{2-[(2-Oxo-2H-chromene-3-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester | 287401-64-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: {2-[(2-Oxo-2H-chromene-3-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[2-[(2-oxochromene-3-carbonyl)amino]ethyl]carbamate
• CAS: 287401-64-3
• 化学式: C₁₇H₂₀N₂O₅
• 分子量: 332.356
• InChiKey: QGKMSUAGNAVTJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  93.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  {2-[(2-Oxo-2H-chromene-3-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 25.0h， 生成
  参考文献：
  名称：

  一种双乙烯磺酰胺连接子及其制备和应用

  摘要：

  本发明提供了一种双乙烯磺酰胺连接子及其制备和应用。所述的双乙烯磺酰胺连接子的结构式为式I或式II。本发明提供的新型双乙烯磺酰胺连接子不仅一端可以偶联多肽或蛋白，另一端同时可以连接亲和标记物或示踪荧光物质或活性药物。

  公开号：

  CN107400072B
• 作为产物：
  描述：

  香豆素-3-羧酸 、 N-叔丁氧羰基-1,2-乙二胺 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 作用下， 以 乙腈 为溶剂， 生成 {2-[(2-Oxo-2H-chromene-3-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester
  参考文献：
  名称：

  荧光香豆素衍生物的设计和合成及其对 Cu2+ 传感的研究，并在土壤提取物中的应用

  摘要：

  系统地设计、合成和研究了一系列荧光香豆素衍生物 2a-e，以了解它们在水介质中的 Cu2+ 传感性能。开关荧光 Cu2+ 传感信号的灵敏度和选择性与这些香豆素配位部分中杂原子的相对排列直接相关。探针 2b 和 2d 表现出 Cu2+ 浓度依赖性和选择性荧光猝灭，线性范围为 0-80 μM 和 0-10 μM，检测限分别为 0.14 μM 和 0.38 μM。Cu2+ 配位后 2b 的结构变化随后是荧光滴定、衰减全反射傅里叶变换红外光谱 (ATR-FTIR)、质谱和单晶 X 射线衍射对分离的 Cu2+-香豆素复合物。结果显示为 1：

  DOI：

  10.3390/molecules24193569

文献信息

• Phosphorescent Oxygen Sensor with Dendritic Protection and Two-Photon Absorbing Antenna
  作者：Raymond P. Briñas、Thomas Troxler、Robin M. Hochstrasser、Sergei A. Vinogradov

  DOI：10.1021/ja052947c

  日期：2005.8.24

  Imaging oxygen in 3D with submicron spatial resolution can be made possible by combining phosphorescence quenching technique with multiphoton laser scanning microscopy. Because Pt and Pd porphyrin-based phosphorescent dyes, traditionally used as phosphors in biological oxygen measurements, exhibit extremely low two-photon absorption (2PA) cross-sections, we designed a nanosensor for oxygen, in which a 2P absorbing antenna is coupled to a metalloporphyrin core via intramolecular energy transfer (ET) with the purpose of amplifying the 2PA induced phosphorescence of the metalloporphyrin. The central component of the device is a polyfunctionalized Pt porphyrin, whose triplet state emission at ambient temperatures is strong, occurs in the near infrared and is sensitive to O-2. The 2PA chromophores are chosen in such a way that their absorption is maximal in the near infrared (NIR) window of tissue (e.g., 700-900 nm), while their fluorescence is overlapped with the absorption band(s) of the core metalloporphyrin, ensuring an efficient antenna-core resonance ET. The metalloporphyrin-antenna construct is embedded inside the protecting dendritic jacket, which isolates the core from interactions with biological macromolecules, controls diffusion of oxygen and makes the entire sensor water-soluble. Several Pt porphyrin-cournarin based sensors were synthesized and their photophyics studied to evaluate the proposed design.
• Synthesis and Fluorescence Properties of New Fluorescent, Polymerizable, Metal-Chelating Lipids
  作者：Bidhan C. Roy、Rachel Peterson、Sanku Mallik、Andres D. Campiglia

  DOI：10.1021/jo991836r

  日期：2000.6.1

  Liposomes incorporating fluorescent, metal-chelating lipids find applications in molecular recognition of peptides, 2D protein recystallization, protein targeting, and biological sensing. It would be advantageous to combine the usefulness of polymerizable, metal-chelating lipids and fluorescent lipids. Herein, we report the synthesis and fluorescence properties of several fluorescent, polymerizable, metal-chelating lipids. They have been successfully incorporated into liposomes and then polymerized. These lipids can be used as membrane probes to study the polymerizable liposomes in the unpolymerized state and to investigate lipid redistribution during polymerization. In addition, if a luminescent metal ion (e.g., Eu3+, Tb3+, etc.) is used to complex the headgroup, the lipids can probe the membrane interior and exterior simultaneously.
• 一种双乙烯磺酰胺连接子及其制备和应用
  申请人：上海科技大学

  公开号：CN107400072B

  公开（公告）日：2021-02-05

  本发明提供了一种双乙烯磺酰胺连接子及其制备和应用。所述的双乙烯磺酰胺连接子的结构式为式I或式II。本发明提供的新型双乙烯磺酰胺连接子不仅一端可以偶联多肽或蛋白，另一端同时可以连接亲和标记物或示踪荧光物质或活性药物。
• The Design and Synthesis of Fluorescent Coumarin Derivatives and Their Study for Cu2+ Sensing with an Application for Aqueous Soil Extracts
  作者：Qian、Váradi、Trinchi、Reichman、Bao、Lan、Wei、Cole

  DOI：10.3390/molecules24193569

  日期：——

  designed, synthesized and studied for their Cu2+ sensing performance in aqueous media. The sensitivities and selectivities of the on-to-off fluorescent Cu2+ sensing signal were in direct correlation with the relative arrangements of the heteroatoms within the coordinating moieties of these coumarins. Probes 2b and 2d exhibited Cu2+ concentration dependent and selective fluorescence quenching, with linear ranges

  系统地设计、合成和研究了一系列荧光香豆素衍生物 2a-e，以了解它们在水介质中的 Cu2+ 传感性能。开关荧光 Cu2+ 传感信号的灵敏度和选择性与这些香豆素配位部分中杂原子的相对排列直接相关。探针 2b 和 2d 表现出 Cu2+ 浓度依赖性和选择性荧光猝灭，线性范围为 0-80 μM 和 0-10 μM，检测限分别为 0.14 μM 和 0.38 μM。Cu2+ 配位后 2b 的结构变化随后是荧光滴定、衰减全反射傅里叶变换红外光谱 (ATR-FTIR)、质谱和单晶 X 射线衍射对分离的 Cu2+-香豆素复合物。结果显示为 1：