bis[(S)-1-(ethoxycarbonyl)-1-(phenyl)methyl]fumarate | 365572-95-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: bis[(S)-1-(ethoxycarbonyl)-1-(phenyl)methyl]fumarate
• 英文别名: bis[(1S)-2-ethoxy-2-oxo-1-phenylethyl] (E)-but-2-enedioate
• CAS: 365572-95-8
• 化学式: C₂₄H₂₄O₈
• 分子量: 440.45
• InChiKey: YKKDOPZLDFCANR-FSUQMGBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  32
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  bis[(S)-1-(ethoxycarbonyl)-1-(phenyl)methyl]fumarate 在 臭氧 、 二甲基硫 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 (S)-(2-Oxo-acetoxy)-phenyl-acetic acid ethyl ester
  参考文献：
  名称：

  The aza-Diels–Alder reaction protocol—a useful approach to chiral, sterically constrained α-amino acid derivatives

  摘要：

  Different types of polycyclic alpha -amino acid derivatives are prepared from chiral imines by using well-established aza-Diels-Alder reaction conditions. Simply by varying the diene moiety, different products such as spirocyclic compounds 8 and 9, anthracene 10, and tetrahydroquinolines 15-21 are formed. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00531-2
• 作为产物：
  描述：

  反丁烯二酰氯 、 L-(+)-扁桃酸乙酯 生成 bis[(S)-1-(ethoxycarbonyl)-1-(phenyl)methyl]fumarate
  参考文献：
  名称：

  The aza-Diels–Alder reaction protocol—a useful approach to chiral, sterically constrained α-amino acid derivatives

  摘要：

  Different types of polycyclic alpha -amino acid derivatives are prepared from chiral imines by using well-established aza-Diels-Alder reaction conditions. Simply by varying the diene moiety, different products such as spirocyclic compounds 8 and 9, anthracene 10, and tetrahydroquinolines 15-21 are formed. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00531-2

文献信息

• The aza-Diels–Alder reaction protocol—a useful approach to chiral, sterically constrained α-amino acid derivatives
  作者：Sophie K Bertilsson、Jenny K Ekegren、Stefan A Modin、Pher G Andersson

  DOI：10.1016/s0040-4020(01)00531-2

  日期：2001.7

  Different types of polycyclic alpha -amino acid derivatives are prepared from chiral imines by using well-established aza-Diels-Alder reaction conditions. Simply by varying the diene moiety, different products such as spirocyclic compounds 8 and 9, anthracene 10, and tetrahydroquinolines 15-21 are formed. (C) 2001 Elsevier Science Ltd. All rights reserved.