phenylcarbamoyloxyamine hydrochloride | 60506-42-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenylcarbamoyloxyamine hydrochloride
• 英文别名: O-Phenylcarbamoyl-hydroxylamin；amino N-phenylcarbamate
• CAS: 60506-42-5
• 化学式: C₇H₈N₂O₂
• 分子量: 152.153
• InChiKey: YQHOHPOCZUAUKP-UHFFFAOYSA-N

物化性质

• 熔点：
  250-251 °C
• 密度：
  1.311±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phenylcarbamoyloxyamine hydrochloride 、 丙酮 在 magnesium sulfate 、 溶剂黄146 作用下， 生成 2-丙酮 O-[(苯基氨基)羰基]肟
  参考文献：
  名称：

  具有 (E) - 和 (Z) - 乙酰羟肟酸甲酯作为保护功能的 O-酰基羟胺的表示

  摘要：

  标题化合物 1 的 (E) 和 (Z) 形式同样适合作为制备 N-未取代的 O-酰基羟胺 3 的保护功能：将酯用酰氯、氯甲酸酯和异氰酸酯酰化后，它们可以通过标准化的酸解独立于配置去除。

  DOI：

  10.1002/ardp.19783110614
• 作为产物：
  描述：

  phenylcarbamic acid chloride 在 盐酸 、 三乙胺 作用下， 生成 phenylcarbamoyloxyamine hydrochloride
  参考文献：
  名称：

  关于进一步的 N-未取代的 O-酰基-羟胺 41. 关于羟胺衍生物的交流

  摘要：

  通过 O-酰化乙酰羟肟酯的水解和通过 HCl 裂解，O-酰化叔。丁基-N-羟基氨基甲酸酯可用于制备其他O-酰基-羟胺，包括具有烷氧基羰基和单和二取代氨基甲酰基的那些。

  DOI：

  10.1002/ardp.19703030405

文献信息

• PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ITCH
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1547616A1

  公开（公告）日：2005-06-29

  The present invention provides an agent for prevention and/or treatment of itching comprising a substance capable of suppressing the function involved in signal transduction of GPR4 as an active ingredient. It also provides a nitrogen-containing tricyclic compound represented by the formula (I) or a quaternary ammonium salt thereof, or a pharmaceutically acceptable salt thereof; [wherein R1 represents substituted or unsubstituted lower alkyl, etc.; R2 represents hydrogen, substituted or unsubstituted lower alkyl, etc.; R3 and R4 are the same or different and each represents hydrogen, lower alkyl, etc.; n represents 0 or 1; X represents -(CH2)2-, etc.; and Y represents the formula (II); (wherein W represents CH or a nitrogen atom; Z1 and Z2 are the same or different and each represents hydrogen, substituted or unsubstituted lower alkyl, etc.; and Z3 represents hydrogen, substituted or unsubstituted lower alkyl, etc.)]

  本发明提供了一种用于预防和/或治疗瘙痒的药剂，包括一种能够抑制参与GPR4信号转导功能的物质作为活性成分。它还提供了一种由式（I）表示的含氮三环化合物或其季铵盐，或其药用可接受盐；[其中R1代表取代或未取代的较低烷基等；R2代表氢、取代或未取代的较低烷基等；R3和R4相同或不同，各自代表氢、较低烷基等；n代表0或1；X代表-(CH2)2-等；Y代表式（II）；（其中W代表CH或氮原子；Z1和Z2相同或不同，各自代表氢、取代或未取代的较低烷基等；Z3代表氢、取代或未取代的较低烷基等）]
• Preventive and/or therapeutic drugs for asthma
  申请人：Saki Mayumi

  公开号：US20060239999A1

  公开（公告）日：2006-10-26

  The present invention provides an agent for prevention and/or treatment of asthma comprising a substance capable of suppressing the function involved in signal transduction of GPR4 as an active ingredient. It also provides an agent for prevention and/or treatment of asthma which comprises a nitrogen-containing tricyclic compound represented by the formula (I) or a quaternary ammonium salt thereof, or a pharmaceutically acceptable salt thereof; [wherein R 1 represents a substituted or unsubstituted lower alkyl, or the like; R 2 represents hydrogen, a substituted or unsubstituted lower alkyl, or the like; R 3 and R 4 are the same or different and each represents hydrogen, lower alkyl, or the like; n represents 0 or 1; X represents —(CH 2 ) 2 —, or the like; and Y represents the formula (II) (wherein W represents CH or a nitrogen atom; Z 1 and Z 2 are the same or different and each represents hydrogen, a substituted or unsubstituted lower alkyl, or the like; and Z 3 represents hydrogen, a substituted or unsubstituted lower alkyl, or the like)] as an active ingredient.

