2,4,4-trimethyl-valeric acid amide | 144598-76-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,4,4-trimethyl-valeric acid amide
• 英文别名: 2,4,4-Trimethyl-valeriansaeure-amid；4-Carbamoyl-2,2-dimethyl-pentan；2,4,4-Trimethylpentanamide
• CAS: 144598-76-5
• 化学式: C₈H₁₇NO
• mdl: MFCD00068809
• 分子量: 143.229
• InChiKey: NHDAIKHCCBOFSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,4,4-三甲基戊酸 在 氯化亚砜 、 乙醚 、 氨 作用下， 生成 2,4,4-trimethyl-valeric acid amide
  参考文献：
  名称：

  New Compounds. Methylneopentylacetic Acid (2,4,4-Trimethylpentanoic Acid), its Methyl Ester, Amide and Acetanilide

  摘要：

  DOI：

  10.1021/ja01852a601

文献信息

• [EN] AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE<br/>[FR] COMPOSÉS AMINO HÉTÉROARYLES COMME MODULATEURS DE LA BÊTA-SECRÉTASE ET PROCÉDÉS D'UTILISATION
  申请人：AMGEN INC

  公开号：WO2011063233A1

  公开（公告）日：2011-05-26

  The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein ring A, B1, B2, B3, L, R1, R4, R5 and m of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

  本发明涵盖了一类新化合物，用于调节β-分泌酶酶活性，治疗由β-分泌酶介导的疾病，包括阿尔茨海默病（AD）和相关疾病。在一个实施例中，这些化合物具有一般的化学式I，其中化合物I的环A、B1、B2、B3、L、R1、R4、R5和m在此定义。该发明还包括将这些化合物用于制备药物组合物，用于治疗与β-分泌酶蛋白活性相关的疾病和症状，包括例如阿尔茨海默病（AD）、认知缺陷、认知损害、精神分裂症和其他与大脑斑块形成和/或沉积有关和/或由此引起的中枢神经系统疾病。该发明还包括化合物I的进一步实施例、中间体和用于制备化合物I的过程。
• Perfluorvinyl ether monomer having sulfonamide group
  申请人：——

  公开号：US20040122256A1

  公开（公告）日：2004-06-24

  A perfluorovinyl ether monomer represented by the following formula (1): 1 wherein: m is an integer of from 0 to 5; n is an integer of from 1 to 5; and each of R 1 and R 2 independently represents a hydrogen atom, an unsubstituted or substituted C 1 -C 10 hydrocarbon group, or a substituted silyl group, with the proviso that, when each of R 1 and R 2 is independently the hydrocarbon group or the substituted silyl group, R 1 and R 2 are optionally bonded together, thereby forming a ring. Also disclosed are a method for producing the perfluorovinyl ether monomer; a fluorinated polymer obtained from the monomer and a method for producing the same; a polymer film obtained from the polymer; a modified or crosslinked polymer film obtained from the polymer film; and a solid polymer electrolyte membrane obtained from the modified or crosslinked polymer film.

  以下为化学式（1）所代表的一种全氟乙烯醚单体： 其中：m为0至5的整数；n为1至5的整数；R1和R2各自独立地表示氢原子、未取代或取代的C1-C10烃基或取代的硅烷基，但当R1和R2各自为烃基或取代的硅烷基时，R1和R2可以选择性地结合在一起，从而形成一个环。此外，还公开了一种制备全氟乙烯醚单体的方法；一种从该单体获得的氟化聚合物及其制备方法；从该聚合物获得的聚合物薄膜；从聚合物薄膜获得的改性或交联聚合物薄膜；以及从改性或交联聚合物薄膜获得的固态聚合物电解质膜。
• PERFLUOROVINYL ETHER MONOMER HAVING A SULFONAMIDO GROUP
  申请人：Ikeda Masanori

