bis(p-nitrophenyl) octane-1,8-dioate | 49759-35-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: bis(p-nitrophenyl) octane-1,8-dioate
• 英文别名: di-p-nitrophenyl octanedionate；Korksaeure-bis-<4-nitro-phenylester>；Korksaeure-bis-(4-nitro-phenylester)；Bis(4-nitrophenyl) octanedioate
• CAS: 49759-35-5
• 化学式: C₂₀H₂₀N₂O₈
• 分子量: 416.387
• InChiKey: QPRJCXJSVYJEEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  144
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  bis(p-nitrophenyl) octane-1,8-dioate 在 盐酸 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 octanedioic acid bis-({3-[4-(3-amino-propylamino)-butylamino]-propyl}-amide); compound with GENERIC INORGANIC NEUTRAL COMPONENT
  参考文献：
  名称：

  Synthesis of bis-spermine dimers that are potent polyamine transport inhibitors

  摘要：

  A series of novel spermine dimer analogues was synthesized and assessed for their ability to inhibit spermidine transport into MDA-MB-231 breast carcinoma cells, Two spermine molecules were tethered via their N-1 primary amines with naphthalenedisulfonic acid, adamantanedicarboxylic acid and a series of aliphatic dicarboxylic acids. The linked spermine analogues were potent polyamine transport inhibitors and inhibited cell growth cytostatically in combination with a polyamine synthesis inhibitor. Variation in the linker length did not alter polyamine transport inhibition. The amount of charge on the molecule may influence the molecular interaction with the transporter since the most potent spermidine transport inhibitors contained 5-6 positive charges. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00659-x
• 作为产物：
  描述：

  辛二酸 在 吡啶 、 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 bis(p-nitrophenyl) octane-1,8-dioate
  参考文献：
  名称：

  Uoto, Kouichi; Tomohiro, Takenori; Okuno, Hiroaki (Yohmei), Journal of Heterocyclic Chemistry, 1990, vol. 27, # 4, p. 893 - 897

  摘要：

  DOI：

文献信息

• Molecular transporter compositions comprising dendrimeric oligoguanidine with a tri-functional core that facilitates delivery into cells in vivo
  申请人：Li Yong-Fu

  公开号：US20120035358A1

  公开（公告）日：2012-02-09

  Novel molecular transporter compositions and their use for transporting bioactive substances into cells in living animals are disclosed. To afford in vivo delivery, the composition is covalently linked to the bioactive substance and the resultant composite structure is introduced into the subject. The transporter composition includes multiple guanidine moieties on a dendrimeric scaffold having a tri-functional core. The tri-functional core is a phosphorodiamidate or phosphoramide moiety.

  本发明揭示了新型分子转运体组合物及其用于将生物活性物质运输到活体动物细胞内的方法。为了在体内实现递送，该组合物与生物活性物质共价连接，并将所得的复合结构引入受体体内。转运体组合物包括在三功能核心上具有多个胍基基团的树状支架。三功能核心是磷酸二酰胺或磷酰胺基团。
• Molecular transporter compositions comprising dendrimeric oligoguanidine with a triazine core that facilitate delivery into cells in vivo
  申请人：Li Yong-Fu

  公开号：US20090171075A1

  公开（公告）日：2009-07-02

  Preparations of novel molecular transporter compositions and their use for transporting bioactive substances into cells in living animals are disclosed. To afford in vivo delivery, the composition is covalently linked to the bioactive substance and the resultant composite structure is introduced into the subject. The transporter composition includes multiple guanidine moieties on a dendrimeric scaffold having a triazine core.

  本发明涉及新型分子转运剂组合物的制备及其用于将生物活性物质转运到活体动物细胞中的方法。为了实现体内递送，该组合物与生物活性物质共价连接，并将所得的复合结构引入受体体内。该转运剂组合物包括在三嗪核心的树枝状支架上具有多个胍基基团。
• Stabilization of functional proteins
  申请人：Modrovich, Ivan E.

  公开号：EP0562624A2

  公开（公告）日：1993-09-29

  Labile analytes are stabilized by reaction with a biostabilizer in the presence of a condensing or linking agent.

  在冷凝剂或连接剂存在的情况下，易变分析物通过与生物稳定剂反应而得到稳定。
• Zahn,H.; Schade,F., Chemische Berichte, 1963, vol. 96, p. 1747 - 1750
  作者：Zahn,H.、Schade,F.

  DOI：——

  日期：——
• Okuno, Yohmei; Horita, Kiyoshi; Yonemitsu, Osamu, Journal of the Chemical Society. Perkin transactions I, 1984, # 5, p. 1115 - 1118
  作者：Okuno, Yohmei、Horita, Kiyoshi、Yonemitsu, Osamu、Shibata, Kazue、Amemiya, Toshiyuki、Holm, Richard H.

  DOI：——

  日期：——