Dimethyl 2-[(9,10-dioxoanthracen-2-yl)methyl]propanedioate | 195143-16-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: Dimethyl 2-[(9,10-dioxoanthracen-2-yl)methyl]propanedioate
• 英文别名: dimethyl 2-[(9,10-dioxoanthracen-2-yl)methyl]propanedioate
• CAS: 195143-16-9
• 化学式: C₂₀H₁₆O₆
• 分子量: 352.343
• InChiKey: OUUMDLZCKUIVHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Dimethyl 2-[(9,10-dioxoanthracen-2-yl)methyl]propanedioate 在 sodium hydroxide 、 叠氮磷酸二苯酯 、 水 、 三乙胺 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 85.0h， 生成 2-(2-Aminoethyl)anthracene-9,10-dione
  参考文献：
  名称：

  Amide backbone modifications for antisense oligonucleotides carrying potential intercalating substituents: Influence on the thermodynamic stability of the corresponding duplexes with RNA- and DNA- complements

  摘要：

  The synthesis of the amide dimers 3-5 carrying a potential intercalating substituent on the nitrogen atom of the backbone is presented, together with the incorporation of these modifications into oligonucleotides, the resulting melting temperatures (T-m's) of the corresponding duplexes with RNA- and DNA- complements and a summary of molecular modeling studies. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00318-1
• 作为产物：
  描述：

  2-溴甲基蒽醌 、 丙二酸二甲酯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 以59%的产率得到Dimethyl 2-[(9,10-dioxoanthracen-2-yl)methyl]propanedioate
  参考文献：
  名称：

  Amide backbone modifications for antisense oligonucleotides carrying potential intercalating substituents: Influence on the thermodynamic stability of the corresponding duplexes with RNA- and DNA- complements

  摘要：

  The synthesis of the amide dimers 3-5 carrying a potential intercalating substituent on the nitrogen atom of the backbone is presented, together with the incorporation of these modifications into oligonucleotides, the resulting melting temperatures (T-m's) of the corresponding duplexes with RNA- and DNA- complements and a summary of molecular modeling studies. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00318-1

文献信息

• NOVEL POLYMERIC PHOTOINITIATORS AND PHOTOINITIATOR MONOMERS
  申请人：Coloplast A/S

  公开号：US20150148441A1

  公开（公告）日：2015-05-28

  The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally, there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety, a hydrolytic stable linker and two polymerisable functional groups are incorporated into the photoinitiator structure.

  本发明提供了聚合物光引发剂，其为光引发剂单体与至少一种进一步单体的共聚物，以及作为这种聚合物光引发剂制备过程中的中间体的光引发剂单体。此外，还提供了通过在存在这种聚合物光引发剂的情况下，通过至少一种丙烯酸酯单体（Ac）的自由基聚合得到的聚丙烯酸酯。在光引发剂单体和聚合物光引发剂中，光引发剂基团、水解稳定连接物和两个可聚合功能基团被结合到光引发剂结构中。
• US9296835B2
  申请人：——

  公开号：US9296835B2

  公开（公告）日：2016-03-29
• [EN] NOVEL POLYMERIC PHOTOINITIATORS AND PHOTOINITIATOR MONOMERS<br/>[FR] NOUVEAUX PHOTOINITIATEURS POLYMÈRES ET MONOMÈRES DE PHOTOINITIATEURS
  申请人：COLOPLAST AS

  公开号：WO2013170858A1

  公开（公告）日：2013-11-21

  The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally, there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety, a hydrolytic stable linker and two polymerisable functional groups are incorporated into the photoinitiator structure.
• Amide backbone modifications for antisense oligonucleotides carrying potential intercalating substituents: Influence on the thermodynamic stability of the corresponding duplexes with RNA- and DNA- complements
  作者：Alain De Mesmaeker、Sebastian Wendeborn、Chantal Jouanno、Valérie Fritsch、Romain M. Wolf

  DOI：10.1016/s0960-894x(97)00318-1

  日期：1997.7

  The synthesis of the amide dimers 3-5 carrying a potential intercalating substituent on the nitrogen atom of the backbone is presented, together with the incorporation of these modifications into oligonucleotides, the resulting melting temperatures (T-m's) of the corresponding duplexes with RNA- and DNA- complements and a summary of molecular modeling studies. (C) 1997 Elsevier Science Ltd.