2-乙基-5-羟基嘧啶 | 90339-11-0

• 物质功能分类: 医药中间体 - 杂环化合物 - 嘧啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2-乙基-5-羟基嘧啶
• 英文名称: 2-ethyl-5-pyrimidinol
• 英文别名: 2-ethylpyrimidin-5-ol
• CAS: 90339-11-0
• 化学式: C₆H₈N₂O
• 分子量: 124.142
• InChiKey: QTIJUIDBXKIGLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  2-乙基-5-羟基嘧啶 生成 diethoxy-(2-ethylpyrimidin-5-yl)oxy-sulfanylidene-λ5-phosphane
  参考文献：
  名称：

  MAURER, F.

  摘要：

  DOI：

文献信息

• [EN] INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR TREATING DISEASE<br/>[FR] INHIBITEURS DE DIHYDROCÉRAMIDE DÉSATURASE POUR LE TRAITEMENT DE MALADIES
  申请人：CENTAURUS THERAPEUTICS

  公开号：WO2018112077A1

  公开（公告）日：2018-06-21

  Disclosed herein are dihydroceramide desaturase 1 (Des1) inhibitor compounds and compositions, which are useful in the treatment of diseases, such as metabolic, cardiovascular, fibrotic, autoimmune/chronic inflammatory diseases, cystic fibrosis, various cancers, neurodegenerative diseases, lipid storage disorders, and ischemia/reperfusion injury, where inhibition of Des1 is expected to be therapeutic to a patient. Methods of inhibition of Des1 activity in a human or animal subject are also provided.

  本文披露了二氢神经酰胺脱饱和酶1（Des1）抑制剂化合物和组合物，这些化合物在治疗疾病方面非常有用，如代谢性疾病、心血管疾病、纤维化疾病、自身免疫/慢性炎症性疾病、囊性纤维化、各种癌症、神经退行性疾病、脂质储存障碍和缺血/再灌注损伤，预期通过抑制Des1对患者具有治疗作用。还提供了在人类或动物受试者中抑制Des1活性的方法。
• Phosphorus esters of 5-pyrimidinols
  申请人：The Dow Chemical Co.

  公开号：US04429125A1

  公开（公告）日：1984-01-31

  Compounds of the formula: ##STR1## wherein R is hydrogen; alkyl of 1 to 8 carbons; alkylthiomethyl, alkylsulfinylmethyl or alkylsulfonylmethyl wherein alkyl contains 1 to 4 carbons; phenyl; phenylthio; alkylthio, alkylsulfinyl or alkylsulfonyl wherein alkyl contains 1 to 4 carbons; or alkylthio-ethylthio wherein alkyl contains 1 to 2 carbons; R' is hydrogen, methyl or alkylthio of 1 to 2 carbons; R" is hydrogen or methyl; X is oxygen or sulfur; R'" is alkyl of 1 to 2 carbons; and R"" is --OR'" or --S-alkyl of 1 to 4 carbons, are highly useful insecticides which are paricularly valuable when applied to the soil, but are also useful applied to foliage of crops or trees. Especially good control is obtained of corn rootworm, codling moth, thrips, leafhoppers, and nematodes. The compounds are conveniently applied in the form of a composition containing a pesticidal carrier such as an inert solvent or a finely divided inert solid in which case the composition is preferably granulated. An effective application rate is in the range of about 0.1 to about 5 pounds per acre when soil incorporated, and about 0.5 to about 2,000 ppm for foliar applications.

  该公式化合物为：##STR1## 其中R为氢；1至8个碳的烷基；烷基硫甲基，烷基亚砜基甲基或烷基砜基甲基，其中烷基含有1至4个碳；苯基；苯基硫；烷基硫，烷基亚砜基或烷基砜基，其中烷基含有1至4个碳；或烷基硫乙硫，其中烷基含有1至2个碳；R'为氢，甲基或1至2个碳的烷基硫；R"为氢或甲基；X为氧或硫；R'"为1至2个碳的烷基；R""为--OR'"或--S-1至4个碳的烷基，这些化合物是高效的杀虫剂，尤其在施用于土壤时具有重要价值，但也适用于作物或树木的叶面施用。特别适用于玉米根蠕虫、苹果蠹虫、蓟马、叶蝉和线虫的有效控制。这些化合物可以方便地以含有杀虫剂载体的形式施用，如惰性溶剂或细粉惰性固体，此时最好是制成颗粒状。有效的施用量范围约为每英亩0.1至5磅（土壤施用时），叶面施用约为0.5至2,000 ppm。
• Novel Compounds
  申请人：Chapman David

  公开号：US20080221139A1

  公开（公告）日：2008-09-11

  The invention provides compounds of formula (I): wherein R 1 and R 2 are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.

  本发明提供了式(I)的化合物：其中R1和R2如规范所定义；它们的制备过程；含有它们的制药组合物；制备制药组合物的过程；以及它们在治疗中的应用。这些化合物可用作MMP抑制剂。
• MAURER, F.
  作者：MAURER, F.

  DOI：——

  日期：——
• HYDANTOIN DERIVATIVES USED AS MMP INHIBITORS
  申请人：AstraZeneca AB

  公开号：EP2097406A1

  公开（公告）日：2009-09-09