1-{4-[2-(2-methoxyethoxy)ethoxy]phenyl}-ethan-1-ol | 618100-62-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-{4-[2-(2-methoxyethoxy)ethoxy]phenyl}-ethan-1-ol
• 英文别名: 1-[4-[2-(2-Methoxyethoxy)ethoxy]phenyl]ethanol
• CAS: 618100-62-2
• 化学式: C₁₃H₂₀O₄
• mdl: MFCD19588368
• 分子量: 240.299
• InChiKey: CQIOXLKSIAORDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-{4-[2-(2-methoxyethoxy)ethoxy]phenyl}-ethan-1-ol 在 4-甲基苯磺酸吡啶 作用下， 以 甲苯 为溶剂， 以95%的产率得到1-(2-(2-methoxyethoxy)ethoxy)-4-vinylbenzene
  参考文献：
  名称：

  Improving resins for solid phase synthesis: incorporation of 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene

  摘要：

  The preparation, characterisation and application of a series of non-grafted polystyrene (PS) resins containing a styrenic methoxypoly(ethylene glycol) (MPEG) derivative is presented. These novel PS-MPEG resins were designed to balance swelling and solvation with improved handling. The monomer, 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene, contained an inert phenyl ether linkage designed to provide broad chemical compatibility and stability, yet imparting all the favourable properties of the PEG group into the new resin, whilst maintaining a high loading capacity. The synthetic performance of the new resins compared very favourably to those of TentaGel(TM), ArgoGel(TM) and aminomethyl PS. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(03)01100-1
• 作为产物：
  描述：

  二乙二醇单甲醚 在 sodium tetrahydroborate 、 potassium carbonate 、 三乙胺 、 potassium iodide 作用下， 以 四氢呋喃 、 乙醇 、 乙腈 为溶剂， 反应 51.0h， 生成 1-{4-[2-(2-methoxyethoxy)ethoxy]phenyl}-ethan-1-ol
  参考文献：
  名称：

  Improving resins for solid phase synthesis: incorporation of 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene

  摘要：

  The preparation, characterisation and application of a series of non-grafted polystyrene (PS) resins containing a styrenic methoxypoly(ethylene glycol) (MPEG) derivative is presented. These novel PS-MPEG resins were designed to balance swelling and solvation with improved handling. The monomer, 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene, contained an inert phenyl ether linkage designed to provide broad chemical compatibility and stability, yet imparting all the favourable properties of the PEG group into the new resin, whilst maintaining a high loading capacity. The synthetic performance of the new resins compared very favourably to those of TentaGel(TM), ArgoGel(TM) and aminomethyl PS. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(03)01100-1

文献信息

• Improving resins for solid phase synthesis: incorporation of 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene
  作者：Sonia M Alesso、Zhanru Yu、David Pears、Paul A Worthington、Richard W.A Luke、Mark Bradley

  DOI：10.1016/s0040-4020(03)01100-1

  日期：2003.9

  The preparation, characterisation and application of a series of non-grafted polystyrene (PS) resins containing a styrenic methoxypoly(ethylene glycol) (MPEG) derivative is presented. These novel PS-MPEG resins were designed to balance swelling and solvation with improved handling. The monomer, 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene, contained an inert phenyl ether linkage designed to provide broad chemical compatibility and stability, yet imparting all the favourable properties of the PEG group into the new resin, whilst maintaining a high loading capacity. The synthetic performance of the new resins compared very favourably to those of TentaGel(TM), ArgoGel(TM) and aminomethyl PS. (C) 2003 Elsevier Ltd. All rights reserved.