  本发明提供了一种用于预防和/或治疗哮喘的药剂，其包括一种能够抑制GPR4信号转导功能的物质作为活性成分。还提供了一种用于预防和/或治疗哮喘的药剂，其包括式(I)所表示的含氮三环化合物或其季铵盐，或其药学上可接受的盐；[其中R1表示取代或未取代的低碳基等；R2表示氢、取代或未取代的低碳基等；R3和R4相同或不同，每个表示氢、低碳基等；n表示0或1；X表示—(CH2)2—等；Y表示式(II)（其中W表示CH或氮原子；Z1和Z2相同或不同，每个表示氢、取代或未取代的低碳基等；Z3表示氢、取代或未取代的低碳基等）]作为活性成分。
• Preventive and/or trerapeutic drgs for itch
  申请人：Saki Mayumi

  公开号：US20060252679A1

  公开（公告）日：2006-11-09

  The present invention provides an agent for prevention and/or treatment of itching comprising a substance capable of suppressing the function involved in signal transduction of GPR4 as an active ingredient. It also provides a nitrogen-containing tricyclic compound represented by the formula (I) or a quaternary ammonium salt thereof, or a pharmaceutically acceptable salt thereof; [wherein R 1 represents substituted or unsubstituted lower alkyl, etc.; R 2 represents hydrogen, substituted or unsubstituted lower alkyl, etc.; R 3 and R 4 are the same or different and each represents hydrogen, lower alkyl, etc.; n represents 0 or 1; X represents —(CH 2 ) 2 —, etc.; and Y represents the formula (II); (wherein W represents CH or a nitrogen atom; Z 1 and Z 2 are the same or different and each represents hydrogen, substituted or unsubstituted lower alkyl, etc.; and Z 3 represents hydrogen, substituted or unsubstituted lower alkyl, etc.)]

  本发明提供了一种用于预防和/或治疗瘙痒的药剂，其包括一种能够抑制GPR4信号传导功能的物质作为活性成分。它还提供了一种氮杂三环化合物，其表示为式(I)或其季铵盐，或其药学上可接受的盐；其中，R1表示取代或未取代的低碳基等；R2表示氢，取代或未取代的低碳基等；R3和R4相同或不同，每个表示氢，低碳基等；n表示0或1；X表示—(CH2)2—等；Y表示式(II)；(其中，W表示CH或氮原子；Z1和Z2相同或不同，每个表示氢，取代或未取代的低碳基等；Z3表示氢，取代或未取代的低碳基等。)
• PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ASTHMA
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1537879A1

  公开（公告）日：2005-06-08

  The present invention provides an agent for prevention and/or treatment of asthma comprising a substance capable of suppressing the function involved in signal transduction of GPR4 as an active ingredient. It also provides an agent for prevention and/or treatment of asthma which comprises a nitrogen-containing tricyclic compound represented by the formula (I) or a quaternary ammonium salt thereof, or a pharmaceutically acceptable salt thereof; [wherein R1 represents a substituted or unsubstituted lower alkyl, or the like; R2 represents hydrogen, a substituted or unsubstituted lower alkyl, or the like; R3 and R4 are the same or different and each represents hydrogen, lower alkyl, or the like; n represents 0 or 1; X represents -(CH2)2-, or the like; and Y represents the formula (II) (wherein W represents CH or a nitrogen atom; Z1 and Z2 are the same or different and each represents hydrogen, a substituted or unsubstituted lower alkyl, or the like; and Z3 represents hydrogen, a substituted or unsubstituted lower alkyl, or the like)] as an active ingredient.

  本发明提供了一种用于预防和/或治疗哮喘的制剂，其活性成分包括一种能够抑制参与 GPR4 信号转导功能的物质。本发明还提供了一种用于预防和/或治疗哮喘的制剂，该制剂包含由式（I）代表的含氮三环化合物或其季铵盐，或其药学上可接受的盐； [其中 R1 代表取代或未取代的低级烷基或类似物；R2 代表氢、取代或未取代的低级烷基或类似物；R3 和 R4 相同或不同，各自代表氢、低级烷基或类似物；n 代表 0 或 1；X 代表-(CH2)2- 或类似物；Y 代表式 (II) (其中 W 代表 CH 或氮原子；Z1 和 Z2 相同或不同，各自代表氢、取代或未取代的低级烷基或类似物；Z3 代表氢、取代或未取代的低级烷基或类似物）]作为活性成分。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。