3-(9,10-Dioxoanthracen-2-yl)propanal | 82203-76-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 3-(9,10-Dioxoanthracen-2-yl)propanal
• 英文别名: 3-(9,10-dioxoanthracen-2-yl)propanal
• CAS: 82203-76-7
• 化学式: C₁₇H₁₂O₃
• 分子量: 264.28
• InChiKey: JONRDSDCIWCHNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  51.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(9,10-Dioxoanthracen-2-yl)propanal 在 dimethyl sulfide borane 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 2-(3-hydroxypropyl)anthracene-9,10-dione
  参考文献：
  名称：

  Amide backbone modifications for antisense oligonucleotides carrying potential intercalating substituents: Influence on the thermodynamic stability of the corresponding duplexes with RNA- and DNA- complements

  摘要：

  The synthesis of the amide dimers 3-5 carrying a potential intercalating substituent on the nitrogen atom of the backbone is presented, together with the incorporation of these modifications into oligonucleotides, the resulting melting temperatures (T-m's) of the corresponding duplexes with RNA- and DNA- complements and a summary of molecular modeling studies. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00318-1
• 作为产物：
  描述：

  2-溴甲基蒽醌 在 sodium periodate 、 四氧化锇 、 偶氮二异丁腈 、 N-甲基吗啉氧化物 作用下， 以 1,4-二氧六环 为溶剂， 反应 81.0h， 生成 3-(9,10-Dioxoanthracen-2-yl)propanal
  参考文献：
  名称：

  Amide backbone modifications for antisense oligonucleotides carrying potential intercalating substituents: Influence on the thermodynamic stability of the corresponding duplexes with RNA- and DNA- complements

  摘要：

  The synthesis of the amide dimers 3-5 carrying a potential intercalating substituent on the nitrogen atom of the backbone is presented, together with the incorporation of these modifications into oligonucleotides, the resulting melting temperatures (T-m's) of the corresponding duplexes with RNA- and DNA- complements and a summary of molecular modeling studies. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00318-1

文献信息

• Further antineoplastic terpenylquinones and terpenylhydroquinones
  作者：JoséM. Miguel del Corral、Marina Gordaliza、M. Angeles Castro、M.Mar Mahiques、Arturo San Feliciano、M.Dolores García-Grávalos

  DOI：10.1016/s0968-0896(97)10007-4

  日期：1998.1

  Influences of the quinone/hydroquinone fragment and other structural features are considered in relation with the antineoplastic activity and selectivity of terpenylquinones/hydroquinones. Several compounds have shown IC50 values under the mu M level. (C) 1998 Elsevier Science Ltd. All rights reserved.