2,6-di-n-propylaniline | 261527-91-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-di-n-propylaniline
• 英文别名: 2,6-Dipropylaniline
• CAS: 261527-91-7
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: WFGHUOGOUOTVBO-UHFFFAOYSA-N

物化性质

• 沸点：
  279.9±9.0 °C(Predicted)
• 密度：
  0.931±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-di-n-propylaniline 在 盐酸 、 sodium nitrite 、 水 、 tin(ll) chloride 作用下， 以 水 为溶剂， 反应 12.0h， 生成 2,6-bis(2-propyl)phenylhydrazine hydrochloride
  参考文献：
  名称：

  Identification and Structure–Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors

  摘要：

  Enterovirus 71 (EV71) plays an important role in hand-foot-and-mouth disease. In this study, a series of diarylhydrazide analogues was synthesized, and the systematic exploration of SAP. led to potent enterovirus inhibitors, of which compound 15 exhibits significant improvements in inhibition potency with an EC50 value of 0.02 mu M against EV71. It is very interesting that this class of diarylhydrazides exhibits activities against a series of human enteroviruses at the picomolar level, including EV71 and Coxsackieviruses B1 (CVB1), CVB2, CVB3, CVB4, CVB5, and CVB6 (EC50 as low as 0.5 nM). Compared with the reference antienterovirus drug 1 (enviroxime) and known inhibitor 5 (WIN 51711), the four highly selective compounds 15, 27, 41 and 47 inhibited EV71 replication with EC50 values of 0.17-0.02 mu M and SI values in range of 978.4-12338. A preliminary mechanistic study indicated that VP1 might be the target site for this type of compound.

  DOI：

  10.1021/acs.jmedchem.5b01803
• 作为产物：
  描述：

  2,6-Diallylanilin 在 palladium on activated charcoal 、 氢气 作用下， 以 甲醇 为溶剂， 生成 2,6-di-n-propylaniline
  参考文献：
  名称：

  Aza-Claisen 重排是合成用于生产高效乙烯分解催化剂的专用苯胺的关键步骤

  摘要：

  采用氮杂-克莱森重排和随后还原生成的苯胺被证明是合成廉价 2-异丙基-6-甲基苯胺类似物的有效方法，从而消除了与后者价格高和可用性低相关的瓶颈。获得的苯胺衍生物被用于合成一系列具有 CAAC 配体的亲脂性 Hoveyda-Grubbs 型配合物，催化剂在乙烯分解反应中特别有效。这个家族中最好的成员拥有笨重的秒- 丁基取代基以 3 ppm 的负载量和在乙烯 3.5 存在下使用，在油酸甲酯的乙烯醇解中优于基于 2-异丙基-6-甲基苯胺的主要催化剂，实现高达 192 000 的 TON，这使其具有价值用于大规模工业生产的候选者。

  DOI：

  10.1039/d3cy00395g

文献信息

• Method for producing oligomer and catalyst
  申请人：ENEOS Corporation

  公开号：US10815317B2

  公开（公告）日：2020-10-27

  The present invention provides a method for preparing an oligomer and a catalyst comprising a step of oligomerizing a polymerizable monomer containing an olefin in the presence of a catalyst, which comprises (A) a complex of a diimine compound and at least one metal selected from the group consisting of Group 8 elements, Group 9 elements and Group 10 elements, (B) a mixture of a pyridine diimine compound and an iron salt and/or an iron complex, (C) methylaluminoxane and/or a boron compound, and (D) an organoaluminum compound other than methylaluminoxane and/or an organozinc compound. The components (A), (B), (C) and (D) described above are respectively as defined in the present Description.

  本发明提供了一种制备寡聚物和催化剂的方法，包括在催化剂存在的情况下，通过在含有烯烃的可聚合单体存在下进行寡聚化的步骤，所述催化剂包括(A)二亚胺化合物和来自第8、第9和第10族元素中至少一种金属的络合物，(B)吡啶二亚胺化合物和铁盐和/或铁配合物的混合物，(C)甲基铝氧烷和/或硼化合物，以及(D)除甲基铝氧烷和/或有机锌化合物之外的有机铝化合物。上述组分(A)、(B)、(C)和(D)分别如本说明中所定义。
• [EN] GROUP 8 TRANSITION METAL CATALYSTS AND METHOD FOR MAKING SAME AND PROCESS FOR USE OF SAME IN OLEFIN DISPROPORTIONATION REACTIONS<br/>[FR] CATALYSEURS DE MÉTAUX DE TRANSITION DU GROUPE 8, LEUR PROCÉDÉ DE FABRICATION, ET LEUR PROCÉDÉ D'UTILISATION DANS LES RÉACTIONS DE DISPROPORTIONATION DES OLÉFINES
  申请人：XIA LING

  公开号：WO2017185324A1

  公开（公告）日：2017-11-02

  These catalyst compounds are represented by the formula (I and VI): wherein M is a Group 8 metal; X is an anionic ligand; L is a neutral two-electron donor ligand; A is a monotopic or ditopic chelating ligand. The present invention also relates to an easy applicable catalyst synthesis and the application in different olefin metathesis processes, e.g. Reaction Injection Molding (RIM), rotational molding, vacuum infusion, vacuum forming, process for conversion of fatty acids and fatty acid esters or mixtures thereof, in -olefins, dicarboxylic acids or dicarboxylic esters, etc.

