trans-4-(2′,4′,5′-trimethoxyphenyl)but-3-ene | 76252-27-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: trans-4-(2′,4′,5′-trimethoxyphenyl)but-3-ene
• 英文别名: (E)-5-(1-butenyl)-1,2,4-trimethoxybenzene；(E)-1-(2,4,5-trimethoxyphenyl)-1-butene；(E)-1-(2,4,5-trimethoxyphenyl)but-1-ene；1-[(E)-but-1-enyl]-2,4,5-trimethoxybenzene
• CAS: 76252-27-2
• 化学式: C₁₃H₁₈O₃
• 分子量: 222.284
• InChiKey: RWYFPZNSBWWHEI-VOTSOKGWSA-N

物化性质

• 沸点：
  336.8±37.0 °C(Predicted)
• 密度：
  1.015±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,2,4-三甲氧基苯 在 sodium tetrahydroborate 、 三氯化铝 、 硫酸 作用下， 以 1,4-二氧六环 、 甲醇 、 二硫化碳 为溶剂， 反应 1.0h， 生成 trans-4-(2′,4′,5′-trimethoxyphenyl)but-3-ene
  参考文献：
  名称：

  Further characterization of the constituents of a thai medicinal plant, Zingiber cassumunar Roxb.

  摘要：

  从泰国药用植物姜黄（Zingiber cassumunar）的根茎中分离出了13种芳香化合物，这些化合物具有C6-C4、C6-C8-C6或C6-C10的碳骨架。其中8种化合物为新化合物，其结构通过化学和光谱方法被阐明为6、7、8、9、10、11、12和13。其结构通过13C-NMR光谱法得到了确认。

  DOI：

  10.1248/cpb.28.2948

文献信息

• An Effective System to Synthesize Hypolipidemic Active α-Asarone and Related Methoxylated (<i>E</i>)-Arylalkenes
  作者：Anuj Sharma、Bhupendra P. Joshi、Arun K. Sinha

  DOI：10.1246/bcsj.77.2231

  日期：2004.12

  Methoxylated (E)-arylalkenes (1a–1k) were prepared in two steps by an improved Grignard reaction comprising the reverse addition of alkylmagnesium bromide to benzaldehydes (2a–2k) in anhydrous ether and toluene into arylalkanols (3a–3k) in high yield, followed by dehydration with silica gel under microwave irradiation for 3–12 min, depending upon the substituents attached to the aromatic ring to afford hypolipidemic active α-asarone (1a) and related methoxylated (E)-arylalkenes (1b–1k).

  通过改进的Grignard反应，分两步制备了甲氧基化（E）-芳基烯烃（1a-1k）。该反应包括在无水乙醚和甲苯中反向加成烷基镁溴化物至苯甲醛（2a-2k），高产率地转化为芳基醇（3a-3k），随后在微波辐射下，根据芳香环上取代基的不同，利用硅胶进行脱水处理3-12分钟，得到具有降脂活性的α-细辛素（1a）及相关甲氧基化（E）-芳基烯烃（1b-1k）。
• Further characterization of the constituents of a thai medicinal plant, Zingiber cassumunar Roxb.
  作者：MASANORI KUROYANAGI、SEIGO FUKUSHIMA、KUNITOSHI YOSHIHIRA、SHINSAKU NATORI、THAWEEPHOL DECHATIWONGSE、KUNIHIDE MIHASHI、MASATOSHI NISHI、SHUUJI HARA

  DOI：10.1248/cpb.28.2948

  日期：——

  Thirteen aromatic compounds, having C6-C4, C6-C8-C6 or C6-C10 carbon skeletons, were isolated from the rhizomes of a Thai medicinal plant, Zingiber cassumunar. Eight compounds were new among these, and their structures were elucidated as 6, 7, 8, 9, 10, 11, 12, and 13 by chemical and spectral methods. The structures were confirmed by 13C-NMR spectroscopy.

  从泰国药用植物姜黄（Zingiber cassumunar）的根茎中分离出了13种芳香化合物，这些化合物具有C6-C4、C6-C8-C6或C6-C10的碳骨架。其中8种化合物为新化合物，其结构通过化学和光谱方法被阐明为6、7、8、9、10、11、12和13。其结构通过13C-NMR光谱法得到了确认。
• TRIPEPTIDE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
  申请人：NORTHWEST UNIVERSITY

  公开号：US20170267718A1

  公开（公告）日：2017-09-21

  Provided are a tripeptide compound, a preparation method therefor, and an application thereof. The structure of the related compound is represented by formula (I). The provided compound has angiotensin converting enzyme inhibiting bioactivity, and the compound and a pharmaceutical composition thereof play a role in preventing and treating hypertension and other cardiocerebral vascular system diseases.

  提供了一种三肽化合物，其制备方法和应用。相关化合物的结构由式（I）表示。提供的化合物具有抑制血管紧张素转换酶的生物活性，该化合物及其药物组成对预防和治疗高血压和其他心脑血管系统疾病起着作用。
• a-ASARY-LALDEHYDE ESTER, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
  申请人：NORTHWEST UNIVERSITY

  公开号：US20170260122A1

  公开（公告）日：2017-09-14

  The present invention relates to α-asary-laldehyde ester, a preparation method therefor, and an application thereof. The chemical structure of the related α-asary-laldehyde ester is represented by formula I. A related application is an application of the compound in preparation of drugs for calming, mind tranquillizing, senile dementia resisting, convulsion resisting, epilepsy resisting and depression resisting.

  本发明涉及α-沙尼醛酯、其制备方法及其应用。相关α-沙尼醛酯的化学结构由式I表示。相关应用是将该化合物用于制备镇静、安神、抗老年性痴呆、抗惊厥、抗癫痫和抗抑郁药物。
• Ultrasound-assisted convenient synthesis of hypolipidemic active natural methoxylated (E)-arylalkenes and arylalkanones
  作者：Bhupendra P. Joshi、Anuj Sharma、Arun K. Sinha

  DOI：10.1016/j.tet.2005.01.071

  日期：2005.3

  An ultrasound-assisted convenient method was developed for the conversion of toxic methoxylated cis-isomer of arylalkenes into its hypolipidemic active trans-isomer. Treatment of cis-isomer or mixture of all three isomers (1a-1j) with ammonium formate and 10% Pd/C gave arylalkanes (2a-2j), which upon oxidation with DDQ in anhydrous dioxane containing a little amount of silica gel, provided (E)-arylalkenes (3a-3g) in 42-72% yield depending upon the substituents attached at the aryl ring. The same method, upon addition of a few drops of water, provided hypolipidemic active arylalkanones (3h-3j) in 59-65% yield. (c) 2005 Elsevier Ltd. All rights reserved.