitro and in vivo uranium(VI) chelation

  摘要：

  A library of bisphosphonate-based ligands was prepared using solution-phase parallel synthesis and tested for its uranium-binding properties. With the help of a screening method, based on a chromophoric complex displacement procedure, 23 dipodal and tripodal chelates bearing bisphosphonate chelating functions were found to display very high affinity for the uranyl ion and were selected for evaluation of their in vivo uranyl-removal efficacy. Among them, 11 ligands induced a huge modification of the uranyl biodistribution by deviating the metal from kidney and bones to liver. Among the other ligands, the most potent was the dipodal bisphosphonate 3C which reduced the retention of uranyl and increased its excretion by around 10% of the injected metal. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.01.018

文献信息

• AMIN FÜR EMISSIONSARME EPOXIDHARZ-ZUSAMMENSETZUNGEN
  申请人：Sika Technology AG

  公开号：EP3138864A1

  公开（公告）日：2017-03-08

  Die vorliegende Erfindung betrifft die Verwendung eines Amins der Formel (I) als Härter für Epoxidharze. Das Amin der Formel (I) ist niedrigviskos und geruchsarm, mit üblichen Epoxidharzen überraschend gut verträglich und verdünnt diese gut. Härter enthaltend das Amin der Formel (I) weisen eine sehr hohe Reaktivität auf, bleiben aber überraschenderweise trotzdem weitgehend frei von Blushing. Mit dem Amin der Formel (I) sind emissionsarme Epoxidharz-Zusammensetzungen zugänglich, welche gut verarbeitbar sind, rasch aushärten und qualitativ hochstehende Kunststoffe bilden.

  本发明涉及使用式（I）胺作为环氧树脂的固化剂。式（I）胺具有低粘度和低气味，与传统环氧树脂的相容性出奇地好，稀释效果也很好。含有式（I）胺的硬化剂具有极高的反应活性，但令人惊讶的是，它基本上不会产生褪色现象。有了式 (I) 的胺，就有了低排放的环氧树脂组合物，这种组合物易于加工，固化速度快，并能形成高质量的塑料。
• Bisphosphonate sequestering agents. Synthesis and preliminary evaluation for in vitro and in vivo uranium(VI) chelation
  作者：Marcin Sawicki、Delphine Lecerclé、Gérard Grillon、Béatrice Le Gall、Anne-Laure Sérandour、Jean-Luc Poncy、Théodorine Bailly、Ramon Burgada、Marc Lecouvey、Vincent Challeix、Antoine Leydier、Stephane Pellet-Rostaing、Eric Ansoborlo、Frédéric Taran

  DOI：10.1016/j.ejmech.2008.01.018

  日期：2008.12

  A library of bisphosphonate-based ligands was prepared using solution-phase parallel synthesis and tested for its uranium-binding properties. With the help of a screening method, based on a chromophoric complex displacement procedure, 23 dipodal and tripodal chelates bearing bisphosphonate chelating functions were found to display very high affinity for the uranyl ion and were selected for evaluation of their in vivo uranyl-removal efficacy. Among them, 11 ligands induced a huge modification of the uranyl biodistribution by deviating the metal from kidney and bones to liver. Among the other ligands, the most potent was the dipodal bisphosphonate 3C which reduced the retention of uranyl and increased its excretion by around 10% of the injected metal. (C) 2008 Elsevier Masson SAS. All rights reserved.