  公开号：US20070088142A1

  公开（公告）日：2007-04-19

  A perfluorovinyl ether monomer represented by the following formula (1): wherein: m is an integer of from 0 to 5; n is an integer of from 1 to 5; and each of R1 and R2 independently represents a hydrogen atom, an unsubstituted or substituted C1-C10 hydrocarbon group, or a substituted silyl group, with the proviso that, when each of the R1 and R2 is independently the hydrocarbon group or the substituted silyl group, R1 and R2 are optionally bonded together, thereby forming a ring. Also disclosed are a method for producing the perfluorovinyl ether monomer; a fluorinated polymer obtained from the monomer and a method for producing the same; a polymer film obtained from the polymer; a modified or crosslinked polymer film obtained from the polymer film; and a polymeric solid electrolytesolid polymer electrolyte filmmembrane obtained from the modified or crosslinked polymer film

  下列化学式（1）所示的全氟乙烯醚单体：其中，m为0至5的整数，n为1至5的整数，R1和R2各自独立地表示氢原子、未取代或取代的C1-C10烃基或取代的硅烷基，但当R1和R2各自为烃基或取代的硅烷基时，R1和R2可选择结合形成环。此外，还公开了制备全氟乙烯醚单体的方法，从该单体获得的氟化聚合物以及制备其的方法，从该聚合物获得的聚合物薄膜，从该聚合物薄膜获得的改性或交联聚合物薄膜，以及从改性或交联聚合物薄膜获得的聚合物固体电解质/固体聚合物电解质薄膜。
• Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use
  申请人：Cheng Yuan

  公开号：US20120329830A1

  公开（公告）日：2012-12-27

  The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein ring A, B 1 , B 2 , B 3 , L, R 1 , R 4 , R 5 and m of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

  本发明涉及一类新的化合物，可用于调节β-分泌酶酶活性和治疗β-分泌酶介导的疾病，包括阿尔茨海默病（AD）和相关疾病。在一种实施例中，所述化合物具有一般式I，其中环A、B1、B2、B3、L、R1、R4、R5和m在本文中有定义。本发明还包括使用这些化合物制备药物组合物，用于治疗与β-分泌酶蛋白活性相关的疾病和症状，例如阿尔茨海默病（AD）、认知缺陷、认知障碍、精神分裂症以及与大脑斑块形成和/或沉积相关和/或由其引起的其他中枢神经系统疾病。本发明还包括式I的进一步实施例、中间体和用于制备式I化合物的过程。
• PERFLUOROVINYL ETHER MONOMER HAVING SULFONAMIDE GROUP
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP1359142A1

  公开（公告）日：2003-11-05

  A perfluorovinyl ether monomer represented by the following formula (1): wherein: m is an integer of from 0 to 5; n is an integer of from 1 to 5; and each of R1 and R2 independently represents a hydrogen atom, an unsubstituted or substituted C1-C10 hydrocarbon group, or a substituted silyl group, with the proviso that, when each of R1 and R2 is independently the hydrocarbon group or the substituted silyl group, R1 and R2 are optionally bonded together, thereby forming a ring. Also disclosed are a method for producing the perfluorovinyl ether monomer; a fluorinated polymer obtained from the monomer and a method for producing the same; a polymer film obtained from the polymer; a modified or crosslinked polymer film obtained from the polymer film; and a solid polymer electrolyte membrane obtained from the modified or crosslinked polymer film.

  由下式（1）代表的全氟乙烯基醚单体： 其中：m 为 0 至 5 的整数；n 为 1 至 5 的整数；R1 和 R2 分别独立地代表氢原子、未取代或取代的 C1-C10 烃基或取代的硅烷基，但当 R1 和 R2 分别独立地代表烃基或取代的硅烷基时，R1 和 R2 可任选地键合在一起，从而形成一个环。还公开了一种生产全氟乙烯基醚单体的方法；一种由该单体获得的含氟聚合物及其生产方法；一种由该聚合物获得的聚合物薄膜；一种由该聚合物薄膜获得的改性或交联聚合物薄膜；以及一种由该改性或交联聚合物薄膜获得的固体聚合物电解质膜。