  这些催化剂化合物由公式(I和VI)表示：其中M是第8族金属；X是一个阴离子配体；L是一个中性双电子供体配体；A是一个单齿或双齿螯合配体。本发明还涉及一种易于应用的催化剂合成方法及其在不同烯烃复分解过程中的应用，例如反应注射成型(RIM)、旋转成型、真空灌注、真空成型、脂肪酸和脂肪酸酯或其混合物的转化过程，以及内烯烃、二元羧酸或二元羧酸酯等的制备过程。
• [EN] PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS<br/>[FR] COMPOSÉS DE PHOSPHINYLAMIDINE, COMPLEXES DE MÉTAL, SYSTÈMES DE CATALYSEUR, ET LEUR UTILISATION POUR OLIGOMÉRISER OU POLYMÉRISER DES OLÉFINES
  申请人：CHEVRON PHILLIPS CHEMICAL CO

  公开号：WO2011082192A1

  公开（公告）日：2011-07-07

  N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.

  描述了N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物、N2-膦胺酸盐金属盐络合物。还公开了制备N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物的方法。还公开了利用N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物的催化剂系统，以及利用N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物进行烯烃的寡聚和/或聚合的用途。
• Polymerization of Lactide with Zinc and Magnesium β-Diiminate Complexes:  Stereocontrol and Mechanism
  作者：Bradley M. Chamberlain、Ming Cheng、David R. Moore、Tina M. Ovitt、Emil B. Lobkovsky、Geoffrey W. Coates

  DOI：10.1021/ja003851f

  日期：2001.4.1

  alkoxides based upon a beta-diiminate ligand framework has been prepared. [(BDI-1)ZnO(i)Pr](2) [(BDI-1) = 2-((2,6-diisopropylphenyl)amido)-4-((2,6-diisopropylphenyl)imino)-2-pentene] exhibited the highest activity and stereoselectivity of the zinc complexes studied for the polymerization of rac- and meso-lactide to poly(lactic acid) (PLA). [(BDI-1)ZnO(i)()Pr](2) polymerized (S,S)-lactide to isotactic

  已经制备了一系列基于 β-二亚胺配体框架的锌 (II) 和镁 (II) 醇盐。[(BDI-1)ZnO(i)Pr](2) [(BDI-1) = 2-((2,6-二异丙基苯基)酰胺基)-4-((2,6-二异丙基苯基)亚氨基)-2-戊烯] 在研究外消旋和内消旋丙交酯聚合成聚乳酸 (PLA) 的锌配合物中表现出最高的活性和立体选择性。[(BDI-1)ZnO(i)()Pr](2) 将 (S,S)-丙交酯聚合成全同立构 PLA，没有单体差向异构化，外消旋丙交酯变成异同立构 PLA (P(r) = 0.94 at 0° C)，以及内消旋丙交酯到间规 PLA（P(r) = 0.76 在 0 摄氏度）。除了数均分子量与转化率曲线和单体与催化剂比率的线性性质外，聚合反应是活跃的，这由分离的聚合物的窄多分散性证明。β-二亚胺配体上的取代基对聚合过程产生显着影响，影响立体选择性程度和聚合速率。[(BDI-1)ZnO(i)Pr](2)
• [EN] PHOSPHINYL FORMAMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS<br/>[FR] COMPOSÉS PHOSPHINYL FORMAMIDINE, COMPLEXES MÉTALLIQUES, SYSTÈMES DE CATALYSEUR, ET LEUR UTILISATION POUR OLIGOMÉRISER OU POLYMÉRISER DES OLÉFINES
  申请人：CHEVRON PHILLIPS CHEMICAL CO

  公开号：WO2015094207A1

  公开（公告）日：2015-06-25

  N2-phosphinyl formamidine compounds and N2-phosphinyl formamidine metal salt complexes are described. Methods for making N2-phosphinyl formamidine compounds and N2-phosphinyl formamidine metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl formamidine metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds and N2- phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.

  描述了N2-磷酰基甲酰胺化合物和N2-磷酰基甲酰胺金属盐配合物。还公开了制备N2-磷酰基甲酰胺化合物和N2-磷酰基甲酰胺金属盐配合物的方法。还公开了利用N2-磷酰基甲酰胺金属盐配合物的催化剂体系，以及利用N2-磷酰基胺化合物和N2-磷酰基胺金属盐配合物进行烯烃的寡聚和/或聚合的用途。