diethyl 4-(1'-trimethylsilylmethylenecyclopropyl)butane-1,1-dicarboxylate | 166879-26-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: diethyl 4-(1'-trimethylsilylmethylenecyclopropyl)butane-1,1-dicarboxylate
• 英文别名: Diethyl 2-[3-(2-methylidene-1-trimethylsilylcyclopropyl)propyl]propanedioate
• CAS: 166879-26-1
• 化学式: C₁₇H₃₀O₄Si
• 分子量: 326.508
• InChiKey: FQKUGLMBFSJRJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.94
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diethyl 4-(1'-trimethylsilylmethylenecyclopropyl)butane-1,1-dicarboxylate 在 N-碘代丁二酰亚胺 、 六正丁基二锡 、 potassium hydride 作用下， 以 甲苯 为溶剂， 反应 4.17h， 生成 diethyl 1-iodo-7-trimethylsilylbicyclo<5.1.0>octane 3,3-dicarboxylate
  参考文献：
  名称：

  Malonate radical cyclisations of methylenecyclopropane derivatives

  摘要：

  Cyclisations of various methylenecyclopropyl substituted malonate radicals have been studied. Radicals derived from malonates 4 and 9 underwent exclusive 5-exo cyclisation onto the methylenecyclopropane alkene, followed by opening of the resulting cyclopropylmethyl radical, to give methylenecyclohexane products. Radicals derived from malonates 5 and 10 largely gave bicyclo[1.5.0]octane products, in good yields, as a result of 7-endo cyclisation. Cyclisation of the radical derived from malonate 11 gave a bicyclo[1.5.0]nonane derivative in 31% yield, as a result of an 8-endo cyclisation.

  DOI：

  10.1016/s0040-4020(01)89430-8
• 作为产物：
  描述：

  1-bromo-3-(1'-trimethylsilylmethylenecyclopropyl)propane 、 丙二酸二乙酯 在 sodium hydride 作用下， 生成 diethyl 4-(1'-trimethylsilylmethylenecyclopropyl)butane-1,1-dicarboxylate
  参考文献：
  名称：

  Malonate radical cyclisations of methylenecyclopropane derivatives

  摘要：

  Cyclisations of various methylenecyclopropyl substituted malonate radicals have been studied. Radicals derived from malonates 4 and 9 underwent exclusive 5-exo cyclisation onto the methylenecyclopropane alkene, followed by opening of the resulting cyclopropylmethyl radical, to give methylenecyclohexane products. Radicals derived from malonates 5 and 10 largely gave bicyclo[1.5.0]octane products, in good yields, as a result of 7-endo cyclisation. Cyclisation of the radical derived from malonate 11 gave a bicyclo[1.5.0]nonane derivative in 31% yield, as a result of an 8-endo cyclisation.

  DOI：

  10.1016/s0040-4020(01)89430-8

文献信息

• Destabel Christine, Kilburn Jeremy D., Knight John, Tetrahedron, 50 (1994) N 38, S 11289-11302
  作者：Destabel Christine, Kilburn Jeremy D., Knight John

  DOI：——

  日期：——
• Malonate radical cyclisations of methylenecyclopropane derivatives
  作者：Christine Destabel、Jeremy D Kilburn、John Knight

  DOI：10.1016/s0040-4020(01)89430-8

  日期：1994.1

  Cyclisations of various methylenecyclopropyl substituted malonate radicals have been studied. Radicals derived from malonates 4 and 9 underwent exclusive 5-exo cyclisation onto the methylenecyclopropane alkene, followed by opening of the resulting cyclopropylmethyl radical, to give methylenecyclohexane products. Radicals derived from malonates 5 and 10 largely gave bicyclo[1.5.0]octane products, in good yields, as a result of 7-endo cyclisation. Cyclisation of the radical derived from malonate 11 gave a bicyclo[1.5.0]nonane derivative in 31% yield, as a result of an 8-endo cyclisation.