2-chloro-N-(4-ethenylphenyl)acetamide | 75912-17-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-N-(4-ethenylphenyl)acetamide
• CAS: 75912-17-3
• 化学式: C₁₀H₁₀ClNO
• 分子量: 195.648
• InChiKey: HTSXCLPMAHQDGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-cyclopropyl-5-pyridin-3-yl-2,4-dihydro-[1,2,4]triazole-3-thione 、 2-chloro-N-(4-ethenylphenyl)acetamide 在 caesium carbonate 作用下， 以 乙腈 为溶剂， 反应 16.0h， 生成 2-[(4-cyclopropyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-ethenylphenyl)acetamide
  参考文献：
  名称：

  Narrow SAR in odorant sensing Orco receptor agonists

  摘要：

  The systematic exploration of a series of triazole-based agonists of the cation channel insect odorant receptor is reported. The structure-activity relationships of independent sections of the molecules are examined. Very small changes to the compound structure were found to exert a large impact on compound activity. Optimal substitutions were combined using a 'mix-and-match' strategy to produce best-in-class compounds that are capable of potently agonizing odorant receptor activity and may form the basis for the identification of a new mode of insect behavior modification. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.04.081
• 作为产物：
  描述：

  4-乙烯苯胺 、 氯乙酰氯 在 三乙胺 作用下， 反应 2.0h， 生成 2-chloro-N-(4-ethenylphenyl)acetamide
  参考文献：
  名称：

  Narrow SAR in odorant sensing Orco receptor agonists

  摘要：

  The systematic exploration of a series of triazole-based agonists of the cation channel insect odorant receptor is reported. The structure-activity relationships of independent sections of the molecules are examined. Very small changes to the compound structure were found to exert a large impact on compound activity. Optimal substitutions were combined using a 'mix-and-match' strategy to produce best-in-class compounds that are capable of potently agonizing odorant receptor activity and may form the basis for the identification of a new mode of insect behavior modification. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.04.081

文献信息

• Kit for electrophoresis gel medium
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0340653A2

  公开（公告）日：1989-11-08

  A polyacrylamide type gel medium for electrophoresis is conveniently and safely prepared prior to use from a kit which comprises (1) a water-soluble copolymer of an acrylamide monomer and at least one comonomer copolymerizable therewith, which comonomer contains functional groups that permit crosslinking of said copolymer by a covalent but non-free radical initiated mechanism; and (2) a selected crosslinking agent in a package that separates it from the copolymer. Optionally, additional materials that may be usefully incorporated in the gel may be included in the kit, for example, a selected electrophoresis buffer and a complexing agent, such as SDS. The kit is used to prepare the gel by forming a solution of the copolymer in deionized water at the desired concentration of copolymer, adding a sufficient amount of any optional ingredients to provide the desired concentrations thereof, adding such concentration of the crosslinking agent as will provide a gelation time of between 5 minutes and 15 hours, and pouring the so prepared reaction mixture into a preselected mold or casting device or onto a support so as to form the resulting gel into the desired shape and size.

  用于电泳的聚丙烯酰胺型凝胶培养基在使用前可方便安全地从试剂盒中制备，试剂盒包括：(1) 一种丙烯酰胺单体和至少一种可与之共聚的共聚单体的水溶性共聚物，该共聚单体含有允许所述共聚物通过共价但非自由基引发机理交联的官能团；(2) 一种选定的交联剂，该交联剂与共聚物分装在一个包装中。此外，试剂盒中还可包括其他可用于凝胶的材料，例如选定的电泳缓冲液和络合剂（如 SDS）。该试剂盒用于制备凝胶，方法是在去离子水中形成所需浓度的共聚物溶液，加入足量的任选成分以提供所需浓度，加入一定浓度的交联剂以提供 5 分钟至 15 小时的凝胶化时间，然后将制备好的反应混合物倒入预先选择好的模具或浇注装置中，或倒入支撑物上，使得到的凝胶形成所需形状和大小。
• Diagnostic kit and method for rapid detection of antibodies
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0337785A1

  公开（公告）日：1989-10-18

  Diluent and wash compositions are useful in a rapid and sensitive assay for detecting antibodies, and especially retroviral antibodies, in a biological specimen. The diluent composition is buffered to a pH of 6 to 10 and includes a protein or carbohydrate, a surfactant and a negatively-charged organic compound. The wash composition is buffered to a pH of 5 to 10 and includes a surfactant. These compositions can be included in a diagnostic kit. The method of this invention includes mixing the biological specimen with the diluent composition, forming an immunological complex between ligand and antibodies in the specimen and separating complexed materials from uncomplexed materials using a filtration membrane and a washing step. An enzyme labeled anti-antibody is added to form a ligand-antibody-antibody complex followed by its detection using suitable reagents.

  稀释剂和洗涤组合物可用于快速灵敏地检测生物样本中的抗体，特别是逆转录病毒抗体。稀释剂组合物的 pH 值为 6 至 10，包括蛋白质或碳水化合物、表面活性剂和负电荷有机化合物。洗涤组合物的 pH 值为 5 至 10，包括表面活性剂。这些组合物可以包含在诊断试剂盒中。本发明的方法包括将生物标本与稀释剂组合物混合，在标本中的配体与抗体之间形成免疫复合物，并使用过滤膜和洗涤步骤将复合物与未复合物分离。加入酶标记的抗抗体以形成配体-抗体-抗体复合物，然后使用合适的试剂进行检测。
• Method for the purification of immunoreactive labeled thyroxine conjugates
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0467466A1

  公开（公告）日：1992-01-22

  A method for purifying immunoreactive labeled thyroxine conjugates using immobilied antibodies that are i) raised against an analogue of thyroxine (T4) and ii) cross-reactive with thyroxine.

  一种利用固定抗体纯化免疫反应标记甲状腺素共轭物的方法，这些抗体 i) 针对甲状腺素（T4）的类似物，ii) 与甲状腺素有交叉反应。
• Copolymers containing polyoxyalkylene side chains
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0468584A2

  公开（公告）日：1992-01-29

  Copolymers are prepared from (a) at least 0.5 mole % of monomers having reactive groups which are, directly or indirectly, capable of reaction with free amine or sulfhydryl groups of biologically active substances, (b) from 0.1 to 20 mole % of monomers having polyoxyalkylene side chains, each of which side chains has a molecular weight of at least 88, and (c) up to 99.4 mole % of oleophilic monomers which provide hydrophobicity to the copolymers. The copolymers can be supplied as latex particles in aqueous compositions.

  共聚物由以下单体制备而成：(a) 至少 0.5 摩尔%的单体具有可直接或间接与生物活性物质的游离胺或巯基反应的活性基团；(b) 0.1 至 20 摩尔%的单体具有聚氧亚烷基侧链，其中每条侧链的分子量至少为 88；(c) 高达 99.4 摩尔%的亲油单体为共聚物提供疏水性。共聚物可以作为水性组合物中的胶乳颗粒供应。
• Ligand analogs for immunoassays derived from dicarboxylic acid oxidation products
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0468591A2

  公开（公告）日：1992-01-29

  What is disclosed is a ligand analog comprising a dicarboxylic acid oxidation product of an immunologically reactive mono- or a polysaccharide having vicinal diols, to which a label or a support is appended through an amide or thioester linkage.

  所公开的是一种配体类似物，它由免疫反应性单糖或多糖的二羧酸氧化产物组成，该单糖或多糖具有邻位二醇，通过酰胺或硫酯连接，在其上附加标签或支持物。