Synthesis of 3-Sarcosine-, 3-Glycine-, and 3-L-Alanine-6-Glycine-Bradykinin and 3-Glycine-Bradykinin.
作者:Kenji Suzuki、Takashi Abiko
DOI:10.1248/cpb.15.1212
日期:——
The three analogs of bradykinin are described in which L-proline residue in 3-position of 6-glycine-bradykinin is substituted for sarcosine, glycine, and L-alanine residue respectively. 3-Glycine-bradykinin and its O-acetyl compound are also described. The biological activity of the five analogs is compared with that of bradykinin on an isolated guinea pig ileum.
描述了三种布拉迪激肽的类似物,其中6-甘氨酸-布拉迪激肽的3位L-脯氨酸残基分别被萨氨酸、甘氨酸和L-丙氨酸残基替代。还描述了3-甘氨酸-布拉迪激肽及其O-乙酰化合物。这五种类似物的生物活性与布拉迪激肽在孤立的豚鼠回肠上的活性进行了比较。