γ-Diethylamino-butyramid | 4269-26-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: γ-Diethylamino-butyramid
• 英文别名: 4-(Diethylamino)butanamide
• CAS: 4269-26-5
• 化学式: C₈H₁₈N₂O
• 分子量: 158.244
• InChiKey: SNZVIMYBTKATPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  γ-Diethylamino-butyramid 、 乙胺 生成 N-Ethyl-γ-diethylamino-butyramid
  参考文献：
  名称：

  The IR spectra, the NIR spectra and the conformation of some basic amides

  摘要：

  DOI：

  10.1016/s0040-4020(01)93901-8
• 作为产物：
  描述：

  4-(二乙基氨基)丁酸 生成 γ-Diethylamino-butyramid
  参考文献：
  名称：

  The IR spectra, the NIR spectra and the conformation of some basic amides

  摘要：

  DOI：

  10.1016/s0040-4020(01)93901-8

文献信息

• [EN] MODIFIED CHLOROQUINES WITH BRANCHED MOIETY<br/>[FR] CHLOROQUINES MODIFIÉES À GROUPEMENTS RAMIFIÉS
  申请人：DESIGNMEDIX INC

  公开号：WO2010065925A1

  公开（公告）日：2010-06-10

  The disclosure provides modified chloroquine compounds having branched moieties. Also provided are pharmaceutical compositions comprising such compounds, methods of using such compounds to inhibit or treat diseases or conditions caused by chloroquine-resistant (CQR) and chloroquine-sensitive (CQS) malaria parasites and other CQ-susceptible microorganisms, and processes and intermediates useful for preparing such compounds

  该披露提供了具有分支基团的改良氯喹化合物。还提供了包含这种化合物的药物组合物，使用这种化合物来抑制或治疗由氯喹耐药（CQR）和氯喹敏感（CQS）疟疾寄生虫以及其他氯喹敏感微生物引起的疾病或症状的方法，以及用于制备这种化合物的工艺和中间体。
• METHOD FOR PRODUCING N-METHYL-N-VINYLACETAMIDE HAVING IMPROVED STABILITY AND POLYMERIZABILITY
  申请人：Showa Denko K.K.

  公开号：EP2239250A1

  公开（公告）日：2010-10-13

  The present invention relates to a method for producing N-methyl-N-vinylacetamide, which comprises a step for controlling the N-1,3-butadienyl-N-methylacetamide content in N-methyl-N-vinylacetamide to 0.01-150 ppm. This method enables production of N-methyl-N-vinylacetamide having a stable quality, which can be controlled in stability and polymerizability as a monomer. N-methyl-N-vinylacetamide produced by the method enables production of an N-methyl-N-vinylacetamide polymer having stable physical properties such as a molecular weight.

  本发明涉及一种生产N-甲基-N-乙烯基乙酰胺的方法，其中包括控制N-1,3-丁二烯基-N-甲基乙酰胺在N-甲基-N-乙烯基乙酰胺中的含量为0.01-150 ppm的步骤。该方法使得能够生产具有稳定质量的N-甲基-N-乙烯基乙酰胺，可以在稳定性和聚合性作为单体中进行控制。通过该方法生产的N-甲基-N-乙烯基乙酰胺能够生产具有稳定物理性质，如分子量的N-甲基-N-乙烯基乙酰胺聚合物。
• Amine derivatives for the treatment of apoptosis
  申请人：——

  公开号：US20030216427A1

  公开（公告）日：2003-11-20

  The present invention is related to substituted amine derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such amine derivatives of formula (I). Said substituted amine derivatives are efficient modulators, in particular inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel substituted amine derivatives as well as methods of their preparation.

  本发明涉及替代胺衍生物，特别是用作药用活性化合物的替代胺衍生物，以及包含该式（I）的胺衍生物的药物配方。所述替代胺衍生物是Bax功能和/或激活的高效调节剂，特别是抑制剂。本发明还涉及新型替代胺衍生物以及其制备方法。
• [EN] NOVEL THIAZOLE DERIVATES<br/>[FR] NOUVEAUX DERIVES DE THIAZOLE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005058887A1

  公开（公告）日：2005-06-30

  The present invention relates to compounds of formula (I)wherein R1, R2, R3 and R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, for use as therapeutically active substances. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB 1 receptors.

  本发明涉及式（I）的化合物，其中R1、R2、R3和R4如描述和索赔中所定义，并其药用盐，用作治疗活性物质。这些化合物可用于与CB 1受体调节相关的疾病的治疗和/或预防。
• N-(1-HYDROXYETHYL ) CARBOXAMIDE COMPOUND AND PROCESS FOR PRODUCING SAME
  申请人：Ohta Keisuke

  公开号：US20110294974A1

  公开（公告）日：2011-12-01

  The present invention relates to an N-(1-hydroxyethyl)carboxamide compound represented by formula (1) (in the formula, R A and R B represent independently from each other a hydrogen atom or an alkyl group having 1 to 4 carbon atoms except for a case where R A and R B represent a hydrogen atom at the same time) and a method for producing the same; a method for producing an N-(1-alkoxyethyl)carboxamide compound; a method for producing an N-vinyl carboxylic acid amide compound; and a method for producing an N-vinyl carboxylic acid amide (co)polymer. An N-(1-alkoxyethyl)carboxamide compound can be obtained by reacting N-(1-hydroxyethyl)carboxamide compound with alcohol in the presence of an acid catalyst, and an N-vinyl carboxylic acid amide compound, which is a monomer of the N-vinyl carboxylic acid amide (co)polymer, can be obtained by thermally decomposing or catalytically decomposing the N-(1-alkoxyethyl)carboxamide compound.

  本发明涉及一种由式（1）表示的N-（1-羟乙基）羧酰胺化合物（在该式中，RA和RB独立地表示氢原子或具有1至4个碳原子的烷基，除非RA和RB同时表示氢原子），以及其制备方法；一种制备N-（1-烷氧基乙基）羧酰胺化合物的方法；一种制备N-乙烯基羧酸酰胺化合物的方法；以及一种制备N-乙烯基羧酸酰胺（共）聚合物的方法。在酸催化剂存在下，可以通过将N-（1-羟乙基）羧酰胺化合物与醇反应来获得N-（1-烷氧基乙基）羧酰胺化合物，而将N-（1-烷氧基乙基）羧酰胺化合物热分解或催化分解可以获得N-乙烯基羧酸酰胺化合物，后者是N-乙烯基羧酸酰胺（共）聚合物的单体。