N-(2-aminoethyl)-2-oxo-2H-chromene-3-carboxamide | 287401-65-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: N-(2-aminoethyl)-2-oxo-2H-chromene-3-carboxamide
• 英文别名: N-(2-aminoethyl)-2-oxa-2H-benzopyran-3-carboxamide；3-Carboxamido coumarin, 5；N-(2-aminoethyl)-2-oxochromene-3-carboxamide
• CAS: 287401-65-4
• 化学式: C₁₂H₁₂N₂O₃
• mdl: MFCD00600433
• 分子量: 232.239
• InChiKey: ZZZHRZHNTZJEMF-UHFFFAOYSA-N

物化性质

• 沸点：
  536.3±50.0 °C(Predicted)
• 密度：
  1.324±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(2-aminoethyl)-2-oxo-2H-chromene-3-carboxamide 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.5h， 生成
  参考文献：
  名称：

  一种双乙烯磺酰胺连接子及其制备和应用

  摘要：

  本发明提供了一种双乙烯磺酰胺连接子及其制备和应用。所述的双乙烯磺酰胺连接子的结构式为式I或式II。本发明提供的新型双乙烯磺酰胺连接子不仅一端可以偶联多肽或蛋白，另一端同时可以连接亲和标记物或示踪荧光物质或活性药物。

  公开号：

  CN107400072B
• 作为产物：
  描述：

  {2-[(2-Oxo-2H-chromene-3-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester 在 三氟乙酸 作用下， 反应 2.0h， 以30%的产率得到N-(2-aminoethyl)-2-oxo-2H-chromene-3-carboxamide
  参考文献：
  名称：

  荧光香豆素衍生物的设计和合成及其对 Cu2+ 传感的研究，并在土壤提取物中的应用

  摘要：

  系统地设计、合成和研究了一系列荧光香豆素衍生物 2a-e，以了解它们在水介质中的 Cu2+ 传感性能。开关荧光 Cu2+ 传感信号的灵敏度和选择性与这些香豆素配位部分中杂原子的相对排列直接相关。探针 2b 和 2d 表现出 Cu2+ 浓度依赖性和选择性荧光猝灭，线性范围为 0-80 μM 和 0-10 μM，检测限分别为 0.14 μM 和 0.38 μM。Cu2+ 配位后 2b 的结构变化随后是荧光滴定、衰减全反射傅里叶变换红外光谱 (ATR-FTIR)、质谱和单晶 X 射线衍射对分离的 Cu2+-香豆素复合物。结果显示为 1：

  DOI：

  10.3390/molecules24193569

文献信息

• 一种三氟甲磺酰基炔酰胺类化合物及其制备方法和用途
  申请人：江西师范大学

  公开号：CN112979509B

  公开（公告）日：2022-04-22

  本发明公开了一种三氟甲磺酰基炔酰胺类化合物及其制备方法和用途。基于该类炔酰胺与巯基的硫氢化反应，进而实现对多肽与蛋白质中的巯基进行选择性修饰与标记。该类化合物具有较好的稳定性。还可以选择性的只和巯基反应，而多肽或蛋白质上的其他活性基团不受影响；具有反应速率快、无副反应、反应条件简单温和、易操作、底物适用性广和原子经济性高等优点。其在酸碱、氧化条件下都具有良好的稳定性，并且可以在常温下稳定存在数月，为生物偶联、多肽和/或蛋白质中的巯基进行选择性修饰与标记提供了新的稳健途径。
• Phosphorescent Oxygen Sensor with Dendritic Protection and Two-Photon Absorbing Antenna
  作者：Raymond P. Briñas、Thomas Troxler、Robin M. Hochstrasser、Sergei A. Vinogradov

  DOI：10.1021/ja052947c

  日期：2005.8.24

  Imaging oxygen in 3D with submicron spatial resolution can be made possible by combining phosphorescence quenching technique with multiphoton laser scanning microscopy. Because Pt and Pd porphyrin-based phosphorescent dyes, traditionally used as phosphors in biological oxygen measurements, exhibit extremely low two-photon absorption (2PA) cross-sections, we designed a nanosensor for oxygen, in which a 2P absorbing antenna is coupled to a metalloporphyrin core via intramolecular energy transfer (ET) with the purpose of amplifying the 2PA induced phosphorescence of the metalloporphyrin. The central component of the device is a polyfunctionalized Pt porphyrin, whose triplet state emission at ambient temperatures is strong, occurs in the near infrared and is sensitive to O-2. The 2PA chromophores are chosen in such a way that their absorption is maximal in the near infrared (NIR) window of tissue (e.g., 700-900 nm), while their fluorescence is overlapped with the absorption band(s) of the core metalloporphyrin, ensuring an efficient antenna-core resonance ET. The metalloporphyrin-antenna construct is embedded inside the protecting dendritic jacket, which isolates the core from interactions with biological macromolecules, controls diffusion of oxygen and makes the entire sensor water-soluble. Several Pt porphyrin-cournarin based sensors were synthesized and their photophyics studied to evaluate the proposed design.
• Synthesis and Fluorescence Properties of New Fluorescent, Polymerizable, Metal-Chelating Lipids
  作者：Bidhan C. Roy、Rachel Peterson、Sanku Mallik、Andres D. Campiglia

  DOI：10.1021/jo991836r

  日期：2000.6.1

  Liposomes incorporating fluorescent, metal-chelating lipids find applications in molecular recognition of peptides, 2D protein recystallization, protein targeting, and biological sensing. It would be advantageous to combine the usefulness of polymerizable, metal-chelating lipids and fluorescent lipids. Herein, we report the synthesis and fluorescence properties of several fluorescent, polymerizable, metal-chelating lipids. They have been successfully incorporated into liposomes and then polymerized. These lipids can be used as membrane probes to study the polymerizable liposomes in the unpolymerized state and to investigate lipid redistribution during polymerization. In addition, if a luminescent metal ion (e.g., Eu3+, Tb3+, etc.) is used to complex the headgroup, the lipids can probe the membrane interior and exterior simultaneously.
• HAPTENS, HAPTEN CONJUGATES, COMPOSITIONS THEREOF AND METHOD FOR THEIR PREPARATION AND USE
  申请人：Ventana Medical Systems, Inc.

  公开号：EP3029461B1

  公开（公告）日：2017-12-20
• [EN] ANTIOXIDANT SMALL MOLECULES AIMED AT TARGETING METAL-BASED OXIDATIVE STRESS IN NEURODEGNERATIVE DISORDERS<br/>[FR] PETITES MOLÉCULES ANTIOXYDANTES DESTINÉES À CIBLER LE STRESS OXYDATIF INDUIT PAR LES MÉTAUX DANS LES TROUBLES NEURODÉGÉNÉRATIFS
  申请人：TEXAS CHRISTIAN UNIVERSITY

  公开号：WO2014113624A1

  公开（公告）日：2014-07-24

  Amine chelates capable of antioxidant capacity and amyloid disaggregation are shown which may be useful in targeting metal-based oxidative stress in neurodegenerative disorders. Pyclen, a backbone commonly investigated for contrast agent imaging, may be repurposed as an anti-oxidant chelator for disaggregating amyloid. The antioxidant capacity of pyclen is enhanced dramatically via conversion of the pyridine backbone to a pyridol with cellular studies showing superior antioxidant capacity while retaining chelation ability to protect amyloid from metal ions aggregation and also disaggregate amyloid aggregates. Another family of molecules based upon hybrid heterocyclic amine ligands is also presented.