2-乙氧基-1,3-二甲氧基-5-硝基苯 | 189564-60-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-乙氧基-1,3-二甲氧基-5-硝基苯
• 英文名称: 3,5-dimethoxy-4-ethoxynitrobenzene
• 英文别名: 2-Ethoxy-1,3-dimethoxy-5-nitrobenzene
• CAS: 189564-60-1
• 化学式: C₁₀H₁₃NO₅
• 分子量: 227.217
• InChiKey: OHDURDXCCGUNOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  73.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-乙氧基-1,3-二甲氧基-5-硝基苯 在 palladium on activated charcoal 氢气 作用下， 生成 4-ethoxy-3,5-dimethoxy-aniline
  参考文献：
  名称：

  Inhibitors of Src tyrosine kinase: the preparation and structure–activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines

  摘要：

  Src is a nonreceptor tyrosine kinase involved in signaling pathways that control proliferation, migration, and angiogenesis. Increased Src expression and activity are associated with an increase in tumor malignancy and poor prognosis. Several quinolines and quinazolines were identified as potent and selective inhibitors of Src kinase activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00493-5
• 作为产物：
  描述：

  乙醇 、 1,2,3-三甲氧基-5-硝基苯 在 sodium hydride 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.92h， 以96%的产率得到2-乙氧基-1,3-二甲氧基-5-硝基苯
  参考文献：
  名称：

  Inhibitors of Src tyrosine kinase: the preparation and structure–activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines

  摘要：

  Src is a nonreceptor tyrosine kinase involved in signaling pathways that control proliferation, migration, and angiogenesis. Increased Src expression and activity are associated with an increase in tumor malignancy and poor prognosis. Several quinolines and quinazolines were identified as potent and selective inhibitors of Src kinase activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00493-5

文献信息

• PYRIMIDINE DERIVATIVES AS 5HT2C RECEPTOR ANTAGONISTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0856001B1

  公开（公告）日：2002-08-28
• PYRIMIDINE DERIVATIVES AS 5HT 2C?-RECEPTOR ANTAGONISTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0856001A1

  公开（公告）日：1998-08-05
• US5753663A
  申请人：——

  公开号：US5753663A

  公开（公告）日：1998-05-19
• [EN] PYRIMIDINE DERIVATIVES AS 5HT2C-RECEPTOR ANTAGONISTS<br/>[FR] DERIVES DE PYRIMIDINE EN TANT QU'ANTAGONISTES DU RECEPTEUR DE 5HT2C
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：WO1997012880A1

  公开（公告）日：1997-04-10

  (EN) The disclosed pyrimidine derivatives, and pharmaceutically acceptable salts thereof, exhibit useful pharmacological properties, in particular use as 5HT2C-receptor antagonists. The invention is also directed to formulations and methods for treatment.(FR) Les dérivés de pyrimidine décrits, et leurs sels, acceptables sur le plan pharmaceutique, démontrent des propriétés pharmacologiques utiles, notamment en tant qu'antagonistes du récepteur de 5HT2C. L'invention concerne également des formulations et procédés de traitement.
• Inhibitors of Src tyrosine kinase: the preparation and structure–activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines
  作者：Yanong D. Wang、Karen Miller、Diane H. Boschelli、Fei Ye、Biqi Wu、M.Brawner Floyd、Dennis W. Powell、Allan Wissner、Jennifer M. Weber、Frank Boschelli

  DOI：10.1016/s0960-894x(00)00493-5

  日期：2000.11

  Src is a nonreceptor tyrosine kinase involved in signaling pathways that control proliferation, migration, and angiogenesis. Increased Src expression and activity are associated with an increase in tumor malignancy and poor prognosis. Several quinolines and quinazolines were identified as potent and selective inhibitors of Src kinase activity. (C) 2000 Elsevier Science Ltd. All rights reserved.