tetramethyl methylene-bis-tartronate | 163359-02-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tetramethyl methylene-bis-tartronate
• 英文别名: Tetramethyl methylenebistartronate；tetramethyl 1,3-dihydroxypropane-1,1,3,3-tetracarboxylate
• CAS: 163359-02-2
• 化学式: C₁₁H₁₆O₁₀
• 分子量: 308.242
• InChiKey: AHWMMRFYWKDSQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  146
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  tetramethyl methylene-bis-tartronate 反应 0.25h， 以89%的产率得到2-hydroxy-2,4,4-tris-methoxycarbonyl-γ-butyrolactone
  参考文献：
  名称：

  Autoassembly of cage structures

  摘要：

  Methylene-bis-tartronates and methylene-bis-hydroxymethylmalonates form monolactones where the CO(2)R and OH (or CH2OH) groups are known to be cis-oriented. However, attempts to prepare the corresponding dilactones failed due to the unsufficient proximity of these functional groups. The results have been confirmed by NMR spectra.

  DOI：

  10.1007/bf00696323
• 作为产物：
  描述：

  2-hydroxy-2,4,4-tris-methoxycarbonyl-γ-butyrolactone 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 72.0h， 以90%的产率得到tetramethyl methylene-bis-tartronate
  参考文献：
  名称：

  Autoassembly of cage structures

  摘要：

  Methylene-bis-tartronates and methylene-bis-hydroxymethylmalonates form monolactones where the CO(2)R and OH (or CH2OH) groups are known to be cis-oriented. However, attempts to prepare the corresponding dilactones failed due to the unsufficient proximity of these functional groups. The results have been confirmed by NMR spectra.

  DOI：

  10.1007/bf00696323

文献信息

• Autoassembling of cage structures
  作者：R. G. Kostyanovsky、Yu. I. El'natanov、O. N. Krutius

  DOI：10.1007/bf00700172

  日期：1994.12

  Treatment of alkylenebismalonates with NaH and benzoyl peroxide afforded dibenzoyloxy derivatives. Alkaline hydrolysis of the latter gave alkylenebistartronic acids. Tetramethyl and tetraethyl esters and tetraamides of these acids were synthesized.
• Kostjanowskiii R. G., Elnatanow Ju. I., Krutius O. N., Isw. AN. Ser. khim., (1994) N 12, S 2190-2193
  作者：Kostjanowskiii R. G., Elnatanow Ju. I., Krutius O. N.

  DOI：——

  日期：——
• Autoassembly of cage structures
  作者：R. G. Kostyanovsky、Yu. I. El'natanov、O. N. Krutius、I. I. Chervin

  DOI：10.1007/bf00696323

  日期：1994.11

  Methylene-bis-tartronates and methylene-bis-hydroxymethylmalonates form monolactones where the CO(2)R and OH (or CH2OH) groups are known to be cis-oriented. However, attempts to prepare the corresponding dilactones failed due to the unsufficient proximity of these functional groups. The results have been confirmed by NMR spectra.