1,3,5-tris(maleimido)benzene | 21217-67-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 1,3,5-tris(maleimido)benzene
• 英文别名: 1-[3,5-Bis(2,5-dioxopyrrol-1-yl)phenyl]pyrrole-2,5-dione
• CAS: 21217-67-4
• 化学式: C₁₈H₉N₃O₆
• 分子量: 363.286
• InChiKey: ZGCDJNIEHXPHOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  112
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  马来酸酐 生成 1,3,5-tris(maleimido)benzene
  参考文献：
  名称：

  SAITO, EIICHIRO;MATSUMURA, MASAHIRO

  摘要：

  DOI：

文献信息

• ACID-RESISTANT BASE AND/OR RADICAL GENERATOR, AND CURABLE RESIN COMPOSITION CONTAINING SAID BASE AND/OR RADICAL GENERATOR
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：US20190002403A1

  公开（公告）日：2019-01-03

  The present invention relates to a compound represented by the general formula (A), a base- and/or radical-generating agent comprising the compound, and so on. In the formula, four pieces of R 1 each independently represents a hydrogen atom or a fluorine atom; four pieces of R 2 each independently represent a fluorine atom or a trifluoromethyl group; R 3 , R 6 , R 7 and R 10 each independently represent a hydrogen atom or an alkyl group having 1 to 12 carbon atoms; R 4 and R 5 each independently represent a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, or R 4 and R 5 are bonded to each other to represent an alkylene group having 2 to 4 carbon atoms; and R 8 and R 9 each independently represent a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, or an aryl group having 6 to 14 carbon atoms and optionally having a substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, a dialkylamino group having 2 to 12 carbon atoms, a halogen atom, and a nitro group, or R 8 and R 9 are bonded to each other to represent an alkylene group having 2 to 4 carbon atoms; provided that two or three of the eight groups R 3 to R 10 are each a hydrogen atom, and, in a case where two of the eight groups are each a hydrogen atom, then three to six of the remaining groups are each an alkyl group having 1 to 12 carbon atoms, and, in a case where three of the eight groups are each a hydrogen atom, then four or five of the remaining groups are each an alkyl group having 1 to 12 carbon atoms.

  本发明涉及一种由通式（A）表示的化合物，包括该化合物的生成碱基和/或基团产生剂等。在该式中，四个R1分别独立表示氢原子或氟原子；四个R2分别独立表示氟原子或三氟甲基基团；R3、R6、R7和R10分别独立表示氢原子或具有1至12个碳原子的烷基基团；R4和R5分别独立表示氢原子或具有1至12个碳原子的烷基基团，或者R4和R5相互连接表示具有2至4个碳原子的亚烷基基团；R8和R9分别独立表示氢原子、具有1至12个碳原子的烷基基团或具有6至14个碳原子且可选地具有选自包括具有1至6个碳原子的烷基基团、具有1至6个碳原子的烷氧基团、具有1至6个碳原子的烷硫基团、具有2至12个碳原子的二烷基氨基团、卤素原子和硝基基团的取代基的芳基团，或者R8和R9相互连接表示具有2至4个碳原子的亚烷基基团；前提是八个基团R3至R10中的两个或三个分别是氢原子，并且在其中两个基团分别是氢原子的情况下，其余基团中的三到六个分别是具有1至12个碳原子的烷基基团，而在其中三个基团分别是氢原子的情况下，其余基团中的四个或五个分别是具有1至12个碳原子的烷基基团。
• Antitumor Activity of Ribonuclease Multimers Created by Site-Specific Covalent Tethering
  作者：Thomas J. Rutkoski、John A. Kink、Laura E. Strong、Christine I. Schilling、Ronald T. Raines

  DOI：10.1021/bc100292x

  日期：2010.9.15

  Site-specific cross-linking can generate homogeneous multimeric proteins of defined valency. Pancreatic-type ribonucleases are an especially attractive target, as their natural dimers can enter mammalian cells, evade the cytosolic ribonuclease inhibitor (RI), and exert their toxic ribonucleolytic activity. Here, we report on the use of eight distinct thiol-reactive cross-linking reagents to produce dimeric

  位点特异性交联可以产生具有确定价数的同质多聚体蛋白质。胰腺型核糖核酸酶是一个特别有吸引力的目标，因为它们的天然二聚体可以进入哺乳动物细胞，逃避胞质核糖核酸酶抑制剂 (RI)，并发挥其有毒的核糖核酸酶活性。在这里，我们报告了使用八种不同的硫醇反应性交联试剂来生产四种胰腺型核糖核酸酶的二聚体和三聚体偶联物。缀合位点和在较小程度上，缀合物内单体的邻近性调节对 RI 的亲和力，并因此调节细胞毒性。尽管如此，多聚体的细胞毒性在体外仍令人困惑通过它们增加的流体动力学半径，减弱细胞质进入。牛胰腺核糖核酸酶 (RNase A) 的单体 RI 逃避变体可抑制小鼠中人类前列腺和肺肿瘤的生长。与单体相比，RI 逃避三聚体缀合物以较低的剂量和较少的给药频率抑制肿瘤生长。这种效果归因于循环中三聚体的持久性增强。在分子基础上，该三聚体的有效性和耐受性是厄洛替尼的 300 倍，厄洛替尼在临床上用于治疗肺癌。这些数据鼓励
• Methods of making thin-film wiring boards, thin-film wiring boards made thereby, and adhesive materials
  申请人：HITACHI, LTD.

