(+/-)-methyl methoxy(diethylamido)phosphorylacetate | 183426-38-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (+/-)-methyl methoxy(diethylamido)phosphorylacetate
• 英文别名: Methyl 2-(diethylamino-methoxy-oxidophosphaniumyl)acetate；methyl 2-(diethylamino-methoxy-oxidophosphaniumyl)acetate
• CAS: 183426-38-2
• 化学式: C₈H₁₈NO₄P
• 分子量: 223.209
• InChiKey: SDHUEGXFUJUZTN-UHFFFAOYSA-N

物化性质

• 沸点：
  270.4±42.0 °C(Predicted)
• 密度：
  1.105±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (二乙基氨基)二甲氧基膦 反应 1.0h， 生成 (+/-)-methyl methoxy(diethylamido)phosphorylacetate
  参考文献：
  名称：

  Enzyme-promoted kinetic resolution of racemic, P-chiral phosphonyl and phosphorylacetates

  摘要：

  A series of racemic methyl phosphonyl- and phosphorylacetates were hydrolyzed in the presence of porcine liver esterase (PLE) under kinetic resolution conditions to give the corresponding P-chiral phosphonyl- and phosphorylacetic acids and recovered esters in moderate to high enantiomeric purity (up to 95% ee). The Jones PLE active site model was applied to explain the enantioselectivity of this reaction. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00258-4

文献信息

• Enzyme-promoted kinetic resolution of racemic, P-chiral phosphonyl and phosphorylacetates
  作者：Piotr Kiełbasiński、Piotr Góralczyk、Marian Mikołajczyk、Michał W. Wieczorek、Wiesław R. Majzner

  DOI：10.1016/s0957-4166(98)00258-4

  日期：1998.8

  A series of racemic methyl phosphonyl- and phosphorylacetates were hydrolyzed in the presence of porcine liver esterase (PLE) under kinetic resolution conditions to give the corresponding P-chiral phosphonyl- and phosphorylacetic acids and recovered esters in moderate to high enantiomeric purity (up to 95% ee). The Jones PLE active site model was applied to explain the enantioselectivity of this reaction. (C) 1998 Elsevier Science Ltd. All rights reserved.