β-hydroxytyrosine | 6809-69-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: β-hydroxytyrosine
• 英文别名: 3-<4-Hydroxy-phenyl>-serin；2-amino-3-hydroxy-3-(4-hydroxy-phenyl)-propionic acid；2-Amino-3-hydroxy-3-(4-hydroxy-phenyl)-propionsaeure；α-Amino-β-(4-oxy-phenyl)-hydracrylsaeure；α-Amino-β-oxy-β-(4-oxy-phenyl)-propionsaeure；β-(4-Oxy-phenyl)-serin；2-Amino-3-hydroxy-3-(4-hydroxyphenyl)propanoic acid
• CAS: 6809-69-4
• 化学式: C₉H₁₁NO₄
• 分子量: 197.191
• InChiKey: RKCRKDKQUDBXAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  β-hydroxytyrosine 生成 对羟基苯甲醛
  参考文献：
  名称：

  酪氨酸从生物上合成管蛋白和黄嘌呤

  摘要：

  （2S）-酪氨酸（5）立体定向地结合到结核菌素（1）中，保留了3- -S质子，保留了2-S质子；带有叶黄素（4）的平行途径很明显，酪氨酸的3- -R质子的立体定向保留。报道了与-和-3-羟基酪氨酸有关的结核菌素生物合成的实验结果。

  DOI：

  10.1016/s0040-4039(01)81412-x
• 作为产物：
  描述：

  S-β-hydroxytyrosyl-N-acetyl cysteamine thioester 在 thioesterase Bhp 作用下， 生成 β-hydroxytyrosine
  参考文献：
  名称：

  硫代酯酶Bhp参与巴尔希霉素支链淀粉生物合成过程中β-羟基酪氨酸的形成。

  摘要：

  将Bhp鉴定为能催化β-OH-Tyr-SNAC的硫酯键水解的硫酯酶是充分了解β-OH-Tyr作为Balhimycin和其他β-含OH-Tyr的糖肽抗生素。

  DOI：

  10.1002/cbic.200900600

文献信息

• [EN] N-ACYL-TYROSINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE N-ACYLE-TYROSINE ET LEURS UTILISATIONS
  申请人：UNIV OF PRINCE EDWARD ISLAND

  公开号：WO2021046651A1

  公开（公告）日：2021-03-18

  Provided herein are compounds of Formula A, methods for the preparation thereof, and uses thereof for treating or preventing bacterial infections.

  本文提供了A式化合物，其制备方法以及用于治疗或预防细菌感染的用途。
• Process for Producing Dipeptides
  申请人：Hashimoto Shin-ichi

  公开号：US20070243581A1

  公开（公告）日：2007-10-18

  The present invention provides: a protein having dipeptide-synthesizing activity or a protein for dipeptide synthesis; DNA encoding the protein having dipeptide-synthesizing activity or the protein for dipeptide synthesis; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein having dipeptide-synthesizing activity; an enzymatic process for producing a dipeptide using the protein having dipeptide-synthesizing activity or the protein for dipeptide synthesis; and a process for producing a dipeptide using, as an enzyme source, a culture of a microorganism or a transformant having the ability to produce the protein having dipeptide-synthesizing activity or the protein for dipeptide synthesis, or the like.

  本发明提供了：具有二肽合成活性的蛋白质或用于二肽合成的蛋白质；编码具有二肽合成活性的蛋白质或用于二肽合成的蛋白质的DNA；包含该DNA的重组DNA；携带重组DNA的转化体；用于生产具有二肽合成活性的蛋白质的过程；利用具有二肽合成活性的蛋白质或用于二肽合成的蛋白质的酶制剂进行二肽生产的酶法过程；以及利用具有二肽合成活性的蛋白质或用于二肽合成的蛋白质的生产能力的微生物或转化体的培养物等作为酶源进行二肽生产的过程。
• ISOPRENOIDS AND METHODS OF MAKING THEREOF
  申请人：NORTH CAROLINA STATE UNIVERSITY

  公开号：US20220162188A1

  公开（公告）日：2022-05-26

  Disclosed are methods for preparing isoprenoid subunits, as well as methods of employing these isoprenoid subunits for the synthesis of isoprenoids. Also provided are isoprenoids prepared using the methods described herein.

  本发明公开了制备异戊二烯基亚基的方法，以及利用这些异戊二烯基亚基合成异戊二烯类化合物的方法。还提供了使用本发明所述方法制备的异戊二烯类化合物。
• Genes and proteins for the biosynthesis of the glycopeptide antibiotic A40926
  申请人：Vicuron Pharmaceuticals, Inc.

  公开号：EP1413626A1

  公开（公告）日：2004-04-28

  The present invention relates to the field of antibiotics and more specifically to the isolation of nucleic acid molecules that code for the biosynthetic pathway of the glycopeptide antibiotic A40926. Disclosed are the functions of the gene products involved in A40926 production. The present invention provides biosynthetic genes that code for A40926 production, the encoded polypeptides, the recombinant vectors comprising the nucleic acid sequences that encode said polypeptides, the host cells transformed with said vectors and methods for producing glycopeptide antibiotics using said transformed host cells, including methods for producing A40926, a precursor thereof, a derivative thereof or a modified glycopeptide different from A40926 or a precursor thereof.

  本发明涉及抗生素领域，更具体地说，涉及分离编码糖肽抗生素 A40926 生物合成途径的核酸分子。本发明公开了参与 A40926 生产的基因产物的功能。本发明提供了编码生产 A40926 的生物合成基因、编码的多肽、包含编码所述多肽的核酸序列的重组载体、用所述载体转化的宿主细胞以及使用所述转化的宿主细胞生产糖肽抗生素的方法，包括生产 A40926、其前体、其衍生物或不同于 A40926 或其前体的修饰糖肽的方法。
• Genes and proteins for the biosynthesis of the glycopeptide antibiotic teicoplanin
  申请人：Vicuron Pharmaceuticals, Inc.

  公开号：EP1460085A1

  公开（公告）日：2004-09-22

  The present invention relates to the field of antibiotics, and more specifically to the isolation of nucleic acid molecules that code for the biosynthetic pathway of the glycopeptide antibiotic teicoplanin. Disclosed are the functions of the gene products involved in teicoplanin production. The present invention provides novel biosynthetic genes that code for teicoplanin production, the encoded polypeptides, the recombinant vectors comprising the nucleic acid sequences that encode said polypeptides, the host cells transformed,with said vectors and methods for producing glycopeptide antibiotics using said transformed host cells, including methods for producing teicoplanin, a precursor thereof, a derivative thereof or a modified glycopeptide different from teicoplanin or a precursor thereof.

  本发明涉及抗生素领域，更具体地说，涉及分离编码糖肽类抗生素替考拉宁生物合成途径的核酸分子。本发明还公开了参与生产替考拉宁的基因产物的功能。本发明提供了编码生产替考拉宁的新型生物合成基因、编码的多肽、包含编码所述多肽的核酸序列的重组载体、用所述载体转化的宿主细胞以及使用所述转化的宿主细胞生产糖肽类抗生素的方法，包括生产替考拉宁、其前体、其衍生物或不同于替考拉宁或其前体的改良糖肽的方法。