  公开号：EP0552984A2

  公开（公告）日：1993-07-28

  A wiring board having plural layers is made by bonding together individual wiring sheets (1,11,21), each typically comprising copper wiring on a polyimide film substrate. The sheets are bonded together by applying a liquid varnish (16,26) to the wired surface (3) of one sheet. The varnish contains a polyimide precursor, preferably a polyamic acid ester, or a soluble polyimide, as well as a thermosetting adhesion promoter, preferably maleimide-terminated. The liquid varnish (16,26) is dried to a solid polyimide layer on the wired surface. A further wiring sheet is then pressed onto the polyimide layer and the adhesion promoter is polymerised by heating to bond the layers together.

  将单个布线片（1,11,21）粘合在一起可制成具有多层的布线板，每个布线片通常包括聚酰亚胺薄膜基板上的铜线。将液态清漆（16,26）涂抹在一张布线板的布线表面（3）上，即可将布线板粘合在一起。清漆含有聚酰亚胺前体（最好是聚酰胺酸酯）或可溶性聚酰亚胺，以及热固性粘合促进剂（最好是马来酰亚胺封端）。液态清漆（16,26）经干燥后在布线表面形成固态聚酰亚胺层。然后将另一层布线片压在聚酰亚胺层上，通过加热使附着力促进剂聚合，从而将各层粘合在一起。
• POLYMERIZABLE COMPOUND AND COMPOSITION, LIQUID CRYSTAL COMPOSITE, OPTICALLY ANISOTROPIC BODY, LIQUID CRYSTAL DISPLAY ELEMENT, AND USE THEREFOR
  申请人：JNC Corporation

  公开号：EP3459934A1

  公开（公告）日：2019-03-27

  Provided are a polymerizable compound having at least one monovalent group (A), a polymerizable composition containing the polymerizable compound, a liquid crystal composite prepared from the polymerizable composition, and a liquid crystal device having the polymerizable composition. In monovalent group (A), R1 and R2 are independently hydrogen, halogen or alkyl having 1 to 20 carbons, and in the alkyl, at least one piece of -CH2- may be replaced by -O- or -S-, and at least one piece of -(CH2)2- may be replaced by -CH=CH-, and in the groups, at least one hydrogen may be replaced by halogen.

  本文提供了一种具有至少一个单价基团（A）的可聚合化合物、一种含有该可聚合化合物的可聚合组合物、一种由该可聚合组合物制备的液晶复合材料，以及一种具有该可聚合组合物的液晶装置。 在单价基团（A）中，R1 和 R2 独立地是氢、卤素或具有 1 至 20 个碳原子的烷基，在烷基中，至少一片 -CH2- 可被 -O- 或 -S- 取代，至少一片 -(CH2)2- 可被 -CH=CH- 取代，在基团中，至少一个氢可被卤素取代。
• Acid-resistant base and/or radical generator, and curable resin composition containing said base and/or radical generator
  申请人：FUJIFILM Wako Pure Chemical Corporation

  公开号：US10428015B2

  公开（公告）日：2019-10-01

  The present invention relates to a compound represented by the general formula (A), a base- and/or radical-generating agent comprising the compound, and so on. In the formula, four pieces of R1 each independently represents a hydrogen atom or a fluorine atom; four pieces of R2 each independently represent a fluorine atom or a trifluoromethyl group; R3, R6, R7 and R10 each independently represent a hydrogen atom or an alkyl group having 1 to 12 carbon atoms; R4 and R5 each independently represent a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, or R4 and R5 are bonded to each other to represent an alkylene group having 2 to 4 carbon atoms; and R8 and R9 each independently represent a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, or an aryl group having 6 to 14 carbon atoms and optionally having a substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, a dialkylamino group having 2 to 12 carbon atoms, a halogen atom, and a nitro group, or R8 and R9 are bonded to each other to represent an alkylene group having 2 to 4 carbon atoms; provided that two or three of the eight groups R3 to R10 are each a hydrogen atom, and, in a case where two of the eight groups are each a hydrogen atom, then three to six of the remaining groups are each an alkyl group having 1 to 12 carbon atoms, and, in a case where three of the eight groups are each a hydrogen atom, then four or five of the remaining groups are each an alkyl group having 1 to 12 carbon atoms.

  本发明涉及通式（A）代表的化合物、包含该化合物的碱和/或自由基生成剂等。 式中，R1 的四个部分各自独立地代表氢原子或氟原子；R2 的四个部分各自独立地代表氟原子或三氟甲基；R3、R6、R7 和 R10 各自独立地代表氢原子或具有 1 至 12 个碳原子的烷基；R4 和 R5 各自独立地代表氢原子或具有 1 至 12 个碳原子的烷基，或 R4 和 R5 相互键合代表具有 2 至 4 个碳原子的亚烷基；和 R8 和 R9 各自独立地代表一个氢原子、一个具有 1 至 12 个碳原子的烷基或一个具有 6 至 14 个碳原子的芳基，并可选择具有一个取代基，该取代基可选自具有 1 至 6 个碳原子的烷基、具有 1 至 6 个碳原子的烷氧基、具有 1 至 6 个碳原子的烷硫基、具有 2 至 12 个碳原子的二烷基氨基、卤素原子和硝基组成的组，或 R8 和 R9 相互键合代表一个具有 2 至 4 个碳原子的亚烷基；条件是八个基团 R3 至 R10 中的两个或三个基团各自为氢原子，在八个基团中的两个基团各自为氢原子的情况下，其余基团中的三至六个基团各自为具有 1 至 12 个碳原子的烷基，在八个基团中的三个基团各自为氢原子的情况下，其余基团中的四个或五个基团各自为具有 1 至 12 个碳原子的烷基。