ethyl 2,2-dichloro-2-(phenylamino)acetate | 51413-36-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 2,2-dichloro-2-(phenylamino)acetate
• 英文别名: anilino-dichloro-acetic acid ethyl ester；Anilino-dichlor-essigsaeure-aethylester；Oxalsaeure-aethylester-anilidchlorid；Ethyl 2-anilino-2,2-dichloroacetate
• CAS: 51413-36-6
• 化学式: C₁₀H₁₁Cl₂NO₂
• 分子量: 248.109
• InChiKey: IRPAANXDPJRGLJ-UHFFFAOYSA-N

物化性质

• 沸点：
  327.9±42.0 °C(Predicted)
• 密度：
  1.343±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 2,2-dichloro-2-(phenylamino)acetate 生成 phenyl-oxalomonoimidic acid-2-ethyl ester-1-chloride
  参考文献：
  名称：

  Klinger, Justus Liebigs Annalen der Chemie, 1877, vol. 184, p. 263

  摘要：

  DOI：
• 作为产物：
  描述：

  草酸乙酯 在 五氯化磷 作用下， 以 甲苯 为溶剂， 反应 5.0h， 以54%的产率得到ethyl 2,2-dichloro-2-(phenylamino)acetate
  参考文献：
  名称：

  2-(芳氨基)-2-(芳亚氨基)乙酰胺的合成

  摘要：

  2-(芳基氨基)-2-氧代乙酸酯与PCl5反应得到2-(芳基氨基)-2,2-二氯乙酸酯。这些化合物与苯胺衍生物的反应允许方便地合成多种 2-(芳基氨基)-2-(芳基亚氨基)乙酰胺。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

  DOI：

  10.1002/ejoc.200300625

文献信息

• Are Persons With Cognitive Impairment Able to State Consistent Choices?
  作者：Lynn Friss Feinberg、Carol J. Whitlatch

  DOI：10.1093/geront/41.3.374

  日期：2001.6.1

  Purpose: This study examined the decision-making capacity of persons with cognitive impairment with respect to their everyday care preferences and choices. This is the first in a series of articles to report on findings from a larger study that examines choice, decision making, values, preferences, and practices in everyday care for community-dwelling persons with cognitive impairment and their family caregivers. Design and Methods: Fifty-one respondent pairs, or dyads, were interviewed, that is, persons with cognitive impairment (n = 51) and their family caregivers (n = 51). All persons with cognitive impairment were interviewed twice within a week using a parallel interview to determine stability and accuracy of responses. The family caregiver was interviewed once. Results: Persons with mild to moderate cognitive impairment (i.e., Mini-Mental State Exam scores 13–26) are able to respond consistently to questions about preferences, choices, and their own involvement in decisions about daily living, and to provide accurate and reliable responses to questions about demographics. Implications: Including the perspective of persons with cognitive impairment in both research and practice has the potential to enhance their autonomy and improve their quality of life.

  目的：本研究考察了认知障碍人士在日常生活护理偏好和选择方面的决策能力。这是系列文章中的第一篇，旨在报告一项规模更大的研究的发现，该研究调查了社区居住的认知障碍人士及其家庭护理者日常护理中的选择、决策、价值观、偏好和实践。方法与设计：本研究采访了 51 对受访者组合，即认知障碍人士（n=51）及其家庭护理者（n=51）。所有认知障碍人士在一周内进行了两次平行访谈，以确定其回答的稳定性和准确性。家庭护理者接受了一次访谈。结果：轻度至中度认知障碍人士（即 MMSE 评分为 13-26 分）能够持续回答有关偏好、选择以及他们在日常生活决策中参与程度的问题，并能准确可靠地回答有关人口统计学的问题。启示：在研究和实践中纳入认知障碍人士的观点，有可能增强其自主性并提高其生活质量。
• Living in the ‘Empire of the Gaze’: Time, Enclosure and Surveillance in a Theological College
  作者：Trevor Welland

  DOI：10.1111/1467-954x.00247

  日期：2001.2

  Interest in ‘the body’ as a focus of sociological research and theory has, in part, drawn on Foucault's concept of ‘biopower’ in order to investigate and interpret the often complex intersections of control and resistance. This type of analysis has significance for occupational socialization research that explores and interrogates the institutional settings and processes of professional preparation. In this paper, aspects of Foucault's analytic frame will be used to describe and interpret how full-time, residential training for ordained ministry functions to inscribe and regulate the ‘docile bodies’ of the trainees. It further explores the means by which students conform to and contest this ‘curriculum of the body’.

  身体 "作为社会学研究和理论的重点，在一定程度上借鉴了福柯的 "生物权力 "概念，以研究和解释控制与反抗之间往往复杂的交叉关系。这种类型的分析对职业社会化研究具有重要意义，因为职业社会化研究探索和审视了职业准备的制度环境和过程。在本文中，福柯分析框架的某些方面将被用来描述和解释全日制寄宿式按立圣职培训是如何发挥功能，刻画和规范受训者的 "驯服身体 "的。研究还将进一步探讨学生们是如何遵从并质疑这种 "身体课程 "的。
• Klinger, Chemische Berichte, 1875, vol. 8, p. 31276
  作者：Klinger

  DOI：——

  日期：——
• Klinger, Justus Liebigs Annalen der Chemie, 1877, vol. 184, p. 263
  作者：Klinger

  DOI：——

  日期：——
• Synthesis of 2-(Arylamino)-2-(arylimino)acetamides
  作者：Peter Langer、Rita Schroeder

  DOI：10.1002/ejoc.200300625

  日期：2004.3

  The reaction of 2-(arylamino)-2-oxoacetates with PCl5 afforded 2-(arylamino)-2,2-dichloroacetates. The reaction of these compounds with aniline derivatives allowed a convenient synthesis of a great variety of 2-(arylamino)-2-(arylimino)acetamides. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

  2-(芳基氨基)-2-氧代乙酸酯与PCl5反应得到2-(芳基氨基)-2,2-二氯乙酸酯。这些化合物与苯胺衍生物的反应允许方便地合成多种 2-(芳基氨基)-2-(芳基亚氨基)乙酰胺。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)